Aliases for CLCF1 Gene
External Ids for CLCF1 Gene
Previous GeneCards Identifiers for CLCF1 Gene
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
GeneCards Summary for CLCF1 Gene
CLCF1 (Cardiotrophin Like Cytokine Factor 1) is a Protein Coding gene. Diseases associated with CLCF1 include Crisponi/Cold-Induced Sweating Syndrome 2 and Cold-Induced Sweating Syndrome. Among its related pathways are PEDF Induced Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and cytokine activity. An important paralog of this gene is CTF1.
UniProtKB/Swiss-Prot Summary for CLCF1 Gene
In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor.