This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal t... See more...

Aliases for CLDN20 Gene

Aliases for CLDN20 Gene

  • Claudin 20 2 3 5
  • Claudin-20 3 4
  • Testis Secretory Sperm-Binding Protein Li 229n 3

External Ids for CLDN20 Gene

Previous GeneCards Identifiers for CLDN20 Gene

  • GC06P155146
  • GC06M155480
  • GC06P155540
  • GC06P155616
  • GC06P155627
  • GC06P155677
  • GC06P153147

Summaries for CLDN20 Gene

Entrez Gene Summary for CLDN20 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. [provided by RefSeq, Jun 2010]

GeneCards Summary for CLDN20 Gene

CLDN20 (Claudin 20) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. Gene Ontology (GO) annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN14.

UniProtKB/Swiss-Prot Summary for CLDN20 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Wiki entry for CLDN20 Gene

Additional gene information for CLDN20 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLDN20 Gene

Genomics for CLDN20 Gene

GeneHancer (GH) Regulatory Elements for CLDN20 Gene

Promoters and enhancers for CLDN20 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J155261 Enhancer 1 Ensembl ENCODE dbSUPER 500.7 -1.7 -1679 3.3 ZBTB40 TEAD4 FOXA2 GATA3 YY1 MEF2B RBM22 EBF1 CTCF RAD21 CLDN20 ENSG00000235381 TIAM2 lnc-TFB1M-5 TFB1M
GH06J155264 Enhancer 0.8 Ensembl ENCODE dbSUPER 500.7 +1.0 988 0.8 FOS RCOR1 AGO2 CHD2 CLDN20 ENSG00000235381 TIAM2 piR-56759-504 TFB1M lnc-TFB1M-5
GH06J155448 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 6.4 +185.5 185488 2.6 ZSCAN5C HDAC2 RBM25 REST PBX2 ZNF335 ZMYM3 CHD4 TAF1 ETV1 CLDN20 NOX3 piR-31179-002
GH06J155417 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 1.7 +154.5 154535 2.1 EP300 ZBTB10 RELA MEF2C NFYB MYNN TCF12 CBFB POLR2A ZNF207 NOX3 CLDN20 lnc-TFB1M-3 ENSG00000232529
GH06J155267 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +9.3 9291 11 CTCF POLR2G JUND TRIM22 MXI1 ZNF316 GATA3 ZKSCAN1 FOS YY1 ENSG00000235381 TFB1M TIAM2 ENSG00000238963 HE856045 piR-56759-504 CLDN20 lnc-TFB1M-5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLDN20 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLDN20

Top Transcription factor binding sites by QIAGEN in the CLDN20 gene promoter:
  • Brachyury
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • NF-Y
  • Pbx1a
  • PPAR-gamma1
  • PPAR-gamma2
  • YY1

Genomic Locations for CLDN20 Gene

Genomic Locations for CLDN20 Gene
chr6:155,264,013-155,276,548
(GRCh38/hg38)
Size:
12,536 bases
Orientation:
Plus strand
chr6:155,585,147-155,597,682
(GRCh37/hg19)
Size:
12,536 bases
Orientation:
Plus strand

Genomic View for CLDN20 Gene

Genes around CLDN20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN20 Gene

Proteins for CLDN20 Gene

  • Protein details for CLDN20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56880-CLD20_HUMAN
    Recommended name:
    Claudin-20
    Protein Accession:
    P56880

    Protein attributes for CLDN20 Gene

    Size:
    219 amino acids
    Molecular mass:
    23515 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDN20 Gene

Post-translational modifications for CLDN20 Gene

No Post-translational modifications

Other Protein References for CLDN20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN20 Gene

Domains & Families for CLDN20 Gene

Gene Families for CLDN20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CLDN20 Gene

Blocks:
  • Claudin family signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CLDN20 Gene

GenScript: Design optimal peptide antigens:
  • Claudin-20 (CLD20_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P56880

UniProtKB/Swiss-Prot:

CLD20_HUMAN :
  • Belongs to the claudin family.
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN20: view

Function for CLDN20 Gene

Molecular function for CLDN20 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Phenotypes From GWAS Catalog for CLDN20 Gene

Gene Ontology (GO) - Molecular Function for CLDN20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN20: view

Phenotypes for CLDN20 Gene

genes like me logo Genes that share phenotypes with CLDN20: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDN20

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLDN20 Gene

Localization for CLDN20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN20 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLDN20 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CLDN20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CLDN20: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLDN20 Gene

Pathways & Interactions for CLDN20 Gene

genes like me logo Genes that share pathways with CLDN20: view

Interacting Proteins for CLDN20 Gene

;

Gene Ontology (GO) - Biological Process for CLDN20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
genes like me logo Genes that share ontologies with CLDN20: view

No data available for SIGNOR curated interactions for CLDN20 Gene

Drugs & Compounds for CLDN20 Gene

(1) Drugs for CLDN20 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884
genes like me logo Genes that share compounds with CLDN20: view

Transcripts for CLDN20 Gene

mRNA/cDNA for CLDN20 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDN20

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN20 Gene

No ASD Table

Relevant External Links for CLDN20 Gene

GeneLoc Exon Structure for
CLDN20

Expression for CLDN20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLDN20 Gene

mRNA differential expression in normal tissues according to GTEx for CLDN20 Gene

This gene is overexpressed in Nerve - Tibial (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLDN20

SOURCE GeneReport for Unigene cluster for CLDN20 Gene:

Hs.567491

Evidence on tissue expression from TISSUES for CLDN20 Gene

  • Skin(4)
genes like me logo Genes that share expression patterns with CLDN20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDN20 Gene

Orthologs for CLDN20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLDN20 31 30
  • 99.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CLDN20 31 30
  • 88.74 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CLDN20 31 30
  • 81.58 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cldn20 30
  • 80.52 (n)
mouse
(Mus musculus)
Mammalia Cldn20 17 31 30
  • 79.91 (n)
oppossum
(Monodelphis domestica)
Mammalia CLDN20 31
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLDN20 31 30
  • 73.06 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLDN20 31
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101886267 30
  • 59.67 (n)
CU695076.1 31
  • 55 (a)
OneToMany
CLDN20 (1 of 2) 31
  • 49 (a)
OneToMany
Species where no ortholog for CLDN20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN20 Gene

ENSEMBL:
Gene Tree for CLDN20 (if available)
TreeFam:
Gene Tree for CLDN20 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLDN20: view image

Paralogs for CLDN20 Gene

(17) SIMAP similar genes for CLDN20 Gene using alignment to 1 proteins:

  • CLD20_HUMAN
genes like me logo Genes that share paralogs with CLDN20: view

Variants for CLDN20 Gene

Additional dbSNP identifiers (rs#s) for CLDN20 Gene

Structural Variations from Database of Genomic Variants (DGV) for CLDN20 Gene

Variant ID Type Subtype PubMed ID
esv3611344 CNV loss 21293372
nsv1025003 CNV gain 25217958

Variation tolerance for CLDN20 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLDN20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLDN20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLDN20 Gene

Disorders for CLDN20 Gene

Additional Disease Information for CLDN20

No disorders were found for CLDN20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDN20 Gene

Publications for CLDN20 Gene

  1. Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier. (PMID: 17679949) Rizzolo LJ … Zhang H (Molecular vision 2007) 3 23 54
  2. The claudin gene family: expression in normal and neoplastic tissues. (PMID: 16836752) Hewitt KJ … Morin PJ (BMC cancer 2006) 2 3 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 54
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54

Products for CLDN20 Gene

Sources for CLDN20 Gene