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This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal t... See more...
Aliases for CLDN12 Gene
External Ids for CLDN12 Gene
- HGNC: 2034
- Entrez Gene: 9069
- Ensembl: ENSG00000157224
- OMIM: 611232
- UniProtKB: P56749
Previous GeneCards Identifiers for CLDN12 Gene
- GC07P088568
- GC07P089630
- GC07P089644
- GC07P089677
- GC07P089871
- GC07P090013
- GC07P084642
Summaries for CLDN12 Gene
-
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011]
GeneCards Summary for CLDN12 Gene
CLDN12 (Claudin 12) is a Protein Coding gene. Diseases associated with CLDN12 include Deafness, Autosomal Recessive 29. Among its related pathways are Cell junction organization and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and structural molecule activity.
UniProtKB/Swiss-Prot Summary for CLDN12 Gene
-
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Additional gene information for CLDN12 Gene
- HGNC(2034)
- Entrez Gene(9069)
- Ensembl(ENSG00000157224)
- OMIM(611232)
- UniProtKB(P56749)
- Open Targets Platform(ENSG00000157224)
- Search for CLDN12 at DataMed
- Search for CLDN12 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLDN12 Gene
Genomics for CLDN12 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CLDN12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CLDN12 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLDN12
- Top Transcription factor binding sites by QIAGEN in the CLDN12 gene promoter:
-
- AML1a
- AP-1
- c-Myc
- C/EBPbeta
- E47
- ER-alpha
- GATA-1
- Max
- STAT5B
- ZIC2
Genomic Locations for CLDN12 Gene
Genomic Locations for CLDN12 Gene
- chr7:90,383,721-90,513,402
- (GRCh38/hg38)
- Size:
- 129,682 bases
- Orientation:
- Plus strand
- chr7:90,013,035-90,142,716
- (GRCh37/hg19)
- Size:
- 129,682 bases
- Orientation:
- Plus strand
Genomic View for CLDN12 Gene
Genes around CLDN12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q21.13 by HGNC
- 7q21.13 by Entrez Gene
- 7q21.13 by Ensembl
CLDN12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CLDN12 Gene
Proteins for CLDN12 Gene
-
Protein details for CLDN12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P56749-CLD12_HUMAN
- Recommended name:
- Claudin-12
- Protein Accession:
- P56749
- D6W5Q4
- Q7LDZ0
Protein attributes for CLDN12 Gene
- Size:
- 244 amino acids
- Molecular mass:
- 27110 Da
- Quaternary structure:
-
- Interacts with OCLN (PubMed:20375010).
Protein Expression for CLDN12 Gene
Post-translational modifications for CLDN12 Gene
Other Protein References for CLDN12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CLDN12 Antibody
- HUABIO Anti-Claudin 12 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CLDN12
- Novus Biologicals Antibodies for CLDN12
-
Abcam antibodies for CLDN12
- Invitrogen Antibodies for CLDN12 (AFLGC-CLDN12)
-
Biorbyt antibodies for CLDN12
-
Boster Bio Antibodies for CLDN12
- Sino Biological Antibodies for CLDN12
Protein Products
-
OriGene Purified Proteins for CLDN12
- Search Origene for MassSpec and Protein Over-expression Lysates for CLDN12
- Origene Custom Protein Services for CLDN12
- Novus Biologicals proteins for CLDN12
-
Abcam proteins for CLDN12
No data available for DME Specific Peptides for CLDN12 Gene
Domains & Families for CLDN12 Gene
Gene Families for CLDN12 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for CLDN12 Gene
- InterPro:
- Blocks:
-
- Claudin family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for CLDN12 Gene
- GenScript: Design optimal peptide antigens:
-
- Claudin-12 (CLD12_HUMAN)
- CLDN12 protein (Q6FIF6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P56749- Family:
-
- Belongs to the claudin family.
