This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal t... See more...

Aliases for CLDN23 Gene

Aliases for CLDN23 Gene

  • Claudin 23 2 3 5
  • Claudin-23 3 4
  • CLDNL 2 3
  • 2310014B08Rik 3
  • HCG1646163 3
  • CLDN23 5

External Ids for CLDN23 Gene

Previous GeneCards Identifiers for CLDN23 Gene

  • GC08P008531
  • GC08P008597
  • GC08P007484
  • GC08P008562

Summaries for CLDN23 Gene

Entrez Gene Summary for CLDN23 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer. [provided by RefSeq, Aug 2010]

GeneCards Summary for CLDN23 Gene

CLDN23 (Claudin 23) is a Protein Coding gene. Diseases associated with CLDN23 include Gastric Cancer. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN9.

UniProtKB/Swiss-Prot Summary for CLDN23 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLDN23 Gene

Genomics for CLDN23 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CLDN23 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J008701 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 290.6 +0.6 564 3.4 TBP MXD4 NR2C1 IRF2 CTCF ZIC2 SIN3A ZNF623 ELK1 REST CLDN23 NONHSAG049475.2 FAM86B3P FAM90A12P OR7E154P ERI1 RF00017-6830
GH08J008887 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 +188.8 188764 7.8 ZSCAN16 TBP MXD4 IKZF1 BHLHE40 NONO SIN3A REST FOXA2 VEZF1 MFHAS1 ERI1 FAM86B3P CLDN23 piR-41306-255 RF00017-6830
GH08J008712 Enhancer 0.6 Ensembl ENCODE 40.1 +11.2 11189 1.2 CEBPA CEBPB CEBPG HLF ATF3 CLDN23 FAM86B3P HSALNG0063288 NONHSAG049475.2 ERI1 RF00017-6830
GH08J008706 Enhancer 0.6 Ensembl 40.6 +5.2 5176 0.7 IRF4 EBF1 IKZF1 TCF12 ZNF217 ATF7 SPI1 TARDBP IKZF2 MTA2 CLDN23 NONHSAG049475.2 HSALNG0063288 ERI1 RF00017-6830
GH08J008707 Enhancer 0.4 Ensembl 40.6 +4.5 4464 0.4 GLIS1 KLF1 KLF10 CLDN23 NONHSAG049475.2 HSALNG0063288 ERI1 RF00017-6830
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLDN23 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLDN23

Top Transcription factor binding sites by QIAGEN in the CLDN23 gene promoter:
  • deltaCREB
  • E47
  • ER-alpha
  • GATA-1
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • RFX1
  • Roaz
  • Sp1

Genomic Locations for CLDN23 Gene

Latest Assembly
chr8:8,701,937-8,704,096
(GRCh38/hg38)
Size:
2,160 bases
Orientation:
Plus strand

Previous Assembly
chr8:8,559,447-8,561,606
(GRCh37/hg19 by Entrez Gene)
Size:
2,160 bases
Orientation:
Plus strand

chr8:8,559,448-8,561,616
(GRCh37/hg19 by Ensembl)
Size:
2,169 bases
Orientation:
Plus strand

Genomic View for CLDN23 Gene

Genes around CLDN23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN23 Gene

Proteins for CLDN23 Gene

  • Protein details for CLDN23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B33-CLD23_HUMAN
    Recommended name:
    Claudin-23
    Protein Accession:
    Q96B33
    Secondary Accessions:
    • Q08AJ3

    Protein attributes for CLDN23 Gene

    Size:
    292 amino acids
    Molecular mass:
    31915 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDN23 Gene

Post-translational modifications for CLDN23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDN23 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN23 Gene

Domains & Families for CLDN23 Gene

Gene Families for CLDN23 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for CLDN23 Gene

InterPro:
Blocks:
  • Claudin family signature
ProtoNet:

Suggested Antigen Peptide Sequences for CLDN23 Gene

GenScript: Design optimal peptide antigens:
  • Claudin-23 (CLD23_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96B33

UniProtKB/Swiss-Prot:

CLD23_HUMAN :
  • Belongs to the claudin family.
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN23: view

Function for CLDN23 Gene

Molecular function for CLDN23 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Phenotypes From GWAS Catalog for CLDN23 Gene

Gene Ontology (GO) - Molecular Function for CLDN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 32296183
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN23: view
genes like me logo Genes that share phenotypes with CLDN23: view

miRNA for CLDN23 Gene

miRTarBase miRNAs that target CLDN23

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDN23

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLDN23 Gene

Localization for CLDN23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN23 Gene

Cell junction, tight junction. Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLDN23 gene
Compartment Confidence
plasma membrane 3
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CLDN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0005923 bicellular tight junction IBA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CLDN23: view

Pathways & Interactions for CLDN23 Gene

genes like me logo Genes that share pathways with CLDN23: view

Gene Ontology (GO) - Biological Process for CLDN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA 21873635
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
GO:0070830 bicellular tight junction assembly IBA 21873635
genes like me logo Genes that share ontologies with CLDN23: view

No data available for SIGNOR curated interactions for CLDN23 Gene

Drugs & Compounds for CLDN23 Gene

(1) Drugs for CLDN23 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6876
genes like me logo Genes that share compounds with CLDN23: view

Transcripts for CLDN23 Gene

mRNA/cDNA for CLDN23 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDN23

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN23 Gene

No ASD Table

Relevant External Links for CLDN23 Gene

GeneLoc Exon Structure for
CLDN23

Expression for CLDN23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLDN23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDN23 Gene

This gene is overexpressed in Colon - Transverse (x7.1) and Stomach (x4.5).

Protein differential expression in normal tissues from HIPED for CLDN23 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLDN23 Gene



Protein tissue co-expression partners for CLDN23 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLDN23

SOURCE GeneReport for Unigene cluster for CLDN23 Gene:

Hs.183617

mRNA Expression by UniProt/SwissProt for CLDN23 Gene:

Q96B33-CLD23_HUMAN
Tissue specificity: Expressed in germinal center B-cells, placenta, stomach as well as in colon tumor.
genes like me logo Genes that share expression patterns with CLDN23: view

Primer products for research

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDN23 Gene

Orthologs for CLDN23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN23 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CLDN23 30 31
  • 98.97 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cldn23 30
  • 81.9 (n)
Cow
(Bos Taurus)
Mammalia CLDN23 30 31
  • 81.1 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cldn23 30 17 31
  • 80.59 (n)
OneToOne
Chicken
(Gallus gallus)
Aves CLDN23 30
  • 65.52 (n)
Lizard
(Anolis carolinensis)
Reptilia CLDN23 31
  • 53 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100490599 30
  • 55.11 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC567620 30
  • 52.24 (n)
CLDN23 (1 of 2) 31
  • 30 (a)
OneToMany
CLDN23 (2 of 2) 31
  • 28 (a)
OneToMany
Species where no ortholog for CLDN23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CLDN23 Gene

ENSEMBL:
Gene Tree for CLDN23 (if available)
TreeFam:
Gene Tree for CLDN23 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLDN23: view image

Paralogs for CLDN23 Gene

Variants for CLDN23 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLDN23 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs12548737 - p.Val210Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CLDN23 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CLDN23 Gene

Variant ID Type Subtype PubMed ID
esv2764098 CNV gain+loss 21179565
nsv1022670 CNV loss 25217958

Variation tolerance for CLDN23 Gene

Residual Variation Intolerance Score: 34.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.05; 90.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLDN23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLDN23

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN23 Gene

Disorders for CLDN23 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CLDN23 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CLDN23

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CLDN23: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLDN23 Gene

Publications for CLDN23 Gene

  1. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PMID: 12736707) Katoh M … Katoh M (International journal of molecular medicine 2003) 2 3 4 23
  2. MRPS18CP2 alleles and DEFA3 absence as putative chromosome 8p23.1 modifiers of hearing loss due to mtDNA mutation A1555G in the 12S rRNA gene. (PMID: 18154640) Ballana E … Estivill X (BMC medical genetics 2007) 3 41
  3. Epithelial-mesenchymal transition in gastric cancer (Review). (PMID: 16273224) Katoh M (International journal of oncology 2005) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. (PMID: 32694731) Aregger M … Moffat J (Nature metabolism 2020) 3

Products for CLDN23 Gene

Sources for CLDN23 Gene