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This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA... See more...
Aliases for CLCA2 Gene
Aliases for CLCA2 Gene
External Ids for CLCA2 Gene
- HGNC: 2016
- Entrez Gene: 9635
- Ensembl: ENSG00000137975
- OMIM: 604003
- UniProtKB: Q9UQC9
Previous GeneCards Identifiers for CLCA2 Gene
- GC01P087392
- GC01P086058
- GC01P086182
- GC01P086312
- GC01P086601
- GC01P086889
- GC01P085000
Summaries for CLCA2 Gene
-
This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep 2016]
GeneCards Summary for CLCA2 Gene
CLCA2 (Chloride Channel Accessory 2) is a Protein Coding gene. Diseases associated with CLCA2 include Familial Adenomatous Polyposis 2 and Breast Cancer. Among its related pathways are Activation of cAMP-Dependent PKA and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and intracellular calcium activated chloride channel activity. An important paralog of this gene is CLCA1.
UniProtKB/Swiss-Prot Summary for CLCA2 Gene
-
Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.
-
Chloride channels are a family of anion-selective channels involved in a diverse range of biological processes including the regulation of the excitability of neurons, skeletal, cardiac and smooth muscle, cell volume regulation, transepithelial salt transport, the acidification of intra- and extracellular compartments.
Additional gene information for CLCA2 Gene
- HGNC(2016)
- Entrez Gene(9635)
- Ensembl(ENSG00000137975)
- OMIM(604003)
- UniProtKB(Q9UQC9)
- Open Targets Platform(ENSG00000137975)
- Monarch Initiative
- Search for CLCA2 at DataMed
- Search for CLCA2 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLCA2 Gene
Genomics for CLCA2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CLCA2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J086421 | Promoter/Enhancer | 1.3 | EPDnew Ensembl ENCODE | 624.3 | -0.5 | -476 | 4.5 | JUND EP300 STAT1 TBP | CLCA2 ODF2L CLCA1 LOC100420166 | |
| GH01J086393 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE CraniofacialAtlas | 23 | -28.5 | -28526 | 4.4 | CREB1 TEAD4 PRDM10 ZNF629 RFX1 ZNF692 POLR2A ZHX2 FOXA1 ZNF143 | ODF2L CLCA2 piR-50852-003 COL24A1 | |
| GH01J086428 | Enhancer | 1 | Ensembl ENCODE | 24.3 | +6.0 | 5956 | 3 | CEBPG JUND FOXA1 GABPA ETV6 CEBPA EP300 SCRT2 CEBPB NFE2 | ODF2L CLCA2 CLCA1 | |
| GH01J086416 | Enhancer | 0.5 | Ensembl | 23.6 | -7.6 | -7643 | 0.2 | POLR2A MNT ZBTB20 ZNF366 HLF RAD51 USF2 SP7 | CLCA2 ODF2L LOC100420166 | |
| GH01J086382 | Promoter | 0.5 | Ensembl | 22.9 | -41.0 | -41043 | 0.6 | ZBTB40 TBP | CLCA2 piR-50852-003 ODF2L lnc-COL24A1-3 COL24A1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CLCA2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLCA2
- Top Transcription factor binding sites by QIAGEN in the CLCA2 gene promoter:
-
- FOXD3
- FOXJ2 (long isoform)
- GR
- GR-alpha
- GR-beta
- ITF-2
- Pbx1a
- Tal-1beta
- TGIF
- ZID
Genomic Locations for CLCA2 Gene
Genomic Locations for CLCA2 Gene
- chr1:86,424,144-86,456,553
- (GRCh38/hg38)
- Size:
- 32,410 bases
- Orientation:
- Plus strand
- chr1:86,889,769-86,922,241
- (GRCh37/hg19)
- Size:
- 32,473 bases
- Orientation:
- Plus strand
Genomic View for CLCA2 Gene
Genes around CLCA2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p22.3 by HGNC
- 1p22.3 by Entrez Gene
- 1p22.3 by Ensembl
CLCA2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CLCA2 Gene
Proteins for CLCA2 Gene
-
Protein details for CLCA2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UQC9-CLCA2_HUMAN
- Recommended name:
- Calcium-activated chloride channel regulator 2
- Protein Accession:
- Q9UQC9
- A8K2T3
- Q9Y6N2
Protein attributes for CLCA2 Gene
- Size:
- 943 amino acids
- Molecular mass:
- 103941 Da
- Quaternary structure:
- No Data Available
Protein Expression for CLCA2 Gene
Post-translational modifications for CLCA2 Gene
- The 141 kDa mature form is autoproteolytically cleaved by the metalloprotease domain, producing a 109 kDa form and a 35 kDa form. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.