Function for CLDN12 Gene
Molecular function for CLDN12 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
- GENATLAS Biochemistry:
- claudin 12,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major structural components of tight junction (TJ) strands
Phenotypes From GWAS Catalog for CLDN12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 20375010 |
| GO:0042802 | identical protein binding | ISS | -- |
Phenotypes for CLDN12 Gene
- MGI mutant phenotypes for CLDN12:
-
inferred from 2 alleles
- nervous system phenotype
- immune system phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- hematopoietic system phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for CLDN12:
Animal Models for CLDN12 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CLDN12 - Select products 50% OFF >
- * CLDN12 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CLDN12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLDN12
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLDN12
miRNA for CLDN12 Gene
- miRTarBase miRNAs that target CLDN12
-
- mmu-miR-362-5p (MIRT009029)
- mmu-let-7b-5p (MIRT012216)
- hsa-miR-125a-5p (MIRT021304)
- hsa-miR-30b-5p (MIRT023422)
- hsa-miR-1-3p (MIRT023604)
- hsa-miR-320b (MIRT036225)
- hsa-miR-320a (MIRT044709)
- hsa-miR-345-3p (MIRT104283)
- hsa-miR-670-5p (MIRT104284)
- hsa-miR-3140-5p (MIRT104285)
- hsa-miR-4263 (MIRT104287)
- hsa-miR-3667-5p (MIRT104288)
- hsa-miR-4680-3p (MIRT104291)
- hsa-miR-4744 (MIRT104292)
- hsa-miR-559 (MIRT104325)
- hsa-miR-548b-5p (MIRT104327)
- hsa-miR-548a-5p (MIRT104328)
- hsa-miR-548c-5p (MIRT104329)
- hsa-miR-548d-5p (MIRT104330)
- hsa-miR-548j-5p (MIRT104331)
- hsa-miR-548h-5p (MIRT104332)
- hsa-miR-548i (MIRT104333)
- hsa-miR-548w (MIRT104334)
- hsa-miR-548y (MIRT104336)
- hsa-miR-548o-5p (MIRT104337)
- hsa-miR-548ab (MIRT104338)
- hsa-miR-548ad-5p (MIRT104339)
- hsa-miR-548ae-5p (MIRT104340)
- hsa-miR-548ak (MIRT104342)
- hsa-miR-548am-5p (MIRT104343)
- hsa-miR-548ap-5p (MIRT104345)
- hsa-miR-548aq-5p (MIRT104347)
- hsa-miR-548ar-5p (MIRT104348)
- hsa-miR-548as-5p (MIRT104349)
- hsa-miR-548au-5p (MIRT104350)
- hsa-miR-548ay-5p (MIRT104351)
- hsa-miR-548bb-5p (MIRT104354)
- hsa-miR-142-3p (MIRT239936)
- hsa-let-7a-5p (MIRT260703)
- hsa-let-7b-5p (MIRT260704)
- hsa-let-7c-5p (MIRT260705)
- hsa-let-7d-5p (MIRT260706)
- hsa-let-7e-5p (MIRT260707)
- hsa-let-7f-5p (MIRT260708)
- hsa-miR-98-5p (MIRT260709)
- hsa-miR-224-5p (MIRT260710)
- hsa-let-7g-5p (MIRT260711)
- hsa-let-7i-5p (MIRT260712)
- hsa-miR-3927-3p (MIRT260713)
- hsa-miR-4458 (MIRT260714)
- hsa-miR-4500 (MIRT260715)
- hsa-miR-4650-3p (MIRT260716)
- hsa-miR-6831-5p (MIRT260717)
- hsa-miR-4760-3p (MIRT321386)
- hsa-miR-5197-3p (MIRT362931)
- hsa-miR-3622b-5p (MIRT502765)
- hsa-miR-202-3p (MIRT502766)
- hsa-miR-5693 (MIRT502767)
- hsa-miR-4719 (MIRT502768)
- hsa-miR-7856-5p (MIRT538509)
- hsa-miR-4477b (MIRT538510)
- hsa-miR-576-5p (MIRT568038)
- hsa-miR-4732-3p (MIRT568039)
- hsa-miR-6866-3p (MIRT568040)
- hsa-miR-188-5p (MIRT568041)
- hsa-miR-7161-5p (MIRT568042)
- hsa-miR-548u (MIRT568043)
- hsa-miR-4319 (MIRT568044)
- hsa-miR-125b-5p (MIRT568045)
- hsa-miR-676-5p (MIRT568046)
- hsa-miR-1294 (MIRT762335)
- hsa-miR-187-5p (MIRT763212)
- hsa-miR-206 (MIRT763732)
- hsa-miR-2467-5p (MIRT764156)
- hsa-miR-302b-5p (MIRT764471)
- hsa-miR-302d-5p (MIRT764503)
- hsa-miR-3120-3p (MIRT764777)
- hsa-miR-3188 (MIRT765336)
- hsa-miR-329-5p (MIRT765628)
- hsa-miR-3653-3p (MIRT766328)
- hsa-miR-3658 (MIRT766428)
- hsa-miR-377-5p (MIRT767373)
- hsa-miR-3975 (MIRT767903)
- hsa-miR-4316 (MIRT768582)
- hsa-miR-4457 (MIRT769206)
- hsa-miR-4461 (MIRT769397)
- hsa-miR-4703-3p (MIRT771345)
- hsa-miR-485-5p (MIRT772600)
- hsa-miR-507 (MIRT773114)
- hsa-miR-545-3p (MIRT774020)
- hsa-miR-557 (MIRT774695)
- hsa-miR-5585-5p (MIRT774743)
- hsa-miR-6086 (MIRT775504)
- hsa-miR-613 (MIRT775981)
- hsa-miR-655-5p (MIRT777301)
- hsa-miR-6716-5p (MIRT777703)
- hsa-miR-6783-5p (MIRT779078)
- hsa-miR-6884-5p (MIRT780988)
- hsa-miR-8066 (MIRT782358)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLDN12
- Browse OriGene Inhibitory RNA Products For CLDN12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDN12
Clone Products
- Applied Biological Materials (abm): Clones for CLDN12 - Select products 50% OFF >
- * CLDN12 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203047
- MG225264
- MG225326
- MG225328
- MR203047
- MR203047L3
- MR203047L4
- MR225264
- MR225264L3
- MR225264L4
- MR225326
- MR225326L1
- MR225326L2
- MR225326L3
- MR225326L4
- MR225328
- MR225328L3
- MR225328L4
- RC209820
- RC209820L1
- RC209820L2
- RC209820L3
- RC209820L4
- RC232263
- RC232264
- RG209820
- RG232263
- RG232264
- RR209298
- RR209298L3
- RR209298L4
- MR203047L3V
- MR203047L4V
- MR225264L3V
- MR225264L4V
- MR225326L1V
- MR225326L2V
