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Aliases for CLDN25 Gene

Aliases for CLDN25 Gene

  • Claudin 25 2 3 5
  • Putative Claudin-25 3

External Ids for CLDN25 Gene

Previous GeneCards Identifiers for CLDN25 Gene

  • GC11P113158
  • GC11P113650
  • GC11P109579

Summaries for CLDN25 Gene

Entrez Gene Summary for CLDN25 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. [provided by RefSeq, Jun 2010]

GeneCards Summary for CLDN25 Gene

CLDN25 (Claudin 25) is a Protein Coding gene. Among its related pathways are Tight junction and Hepatitis C. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is CLDN22.

UniProtKB/Swiss-Prot for CLDN25 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Additional gene information for CLDN25 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN25 Gene

Genomics for CLDN25 Gene

GeneHancer (GH) Regulatory Elements for CLDN25 Gene

Promoters and enhancers for CLDN25 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J113777 Enhancer 1 Ensembl ENCODE 650.7 -1.5 -1514 1.4 FOXA2 YY1 ZNF335 RCOR1 FOS THAP11 RXRA CEBPB SP1 NFIL3 CLDN25 ATF4P4 DRD2 ZW10
GH11J114031 Enhancer 0.5 FANTOM5 10.8 +251.9 251886 0.1 PKNOX1 FOXA2 HLF EZH2 FOXA1 NNMT CLDN25 USP28 GC11P114027 GC11P114056
GH11J113505 Enhancer 0.8 FANTOM5 ENCODE 5.5 -273.4 -273431 2.4 SOX5 SOX13 NFIL3 HLF CEBPA CEBPB CEBPG DRD2 CLDN25 LOC105369501 MTRF1LP1
GH11J114097 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2.3 +319.3 319264 2.7 ELF3 FOXA2 FEZF1 RAD21 RARA YY1 EGR1 ZSCAN5C THAP11 MIXL1 RBM7 ZBTB16 CLDN25 GC11M114060 LOC101928875
GH11J114152 Enhancer 2.2 UCNEbase FANTOM5 Ensembl ENCODE dbSUPER 1.2 +383.9 383876 22.1 FOXA2 SMAD1 ARNT ARID4B FEZF1 ZNF2 YY1 CBX5 ZNF213 E2F8 LRRC37A13P ENSG00000270179 ZBTB16 NXPE2P1 NNMT ATF4P4 TTC12 ZW10 CLDN25 LOC101928875
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLDN25 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CLDN25 Gene

Genomic Locations for CLDN25 Gene
754 bases
Plus strand
754 bases
Plus strand

Genomic View for CLDN25 Gene

Genes around CLDN25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN25 Gene

Proteins for CLDN25 Gene

  • Protein details for CLDN25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative claudin-25
    Protein Accession:

    Protein attributes for CLDN25 Gene

    229 amino acids
    Molecular mass:
    25394 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDN25 Gene

Post-translational modifications for CLDN25 Gene

No Post-translational modifications

Other Protein References for CLDN25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN25 Gene

Domains & Families for CLDN25 Gene

Gene Families for CLDN25 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CLDN25 Gene


Suggested Antigen Peptide Sequences for CLDN25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the claudin family.
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN25: view

Function for CLDN25 Gene

Molecular function for CLDN25 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Phenotypes From GWAS Catalog for CLDN25 Gene

Gene Ontology (GO) - Molecular Function for CLDN25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with CLDN25: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLDN25 Gene

Localization for CLDN25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN25 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLDN25 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CLDN25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CLDN25: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLDN25 Gene

Pathways & Interactions for CLDN25 Gene

genes like me logo Genes that share pathways with CLDN25: view

Pathways by source for CLDN25 Gene

Interacting Proteins for CLDN25 Gene

Gene Ontology (GO) - Biological Process for CLDN25 Gene


No data available for SIGNOR curated interactions for CLDN25 Gene

Drugs & Compounds for CLDN25 Gene

No Compound Related Data Available

Transcripts for CLDN25 Gene

mRNA/cDNA for CLDN25 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLDN25 Gene

Claudin 25:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN25 Gene

No ASD Table

Relevant External Links for CLDN25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLDN25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLDN25 Gene

mRNA differential expression in normal tissues according to GTEx for CLDN25 Gene

This gene is overexpressed in Pituitary (x22.4), Muscle - Skeletal (x8.8), Testis (x5.4), Skin - Sun Exposed (Lower leg) (x5.0), and Liver (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of CLDN25 Gene:


SOURCE GeneReport for Unigene cluster for CLDN25 Gene:

genes like me logo Genes that share expression patterns with CLDN25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDN25 Gene

Orthologs for CLDN25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLDN25 34 33
  • 99.42 (n)
(Canis familiaris)
Mammalia CLDN25 34 33
  • 86.11 (n)
(Bos Taurus)
Mammalia CLDN25 34 33
  • 85.74 (n)
(Rattus norvegicus)
Mammalia LOC100360390 33
  • 80.79 (n)
(Monodelphis domestica)
Mammalia CLDN25 34
  • 59 (a)
(Mus musculus)
Mammalia Cldn13 34
  • 27 (a)
(Gallus gallus)
Aves CLDN25 34 33
  • 59.1 (n)
(Anolis carolinensis)
Reptilia CLDN25 34
  • 43 (a)
(Danio rerio)
Actinopterygii CLDN22 34
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10090 34
  • 25 (a)
-- 34
  • 22 (a)
Species where no ortholog for CLDN25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN25 Gene

Gene Tree for CLDN25 (if available)
Gene Tree for CLDN25 (if available)
Evolutionary constrained regions (ECRs) for CLDN25: view image

Paralogs for CLDN25 Gene

Paralogs for CLDN25 Gene

(13) SIMAP similar genes for CLDN25 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLDN25: view

Variants for CLDN25 Gene

Sequence variations from dbSNP and Humsavar for CLDN25 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000552043 -- 113,778,279(+) G/A upstream_transcript_variant
rs1000587808 -- 113,778,052(+) C/G upstream_transcript_variant
rs1002060944 -- 113,778,716(+) C/T upstream_transcript_variant
rs1002495449 -- 113,778,419(+) C/T upstream_transcript_variant
rs1003089659 -- 113,779,707(+) C/T upstream_transcript_variant

Variation tolerance for CLDN25 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLDN25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CLDN25 Gene

Disorders for CLDN25 Gene

Additional Disease Information for CLDN25

No disorders were found for CLDN25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDN25 Gene

Publications for CLDN25 Gene

  1. The claudins. (PMID: 19706201) Lal-Nag M … Morin PJ (Genome biology 2009) 3 58
  2. Structure and function of claudins. (PMID: 18036336) Krause G … Blasig IE (Biochimica et biophysica acta 2008) 3 58
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  4. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PMID: 12736707) Katoh M … Katoh M (International journal of molecular medicine 2003) 3 58
  5. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 58

Products for CLDN25 Gene

Sources for CLDN25 Gene

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