CLCA4 Gene (Protein Coding)

Chloride Channel Accessory 4

GC01P086547
GIFtS:
38
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript varian... See more...

Aliases for CLCA4 Gene

Aliases for CLCA4 Gene

  • Chloride Channel Accessory 4 2 3 4 5
  • CaCC2 2 3 4
  • Chloride Channel, Calcium Activated, Family Member 4 2 3
  • Calcium-Activated Chloride Channel Family Member 4 3 4
  • Calcium-Activated Chloride Channel Regulator 4 3 4
  • Calcium-Activated Chloride Channel Protein 2 3 4
  • Chloride Channel Regulator 4 2 3
  • HCaCC-2 3 4
  • CaCC-2 3 4
  • HCLCA4 3 4
  • EC 3.4.-.- 4
  • CLCA4 5
  • CaCC 3

External Ids for CLCA4 Gene

Previous GeneCards Identifiers for CLCA4 Gene

  • GC01P087514
  • GC01P086181
  • GC01P086305
  • GC01P086435
  • GC01P086724
  • GC01P087012
  • GC01P085123

Summaries for CLCA4 Gene

Entrez Gene Summary for CLCA4 Gene

  • The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008]

GeneCards Summary for CLCA4 Gene

CLCA4 (Chloride Channel Accessory 4) is a Protein Coding gene. Diseases associated with CLCA4 include Cystic Fibrosis and Cecum Carcinoma. Among its related pathways are Activation of cAMP-Dependent PKA and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and intracellular calcium activated chloride channel activity. An important paralog of this gene is CLCA1.

UniProtKB/Swiss-Prot Summary for CLCA4 Gene

Gene Wiki entry for CLCA4 Gene

Additional gene information for CLCA4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLCA4 Gene

Genomics for CLCA4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CLCA4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J086546 Promoter/Enhancer 0.7 EPDnew Ensembl ENCODE 600.7 +0.0 5 1.3 CLCA4 piR-31936-004 CDCA4P2 SH3GLB1
GH01J086548 Enhancer 0.2 ENCODE 600.7 +1.8 1819 1.1 CLCA4 CLCA3P CDCA4P2 SH3GLB1
GH01J086507 Enhancer 0.5 Ensembl 15.5 -39.1 -39058 0.8 CTCF REST RAD21 SMC3 ZNF654 CLCA4 CLCA2 CLCA1 LOC105378827 piR-50357-005
GH01J086517 Enhancer 0.4 Ensembl ENCODE 11.4 -29.6 -29577 1 JUND CLCA4 CLCA1 CLCA2 LOC105378826 piR-61614-004
GH01J086516 Enhancer 0.3 Ensembl 10.6 -31.0 -30977 0.2 CTCF CLCA1 CLCA4 CLCA2 LOC105378826 piR-61614-004
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLCA4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLCA4

Top Transcription factor binding sites by QIAGEN in the CLCA4 gene promoter:
  • Bach1
  • Bach2
  • Evi-1
  • FOXL1
  • JunD
  • LCR-F1
  • NF-E2
  • NF-E2 p45
  • POU3F1
  • S8

Genomic Locations for CLCA4 Gene

Genomic Locations for CLCA4 Gene
chr1:86,547,078-86,580,758
(GRCh38/hg38)
Size:
33,681 bases
Orientation:
Plus strand
chr1:87,012,759-87,046,437
(GRCh37/hg19)
Size:
33,679 bases
Orientation:
Plus strand

Genomic View for CLCA4 Gene

Genes around CLCA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLCA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLCA4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CLCA4 Gene

Proteins for CLCA4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CLCA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14CN2-CLCA4_HUMAN
    Recommended name:
    Calcium-activated chloride channel regulator 4
    Protein Accession:
    Q14CN2
    Secondary Accessions:
    • A8MQC9
    • B7Z1Q5
    • Q6UX81
    • Q9UNF7

    Protein attributes for CLCA4 Gene

    Size:
    919 amino acids
    Molecular mass:
    101283 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLCA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLCA4 Gene

Protein Expression for CLCA4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CLCA4 Gene

  • The translation product is autoproteolytically cleaved by the metalloprotease domain in the endoplasmic reticulum into a N-terminal and a C-terminal products that remain physically associated with each other. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.
  • Glycosylation at Asn340, Asn75, Asn504, Asn542, Asn588, Asn628, Asn811, Asn832, Asn837, and Asn852
  • Modification sites at PhosphoSitePlus

Other Protein References for CLCA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLCA4 Gene

Domains & Families for CLCA4 Gene

Gene Families for CLCA4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CLCA4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CLCA4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54980, highly similar to Homo sapiens chloride channel, calcium activated, family member 4 (CLCA4), mRNA (A8MQC9_HUMAN)
  • Calcium-activated chloride channel protein 2 (CLCA4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14CN2

UniProtKB/Swiss-Prot:

CLCA4_HUMAN :
  • The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA substrates.
  • Belongs to the CLCR family.
Domain:
  • The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA substrates.
Family:
  • Belongs to the CLCR family.
genes like me logo Genes that share domains with CLCA4: view

Function for CLCA4 Gene

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  2. CRISPR
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  6. Cell Line

Molecular function for CLCA4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in mediating calcium-activated chloride conductance.
UniProtKB/Swiss-Prot Induction:
Down-regulated in oral tongue squamous cell carcinomas.

