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CLDN17 Gene(Protein Coding)

Claudin 17

GCID:
GC21M030165
GIFtS:
38
Genes Participants
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Aliases for CLDN17 Gene

Aliases for CLDN17 Gene

  • Claudin 17 2 3 5
  • Human CLDN17 Gene For Claudin-17 3
  • Claudin-17 3

External Ids for CLDN17 Gene

Previous GeneCards Identifiers for CLDN17 Gene

  • GC21M028115
  • GC21M030458
  • GC21M030460
  • GC21M031537
  • GC21M016947

Summaries for CLDN17 Gene

Entrez Gene Summary for CLDN17 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11. [provided by RefSeq, Jun 2010]

GeneCards Summary for CLDN17 Gene

CLDN17 (Claudin 17) is a Protein Coding gene. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Blood-Brain Barrier Pathway: Anatomy. Gene Ontology (GO) annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN8.

UniProtKB/Swiss-Prot for CLDN17 Gene

  • Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability.

Gene Wiki entry for CLDN17 Gene

Additional gene information for CLDN17 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN17 Gene

Genomics for CLDN17 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CLDN17 Gene

Promoters and enhancers for CLDN17 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH21I030166 Promoter 0.5 EPDnew 550.8 +0.0 3 0.1 CLDN17 ENSG00000259981
GH21I030233 Enhancer 0.3 ENCODE 10.7 -67.7 -67657 2.4 CEBPG LINC00307 KRTAP24-1 KRTAP25-1 CLDN17 CLDN8 GC21M030264
GH21I030146 Enhancer 0.5 ENCODE 0.4 +19.6 19599 1.8 GATA3 ZBTB21 CEBPB ID3 PRDM10 CEBPG CLDN17 ENSG00000259981
GH21I030153 Enhancer 0.4 ENCODE 0.4 +12.7 12744 1.4 ATF4 DACH1 CLDN17 ENSG00000259981
GH21I030206 Enhancer 0.5 ENCODE 0.3 -40.2 -40151 0.8 ZNF316 BACH1 MAFG NFE2 MAFK EMSY NFE2L2 LINC00307 CLDN17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CLDN17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLDN17 gene promoter:

Genomic Locations for CLDN17 Gene

Genomic Locations for CLDN17 Gene
chr21:30,165,564-30,166,756
(GRCh38/hg38)
Size:
1,193 bases
Orientation:
Minus strand
chr21:31,538,241-31,538,971
(GRCh37/hg19)

Genomic View for CLDN17 Gene

Genes around CLDN17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN17 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CLDN17 Gene

Proteins for CLDN17 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CLDN17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56750-CLD17_HUMAN
    Recommended name:
    Claudin-17
    Protein Accession:
    P56750
    Secondary Accessions:
    • Q3MJB5
    • Q6UY37

    Protein attributes for CLDN17 Gene

    Size:
    224 amino acids
    Molecular mass:
    24603 Da
    Quaternary structure:
    • Interacts with OCLN (PubMed:20375010).
    SequenceCaution:
    • Sequence=AAQ88461.1; Type=Frameshift; Positions=31; Evidence={ECO:0000305};

neXtProt entry for CLDN17 Gene

Post-translational modifications for CLDN17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDN17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN17 Gene

Domains & Families for CLDN17 Gene

Gene Families for CLDN17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for CLDN17 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CLDN17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56750

UniProtKB/Swiss-Prot:

CLD17_HUMAN :
  • Belongs to the claudin family.
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN17: view

Function for CLDN17 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CLDN17 Gene

GENATLAS Biochemistry:
claudin 17,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major structural components of tight junction (TJ) strands
UniProtKB/Swiss-Prot Function:
Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability.

Phenotypes From GWAS Catalog for CLDN17 Gene

Gene Ontology (GO) - Molecular Function for CLDN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005254 chloride channel activity IEA --
GO:0005515 protein binding IPI 20375010
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN17: view

Phenotypes for CLDN17 Gene

GenomeRNAi human phenotypes for CLDN17:
genes like me logo Genes that share phenotypes with CLDN17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLDN17 Gene

Localization for CLDN17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN17 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLDN17 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CLDN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,IEA 20375010
GO:0005923 bicellular tight junction ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CLDN17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLDN17 Gene

Pathways & Interactions for CLDN17 Gene

genes like me logo Genes that share pathways with CLDN17: view

Gene Ontology (GO) - Biological Process for CLDN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006821 chloride transport IEA --
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
GO:1902476 chloride transmembrane transport IEA --
genes like me logo Genes that share ontologies with CLDN17: view

No data available for SIGNOR curated interactions for CLDN17 Gene

Drugs & Compounds for CLDN17 Gene

Products:

  1. Drug

(1) Drugs for CLDN17 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with CLDN17: view

Transcripts for CLDN17 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CLDN17 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN17 Gene

No ASD Table

Relevant External Links for CLDN17 Gene

GeneLoc Exon Structure for
CLDN17
ECgene alternative splicing isoforms for
CLDN17

Expression for CLDN17 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLDN17 Gene

mRNA expression in normal human tissues for CLDN17 Gene
mRNA expression by GTEx for CLDN17 GenemRNA expression by BioGPS for CLDN17 Gene

mRNA differential expression in normal tissues according to GTEx for CLDN17 Gene

This gene is overexpressed in Vagina (x22.0), Esophagus - Mucosa (x16.5), Cervix - Ectocervix (x7.6), and Minor Salivary Gland (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of CLDN17 Gene:

CLDN17

SOURCE GeneReport for Unigene cluster for CLDN17 Gene:

Hs.258589

mRNA Expression by UniProt/SwissProt for CLDN17 Gene:

P56750-CLD17_HUMAN
Tissue specificity: In the kidney, expressed in the proximal tubule and in the Henles loop. In the distal convoluted tubule, not expressed in all tubules. Not detected in the collecting duct (at protein level).

Evidence on tissue expression from TISSUES for CLDN17 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with CLDN17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDN17 Gene

Orthologs for CLDN17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CLDN17 33 34
  • 99.11 (n)
dog
(Canis familiaris)
 Mammalia CLDN17 33 34
  • 89.88 (n)
cow
(Bos Taurus)
 Mammalia CLDN17 33 34
  • 82.14 (n)
mouse
(Mus musculus)
 Mammalia Cldn17 33 16 34
  • 81.4 (n)
rat
(Rattus norvegicus)
 Mammalia Cldn17 33
  • 80.21 (n)
oppossum
(Monodelphis domestica)
 Mammalia CLDN17 34
  • 75 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CLDN17 33
  • 58.41 (n)
lizard
(Anolis carolinensis)
 Reptilia CLDN17 34
  • 55 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii LOC570842 33
  • 55.79 (n)
CLDN17 34
  • 27 (a)
 OneToMany
Species where no ortholog for CLDN17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN17 Gene

ENSEMBL:
Gene Tree for CLDN17 (if available)
TreeFam:
Gene Tree for CLDN17 (if available)

Paralogs for CLDN17 Gene

Paralogs for CLDN17 Gene

(18) SIMAP similar genes for CLDN17 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLDN17: view

Variants for CLDN17 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CLDN17 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1002013415 -- 30,167,772(-) G/A/T upstream_transcript_variant
rs1002913450 -- 30,167,564(-) G/A upstream_transcript_variant
rs1005188810 -- 30,168,387(-) A/G upstream_transcript_variant
rs1005273075 -- 30,166,205(-) C/T coding_sequence_variant, missense_variant
rs1005877539 -- 30,167,200(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CLDN17 Gene

Variant ID Type Subtype PubMed ID
nsv459235 CNV gain 19166990
nsv587353 CNV gain 21841781
nsv587354 CNV gain 21841781

Variation tolerance for CLDN17 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.21; 80.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLDN17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLDN17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN17 Gene

Disorders for CLDN17 Gene

Additional Disease Information for CLDN17

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CLDN17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDN17 Gene

Publications for CLDN17 Gene

  1. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PMID: 12736707) Katoh M … Katoh M (International journal of molecular medicine 2003) 2 3 22 58
  2. Molecular basis of claudin-17 anion selectivity. (PMID: 26194246) Conrad MP … Krug SM (Cellular and molecular life sciences : CMLS 2016) 3 4 58
  3. Claudin association with CD81 defines hepatitis C virus entry. (PMID: 20375010) Harris HJ … McKeating JA (The Journal of biological chemistry 2010) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

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