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This gene is a transcribed pseudogene belonging to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. This gene contains several nonsense codons compared to other family members that render the transcript a candidate for nonsense-mediated mRNA decay (NMD). Therefore, this gene is unlikely to be protein-coding. [provided by RefSeq, Jan 2009]
CLCA3P (Chloride Channel Accessory 3, Pseudogene) is a Pseudogene. Among its related pathways are Activation of cAMP-Dependent PKA and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Gene Ontology (GO) annotations related to this gene include transporter activity and chloride channel activity.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J086542 | Enhancer | 0.3 | Ensembl ENCODE | 5.8 | -91.2 | -91234 | 1.5 | CLCA3P CLCA4 piR-31936-004 piR-31470-022 CLCA1 | ||
GH01J086548 | Enhancer | 0.2 | ENCODE | 5.4 | -85.4 | -85376 | 1.1 | CLCA4 CLCA3P CDCA4P2 SH3GLB1 | ||
GH01J086648 | Enhancer | 0.5 | Ensembl | 0.4 | +14.1 | 14128 | 1.2 | CEBPB FOS FOSL1 BHLHE40 JUN JUND | ENSG00000261737 CLCA3P piR-55194-011 CLCA4-AS1 SH3GLB1 CLCA4 | |
GH01J086636 | Enhancer | 0.2 | ENCODE | 0.7 | +2.8 | 2760 | 0.2 | CLCA3P piR-55194-011 SH3GLB1 CLCA4-AS1 CLCA4 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005215 | transporter activity | TAS | 10095065 |
GO:0005244 | voltage-gated ion channel activity | IEA | -- |
GO:0005254 | chloride channel activity | IEA | -- |
GO:0005262 | calcium channel activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | TAS | 10095065 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0034707 | chloride channel complex | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
PKA Signaling
.56
|
2 | Ion channel transport | ||
3 | Neuropathic Pain-Signaling in Dorsal Horn Neurons |
Cholera Infection
.40
|
|
4 | Hepatic ABC Transporters |
Hepatic ABC Transporters
.41
|
|
5 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0034220 | ion transmembrane transport | TAS | -- |
GO:0034765 | regulation of ion transmembrane transport | IEA | -- |
GO:0070588 | calcium ion transmembrane transport | IEA | -- |
GO:1902476 | chloride transmembrane transport | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
GlyH 101 |
|
328541-79-3 |
|
|
Compound | Action | Cas Number |
---|---|---|
CFTRinh 172 | Voltage-independent, selective CFTR chloride channel blocker | 307510-92-5 |
DCEBIO | Activates Cl- conductance and hKCa3.1 channels | 60563-36-2 |
GlyH 101 | Reversible, voltage-dependent CFTR chloride channel blocker | 328541-79-3 |
PPQ 102 | Potent, voltage-independent CFTR chloride channel inhibitor | 931706-15-9 |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2714407 | CNV | deletion | 23290073 |
esv2761188 | CNV | gain+loss | 21179565 |
esv3586705 | CNV | loss | 21293372 |
esv3586706 | CNV | loss | 21293372 |
nsv546760 | CNV | gain | 21841781 |
No disorders were found for CLCA3P Gene.