Enzyme Numbers (IUBMB) for CLCA4 Gene

Phenotypes From GWAS Catalog for CLCA4 Gene

Gene Ontology (GO) - Molecular Function for CLCA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005229 intracellular calcium activated chloride channel activity IBA 21873635
GO:0005254 chloride channel activity TAS 10437792
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CLCA4: view
genes like me logo Genes that share phenotypes with CLCA4: view

Human Phenotype Ontology for CLCA4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CLCA4 Gene

MGI Knock Outs for CLCA4:

Animal Model Products

CRISPR Products

miRNA for CLCA4 Gene

miRTarBase miRNAs that target CLCA4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLCA4

No data available for Transcription Factor Targets and HOMER Transcription for CLCA4 Gene

Localization for CLCA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLCA4 Gene

Cell membrane. Single-pass membrane protein. Apical cell membrane. Secreted. Note=The C-terminus 30 kDa form is anchored to the membrane. The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLCA4 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Aggresome (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CLCA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLCA4: view

Pathways & Interactions for CLCA4 Gene

PathCards logo

SuperPathways for CLCA4 Gene

SuperPathway Contained pathways
1 Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
PKA Signaling
.56
2 Ion channel transport
Ion channel transport
.50
Stimuli-sensing channels
.50
3 Pancreatic secretion
Pancreatic secretion
-
4 Renin secretion
Renin secretion
-
5 Neuropathic Pain-Signaling in Dorsal Horn Neurons
Cholera Infection
.40
genes like me logo Genes that share pathways with CLCA4: view

Pathways by source for CLCA4 Gene

2 KEGG pathways for CLCA4 Gene
5 Qiagen pathways for CLCA4 Gene
  • Activation of cAMP-Dependent PKA
  • cAMP Pathway
  • Cholera Infection
  • Hepatic ABC Transporters
  • PKA Signaling

Interacting Proteins for CLCA4 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000359594 Q14CN2-CLCA4_HUMAN for CLCA4 Gene via STRING IID

GPS-Prot Interaction Network for CLCA4

Gene Ontology (GO) - Biological Process for CLCA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006821 chloride transport IEA --
GO:0034220 ion transmembrane transport TAS --
GO:1902476 chloride transmembrane transport IEA --
genes like me logo Genes that share ontologies with CLCA4: view

No data available for SIGNOR curated interactions for CLCA4 Gene

Drugs & Compounds for CLCA4 Gene

Products:

  1. Drug

(6) Drugs for CLCA4 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Talniflumate Experimental Pharma CaCC blocker and Cl-/HCO3- exchange inhibitor 0
Chloride ion Experimental Pharma 0
CaCCinh-A01 Pharma 0
Eact Pharma Activator of Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) 0
T16Ainh - A01 Pharma 0

(4) ApexBio Compounds for CLCA4 Gene

Compound Action Cas Number
CaCCinh-A01 407587-33-1
Eact 461000-66-8
T16Ainh - A01 552309-42-9
Talniflumate 66898-62-2
genes like me logo Genes that share compounds with CLCA4: view

Drug Products

Transcripts for CLCA4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CLCA4 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLCA4

Alternative Splicing Database (ASD) splice patterns (SP) for CLCA4 Gene

No ASD Table

Relevant External Links for CLCA4 Gene

GeneLoc Exon Structure for
CLCA4

Expression for CLCA4 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLCA4 Gene

mRNA expression in normal human tissues for CLCA4 Gene
mRNA expression by BioGPS for CLCA4 GenemRNA expression by GTEx for CLCA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLCA4 Gene

This gene is overexpressed in Esophagus - Mucosa (x22.8), Colon - Transverse (x13.3), and Minor Salivary Gland (x6.0).

Protein differential expression in normal tissues from HIPED for CLCA4 Gene

This gene is overexpressed in Cervix (39.6), Nasal epithelium (13.0), and Colon (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLCA4 Gene



Protein tissue co-expression partners for CLCA4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLCA4

SOURCE GeneReport for Unigene cluster for CLCA4 Gene:

Hs.567422

mRNA Expression by UniProt/SwissProt for CLCA4 Gene:

Q14CN2-CLCA4_HUMAN
Tissue specificity: Primarily expressed in the digestive tract, mainly in colon. Detected in smaller amounts in brain, urogenital organs, testis, and salivary and mammary glands. Highly expressed in the epithelial layer and submucosal gland of the inferior turbinate mucosa. Lower levels in the epithelial layer of nasal polyp.