- MR225326L3V
- MR225326L4V
- MR225328L3V
- MR225328L4V
- RC209820L1V
- RC209820L2V
- RC209820L3V
- RC209820L4V
- RR209298L3V
- RR209298L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CLDN12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLDN12
Cell Line Products
-
Horizon Cell Lines for CLDN12
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLDN12 Gene
Localization for CLDN12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CLDN12 Gene
- Cell junction, tight junction. Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA,IDA | 20375010 |
| GO:0005923 | bicellular tight junction | ISS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0016328 | lateral plasma membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLDN12 Gene
Pathways & Interactions for CLDN12 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling | ||
| 2 | Cell junction organization | ||
| 3 | Blood-Brain Barrier: Anatomy | ||
| 4 | Sertoli-Sertoli Cell Junction Dynamics |
Sertoli-Sertoli Cell Junction Dynamics
.38
|
Epithelial Tight Junctions
.36
|
| 5 | Integrin Pathway |
Transendothelial Migration of Leukocytes
.38
|
|
Pathways by source for CLDN12 Gene
4 Reactome pathways for CLDN12 Gene
6 R&D Systems pathways for CLDN12 Gene
- Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling
- Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling
- Blood-Brain Barrier and Immune Cell Transmigration: Overview
- Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling
- Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling
3 Qiagen pathways for CLDN12 Gene
- Epithelial Tight Junctions
- Sertoli-Sertoli Cell Junction Dynamics
- Transendothelial Migration of Leukocytes
Interacting Proteins for CLDN12 Gene
Selected Interacting proteins:
P56749-CLD12_HUMAN
ENSP00000287916
for CLDN12 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CLDN12
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules | ISS | -- |
| GO:0035633 | maintenance of permeability of blood-brain barrier | NAS | 30280653 |
| GO:0120192 | NOT tight junction assembly | ISS | -- |
No data available for SIGNOR curated interactions for CLDN12 Gene
Drugs & Compounds for CLDN12 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Calcium | Nutra | 6556 |
Transcripts for CLDN12 Gene
mRNA/cDNA for CLDN12 Gene
- 3 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000416322 1163 nts (view in UCSC)
- ENST00000287916 3565 nts (view in UCSC)
- ENST00000462636 724 nts (view in UCSC)
- ENST00000495768 674 nts (view in UCSC)
- ENST00000394604 846 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CLDN12 - Select products 50% OFF >
- * CLDN12 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CLDN12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLDN12
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLDN12
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLDN12
- Browse OriGene Inhibitory RNA Products For CLDN12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDN12
Clone Products
- Applied Biological Materials (abm): Clones for CLDN12 - Select products 50% OFF >
- * CLDN12 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203047
- MG225264
- MG225326
- MG225328
- MR203047
- MR203047L3
- MR203047L4
- MR225264
- MR225264L3
- MR225264L4
- MR225326
- MR225326L1
- MR225326L2
- MR225326L3
- MR225326L4
- MR225328
- MR225328L3
- MR225328L4
- RC209820
- RC209820L1
- RC209820L2
- RC209820L3
- RC209820L4
- RC232263
- RC232264
- RG209820
- RG232263
- RG232264
- RR209298
- RR209298L3
- RR209298L4
- MR203047L3V
- MR203047L4V
- MR225264L3V
- MR225264L4V
- MR225326L1V
- MR225326L2V
- MR225326L3V
- MR225326L4V
- MR225328L3V
- MR225328L4V
- RC209820L1V
- RC209820L2V
- RC209820L3V
- RC209820L4V
- RR209298L3V
- RR209298L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CLDN12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLDN12
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||||
| SP8: | - | - | - |
Relevant External Links for CLDN12 Gene
- GeneLoc Exon Structure for
- CLDN12
Expression for CLDN12 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Testis (Reproductive System)
This gene is overexpressed in Frontal cortex (39.0) and Retina (24.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CLDN12 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLDN12
SOURCE GeneReport for Unigene cluster for CLDN12 Gene:
Hs.731917Evidence on tissue expression from TISSUES for CLDN12 Gene
- Nervous system(4.9)
- Intestine(3.3)
- Lung(2.9)
- Blood(2.6)
- Heart(2.6)
- Kidney(2.5)
- Liver(2.4)
Primer Products
-
OriGene qPCR primer pairs for CLDN12
-
OriGene qPCR primer pairs and template standards for CLDN12
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDN12 Gene
