External Ids for CLDN2 Gene
Previous GeneCards Identifiers for CLDN2 Gene
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010]
GeneCards Summary for CLDN2 Gene
CLDN2 (Claudin 2) is a Protein Coding gene. Diseases associated with CLDN2 include Osmotic Diarrhea and Inflammatory Bowel Disease. Among its related pathways are Cytoskeletal Signaling and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. Gene Ontology (GO) annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN14.
UniProtKB/Swiss-Prot for CLDN2 Gene
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.