- N-glycosylated.
-
Glycosylation at Asn74, Asn150, Asn231, Asn522, Asn637, and Asn822
- NX_Q9UQC9 (NX_Q9UQC9-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- CLCA2_HUMAN (1057)
Other Protein References for CLCA2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CLCA2
- Novus Biologicals Antibodies for CLCA2
-
Abcam antibodies for CLCA2
- Invitrogen Antibodies for CLCA2 (AFLGC-CLCA2)
- antibodies-online: Show 18 available CLCA2 Antibodies ranked by validation data
- Compare Top CLCA2 Antibodies
-
Quality Products:
-
Santa Cruz Biotechnology (SCBT) Antibodies for CLCA2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CLCA2
- Origene Custom Protein Services for CLCA2
- antibodies-online: Show 6 available CLCA2 Proteins ranked by validation data
- Compare Top CLCA2 Proteins
-
Quality Products:
-
Abcam proteins for CLCA2
No data available for DME Specific Peptides for CLCA2 Gene
Domains & Families for CLCA2 Gene
Gene Families for CLCA2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for CLCA2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CLCA2 Gene
- GenScript: Design optimal peptide antigens:
-
- Calcium-activated chloride channel protein 3 (CLCA2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UQC9UniProtKB/Swiss-Prot:
CLCA2_HUMAN :- The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA substrates.
- Belongs to the CLCR family.
- Domain:
-
- The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA substrates.
- Family:
-
- Belongs to the CLCR family.
Function for CLCA2 Gene
Molecular function for CLCA2 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.
- UniProtKB/Swiss-Prot Induction:
- Significantly down-regulated in breast and colorectal cancer.
- GENATLAS Biochemistry:
- chloride channel Ca2+ activated family member 2,outwardly rectifiying,expressed in lung,trachea,mammary gland,epithelial cells
Enzyme Numbers (IUBMB) for CLCA2 Gene
Phenotypes From GWAS Catalog for CLCA2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005229 | intracellular calcium activated chloride channel activity | IBA | 21873635 |
| GO:0005254 | chloride channel activity | IEA,TAS | 10362588 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008237 | metallopeptidase activity | IEA | -- |
| GO:0015276 | ligand-gated ion channel activity | IEA | -- |
Phenotypes for CLCA2 Gene
- MGI mutant phenotypes for CLCA2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CLCA2:
Animal Models for CLCA2 Gene
- MGI Knock Outs for CLCA2:
-
- Clca2 Clca2<tm1Dgen>
Animal Model Products
-
Taconic Biosciences Mouse Models for CLCA2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CLCA2 - Select products 50% OFF >
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-
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLCA2
-
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miRNA for CLCA2 Gene
- miRTarBase miRNAs that target CLCA2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLCA2
- Browse OriGene Inhibitory RNA Products For CLCA2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLCA2
Clone Products
- Applied Biological Materials (abm): Clones for CLCA2 - Select products 50% OFF >
- * CLCA2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CLCA2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLCA2
Cell Line Products
-
Horizon Cell Lines for CLCA2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLCA2 Gene
Localization for CLCA2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CLCA2 Gene
- Cell membrane. Single-pass type I membrane protein. Basal cell membrane. Single-pass type I membrane protein. Cell junction.