Evidence on tissue expression from TISSUES for CLCA4 Gene

  • Intestine(4.6)
  • Nervous system(4.3)
  • Saliva(4)
genes like me logo Genes that share expression patterns with CLCA4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CLCA4 Gene

Orthologs for CLCA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLCA4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CLCA4 30 31
  • 98.95 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CLCA4 30 31
  • 85.32 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CLCA4 30 31
  • 82.39 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia AI747448 30 31
  • 76.9 (n)
 OneToMany
Gm6289 31
  • 70 (a)
 OneToMany
Clca6 31
  • 69 (a)
 OneToMany
Clca4a 17
Clca4b 17
Rat
(Rattus norvegicus)
 Mammalia Clca4 30
  • 76.67 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 56 (a)
 ManyToMany
-- 31
  • 55 (a)
 ManyToMany
-- 31
  • 54 (a)
 ManyToMany
-- 31
  • 53 (a)
 ManyToMany
-- 31
  • 47 (a)
 ManyToMany
-- 31
  • 44 (a)
 ManyToMany
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 49 (a)
 ManyToMany
-- 31
  • 38 (a)
 ManyToMany
Chicken
(Gallus gallus)
 Aves -- 31
  • 47 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 47 (a)
 ManyToMany
-- 31
  • 47 (a)
 ManyToMany
-- 31
  • 47 (a)
 ManyToMany
-- 31
  • 45 (a)
 ManyToMany
-- 31
  • 44 (a)
 ManyToMany
-- 31
  • 44 (a)
 ManyToMany
-- 31
  • 44 (a)
 ManyToMany
-- 31
  • 44 (a)
 ManyToMany
-- 31
  • 41 (a)
 ManyToMany
Zebrafish
(Danio rerio)
 Actinopterygii si:dkey-243k1.4 31
  • 41 (a)
 ManyToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 38 (a)
 ManyToMany
-- 31
  • 33 (a)
 ManyToMany
-- 31
  • 29 (a)
 ManyToMany
-- 31
  • 28 (a)
 ManyToMany
-- 31
  • 26 (a)
 ManyToMany
Species where no ortholog for CLCA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CLCA4 Gene

ENSEMBL:
Gene Tree for CLCA4 (if available)
TreeFam:
Gene Tree for CLCA4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLCA4: view image

Paralogs for CLCA4 Gene

Paralogs for CLCA4 Gene

(3) SIMAP similar genes for CLCA4 Gene using alignment to 3 proteins:

  • CLCA4_HUMAN
  • A8MQC9_HUMAN
  • L8ECE0_HUMAN

Pseudogenes.org Pseudogenes for CLCA4 Gene

genes like me logo Genes that share paralogs with CLCA4: view

Variants for CLCA4 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLCA4 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
737467 Benign: not provided 86,565,961(+) T/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
773148 Benign: not provided 86,560,249(+) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
775566 Likely Benign: not provided 86,560,314(+) CT/C FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
788077 Benign: not provided 86,574,546(+) A/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs1011048 - p.Met449Leu

Additional dbSNP identifiers (rs#s) for CLCA4 Gene

Structural Variations from Database of Genomic Variants (DGV) for CLCA4 Gene

Variant ID Type Subtype PubMed ID
dgv357n54 CNV loss 21841781
dgv358n54 CNV loss 21841781
dgv61e212 CNV loss 25503493
esv2670523 CNV deletion 23128226
esv2761188 CNV gain+loss 21179565
esv3565359 CNV deletion 23714750
esv3586700 CNV gain 21293372
esv3586701 CNV loss 21293372
nsv546759 CNV loss 21841781
nsv546760 CNV gain 21841781
nsv546761 CNV loss 21841781
nsv546764 CNV loss 21841781
nsv546767 CNV loss 21841781
nsv546771 CNV loss 21841781
nsv823464 CNV loss 20364138

Variation tolerance for CLCA4 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLCA4 Gene

Human Gene Mutation Database (HGMD)
CLCA4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLCA4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLCA4 Gene

Disorders for CLCA4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CLCA4 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cystic fibrosis
  • cf
cecum carcinoma
  • caecum carcinoma
cecum adenocarcinoma
  • cecal adenocarcinoma
colon mucinous adenocarcinoma
  • colonic mucinous adenocarcinoma
cribriform carcinoma
  • ductal carcinoma, cribriform type
- elite association - COSMIC cancer census association via MalaCards
Search CLCA4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CLCA4

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CLCA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLCA4 Gene

Publications for CLCA4 Gene

  1. Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea. (PMID: 10437792) Agnel M … Culouscou JM (FEBS letters 1999) 2 3 4
  2. The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis. (PMID: 15490240) Ritzka M … Tümmler B (Human genetics 2004) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Calcium-Activated Chloride Channel A4 (CLCA4) Plays Inhibitory Roles in Invasion and Migration Through Suppressing Epithelial-Mesenchymal Transition via PI3K/AKT Signaling in Colorectal Cancer. (PMID: 31164625) Chen H … Liu QA (Medical science monitor : international medical journal of experimental and clinical research 2019) 3

ExternalLinks

View latest publications for CLCA4 gene in Mastermind

Products for CLCA4 Gene

  • Signalway Proteins for CLCA4

Sources for CLCA4 Gene