Orthologs for CLDN12 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CLDN12 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CLDN12 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CLDN12 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CLDN12 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cldn12 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cldn12 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CLDN12 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CLDN12 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cldn12 30 |
|
||
| Str.7430 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | cldn12 30 31 |
|
OneToOne |
- Species where no ortholog for CLDN12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CLDN12 Gene
- ENSEMBL:
- Gene Tree for CLDN12 (if available)
- TreeFam:
- Gene Tree for CLDN12 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CLDN12: view image
Paralogs for CLDN12 Gene
No data available for Paralogs for CLDN12 Gene
Variants for CLDN12 Gene
Residual Variation Intolerance Score:
27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.46;
10.07% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CLDN12 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CLDN12
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLDN12 Gene
Disorders for CLDN12 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| deafness, autosomal recessive 29 |
|
|
Search CLDN12 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CLDN12
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CLDN12 Gene
Publications for CLDN12 Gene
- Claudin association with CD81 defines hepatitis C virus entry. (PMID: 20375010) Harris HJ … McKeating JA (The Journal of biological chemistry 2010) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4
ExternalLinks
Products for CLDN12 Gene
- Custom Antibody ServicesOriGene Antibodies for CLDN12
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CLDN12
- Search Origene for MassSpec and Protein Over-expression Lysates for CLDN12
- Origene Custom Protein Services for CLDN12
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLDN12
- Browse OriGene Inhibitory RNA Products For CLDN12
- OriGene qPCR primer pairs for CLDN12
- OriGene qPCR primer pairs and template standards for CLDN12
- OriGene CRISPR knockouts for CLDN12
- MG203047
- MG225264
- MG225326
- MG225328
- MR203047
- MR203047L3
- MR203047L4
- MR225264
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- MR225326
- MR225326L1
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- MR225326L3
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- MR225328
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- RC209820
- RC209820L1
- RC209820L2
- RC209820L3
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- RC232263
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- RG209820
- RG232263
- RG232264
- RR209298
- RR209298L3
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- MR203047L3V
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- MR225326L1V
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- RC209820L1V
- RC209820L2V
- RC209820L3V
- RC209820L4V
- RR209298L3V
- RR209298L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CLDN12
- Sino Biological Human cDNA Clone for CLDN12
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for CLDN12
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CLDN12
- Novus Biologicals proteins for CLDN12
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
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- Abcam antibodies for CLDN12
- Abcam proteins for CLDN12
- Find your target
- Browse Primary Antibodies
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- Invitrogen Antibodies for CLDN12 (AFLGC-CLDN12)
- VectorBuilder Custom and pre-made DNA vectors for CLDN12 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CLDN12 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CLDN12 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CLDN12 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CLDN12
- antibodies-online: Show 25 available CLDN12 Antibodies ranked by validation data
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- antibodies-online: Show 12 available CLDN12 Elisa Kits ranked by validation data
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- antibodies-online: Show 3 available CLDN12 Proteins ranked by validation data
- Compare Top CLDN12 Proteins
- Horizon Cell Lines for CLDN12
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLDN12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLDN12
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CLDN12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDN12
- Boster Bio Antibodies for CLDN12
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for CLDN12
Sources for CLDN12 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB