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This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11. [provided by RefSeq, Jun 2010]
CLDN17 (Claudin 17) is a Protein Coding gene. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Pathogenic Escherichia coli infection. Gene Ontology (GO) annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN8.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH21J030233 | Enhancer | 0.7 | Ensembl ENCODE CraniofacialAtlas | 10.7 | -67.7 | -67709 | 2.6 | CEBPG CEBPB SMARCA4 | LINC00307 KRTAP24-1 KRTAP25-1 CLDN17 CLDN8 RPL8P2 lnc-KRTAP24-1-1 | |
GH21J030014 | Enhancer | 0.2 | Ensembl | 10.7 | +151.7 | 151704 | 0.6 | HSALNG0132571 CLDN17 lnc-GRIK1-2 GRIK1 | ||
GH21J030146 | Enhancer | 0.5 | ENCODE | 0.4 | +19.6 | 19648 | 1.8 | PRDM10 FOXA1 CEBPB GATA3 CEBPG ID3 ZBTB21 | piR-49097-062 CLDN17 GRIK1 | |
GH21J030206 | Enhancer | 0.7 | Ensembl ENCODE | 0.3 | -40.3 | -40336 | 1.3 | NFE2 ZNF316 MAFF MAFK MAFG NFE2L2 BACH1 EMSY | LINC00307 CLDN8 piR-37895-093 CLDN17 | |
GH21J030153 | Enhancer | 0.3 | ENCODE | 0.4 | +12.8 | 12793 | 1.4 | ATF4 DACH1 | piR-49097-062 CLDN17 GRIK1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005198 | structural molecule activity | IEA | -- |
GO:0005254 | chloride channel activity | IEA | -- |
GO:0005515 | protein binding | IPI | 20375010 |
GO:0042802 | identical protein binding | ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA,IDA | 20375010 |
GO:0005923 | bicellular tight junction | ISS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0030054 | cell junction | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling | ||
2 | Cell junction organization | ||
3 | Blood-Brain Barrier: Anatomy | ||
4 | Sertoli-Sertoli Cell Junction Dynamics |
Sertoli-Sertoli Cell Junction Dynamics
.38
|
Epithelial Tight Junctions
.36
|
5 | Cell adhesion molecules (CAMs) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | IEA | -- |
GO:0006821 | chloride transport | IEA | -- |
GO:0007155 | cell adhesion | IBA | 21873635 |
GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules | ISS | -- |
GO:0070830 | bicellular tight junction assembly | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Calcium | Nutra | 6556 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CLDN17 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CLDN17 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CLDN17 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cldn17 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cldn17 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CLDN17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CLDN17 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | CLDN17 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | LOC570842 30 |
|
||
CLDN17 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs35531957 | - | p.Ala82Thr |
No disorders were found for CLDN17 Gene.