Aliases for CLCF1 Gene
External Ids for CLCF1 Gene
Previous GeneCards Identifiers for CLCF1 Gene
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
GeneCards Summary for CLCF1 Gene
CLCF1 (Cardiotrophin Like Cytokine Factor 1) is a Protein Coding gene. Diseases associated with CLCF1 include Crisponi/Cold-Induced Sweating Syndrome 2 and Cold-Induced Sweating Syndrome. Among its related pathways are Interleukin-6 family signaling and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and cytokine activity.
UniProtKB/Swiss-Prot for CLCF1 Gene
Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.