- [Calcium-activated chloride channel regulator 2, 109 kDa form]: Secreted. Note=Remains associated to the 35 kDa form until an unidentified event triggers the release.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 4 |
| cytosol | 4 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cell Junctions (3)
- Plasma membrane (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS,IBA | 21873635 |
Pathways & Interactions for CLCA2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
PKA Signaling
.56
|
| 2 | Ion channel transport | ||
| 3 | Pancreatic secretion | ||
| 4 | Renin secretion | ||
| 5 | Neuropathic Pain-Signaling in Dorsal Horn Neurons |
Cholera Infection
.40
|
|
Pathways by source for CLCA2 Gene
3 Reactome pathways for CLCA2 Gene
2 KEGG pathways for CLCA2 Gene
1 GeneGo (Thomson Reuters) pathway for CLCA2 Gene
- CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
5 Qiagen pathways for CLCA2 Gene
- Activation of cAMP-Dependent PKA
- cAMP Pathway
- Cholera Infection
- Hepatic ABC Transporters
- PKA Signaling
Interacting Proteins for CLCA2 Gene
GPS-Prot Interaction Network for CLCA2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006821 | chloride transport | IEA | -- |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0034220 | ion transmembrane transport | TAS | -- |
No data available for SIGNOR curated interactions for CLCA2 Gene
Drugs & Compounds for CLCA2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Talniflumate | Experimental | Pharma | CaCC blocker and Cl-/HCO3- exchange inhibitor | 0 | ||
| Chloride ion | Experimental | Pharma | 0 | |||
| CaCCinh-A01 | Pharma | 0 | ||||
| Eact | Pharma | Activator of Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) | 0 | |||
| T16Ainh - A01 | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| GlyH 101 |
|
328541-79-3 |
|
|
(4) Tocris Compounds for CLCA2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CFTRinh 172 | Voltage-independent, selective CFTR chloride channel blocker | 307510-92-5 |
| DCEBIO | Activates Cl- conductance and hKCa3.1 channels | 60563-36-2 |
| GlyH 101 | Reversible, voltage-dependent CFTR chloride channel blocker | 328541-79-3 |
| PPQ 102 | Potent, voltage-independent CFTR chloride channel inhibitor | 931706-15-9 |
(4) ApexBio Compounds for CLCA2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CaCCinh-A01 | 407587-33-1 | |
| Eact | 461000-66-8 | |
| T16Ainh - A01 | 552309-42-9 | |
| Talniflumate | 66898-62-2 |
Transcripts for CLCA2 Gene
mRNA/cDNA for CLCA2 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000370565 3935 nts (view in UCSC)
- ENST00000490884 514 nts (view in UCSC)
- ENST00000498802 740 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CLCA2 - Select products 50% OFF >
- * CLCA2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CLCA2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLCA2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CLCA2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLCA2
- Browse OriGene Inhibitory RNA Products For CLCA2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLCA2
Clone Products
- Applied Biological Materials (abm): Clones for CLCA2 - Select products 50% OFF >
- * CLCA2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CLCA2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLCA2
Relevant External Links for CLCA2 Gene
- GeneLoc Exon Structure for
- CLCA2
Expression for CLCA2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Epithelial Cells
- Basal Cells Trachea
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Brain (Nervous System)
- Pancreas (Endocrine System)
- Epidermis (Integumentary System)
- Hair
mRNA differential expression in normal tissues according to GTEx for CLCA2 Gene
This gene is overexpressed in Esophagus - Mucosa (x20.3), Vagina (x7.9), Skin - Not Sun Exposed (Suprapubic) (x7.6), and Skin - Sun Exposed (Lower leg) (x6.7).
This gene is overexpressed in Bone (22.1), Skin (16.6), Esophagus (10.2), and Oral epithelium (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLCA2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLCA2
SOURCE GeneReport for Unigene cluster for CLCA2 Gene:
Hs.241551mRNA Expression by UniProt/SwissProt for CLCA2 Gene:
Q9UQC9-CLCA2_HUMAN
Tissue specificity:
Expressed in cornea, skin, vagina, esophagus, and larynx (at protein level). Expressed in trachea and mammary gland. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium, colon and trachea. Moderately expressed in brain, urogenital organs, bladder, uterus and prostate. Highly expressed in tissues containing stratified epithelium including cornea, esophagus, larynx, skin and vagina than those tissues which contain only epithelial monolayers. Expressed in normal breast epithelium but not in breast cancer. Highly expressed during epithelial stratification. Expressed in endothelial cells of lung. Expressed selectively in endothelia of small pulmonary arteries, arterioles, and subpleural and interlobular venules.
Evidence on tissue expression from TISSUES for CLCA2 Gene
- Lung(4.5)
- Nervous system(4.3)
- Eye(4.2)
- Skin(2.8)
Primer Products
-
OriGene qPCR primer pairs for CLCA2
-
OriGene qPCR primer pairs and template standards for CLCA2
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLCA2 Gene
Orthologs for CLCA2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CLCA2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CLCA2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CLCA2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Clca5 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Clca5 30 31 |
|
OneToOne | |
| Clca2 17 |
|
||||
| Oppossum (Monodelphis domestica) |
Mammalia | CLCA2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CLCA2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CLCA2 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.15133 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-116o3.3 31 |
|
ManyToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany |
- Species where no ortholog for CLCA2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CLCA2 Gene
- ENSEMBL:
- Gene Tree for CLCA2 (if available)
- TreeFam:
- Gene Tree for CLCA2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CLCA2: view image
Paralogs for CLCA2 Gene
Variants for CLCA2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLCA2 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 747892 | Likely Benign: not provided | 86,430,908(+) | C/T | SYNONYMOUS_VARIANT | |
| 773147 | Benign: not provided | 86,428,558(+) | C/T | SYNONYMOUS_VARIANT | |
| 783291 | Benign: not provided | 86,455,230(+) | G/A | SYNONYMOUS_VARIANT | |
| VAR_043149 | A breast cancer sample | p.Gly754Glu | |||
| rs11580625 | - | p.Val80Ile |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3582026 | CNV | gain | 25503493 |
| nsv1002541 | CNV | gain | 25217958 |
| nsv1161035 | CNV | duplication | 26073780 |
| nsv521366 | CNV | loss | 19592680 |
| nsv546722 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.91;
91.89% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CLCA2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLCA2 Gene
Disorders for CLCA2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| familial adenomatous polyposis 2 |
|
|
| breast cancer |
|
|
| progressive familial heart block, type ib |
|
|
| maxillary cancer |
|
|
| jaw cancer |
|
|
Search CLCA2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CLCA2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CLCA2 Gene
Publications for CLCA2 Gene
- The quantification of hCLCA2 and colocalisation with integrin beta4 in stratified human epithelia. (PMID: 15707651) Connon CJ … Kinoshita S (Acta histochemica 2005) 3 4 23
- Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea. (PMID: 10437792) Agnel M … Culouscou JM (FEBS letters 1999) 3 4 23
- Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41
- Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 41
- Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PMID: 18950845) Vega A … Carracedo A (Gynecologic oncology 2009) 3 41
ExternalLinks
Products for CLCA2 Gene
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- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CLCA2
- Origene Custom Protein Services for CLCA2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CLCA2
- Browse OriGene Inhibitory RNA Products For CLCA2
- OriGene qPCR primer pairs for CLCA2
- OriGene qPCR primer pairs and template standards for CLCA2
- OriGene CRISPR knockouts for CLCA2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CLCA2
- Sino Biological Human cDNA Clone for CLCA2
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CLCA2
- Novus Biologicals proteins and lysates for CLCA2
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- Abcam antibodies for CLCA2
- Abcam proteins for CLCA2
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- Taconic Biosciences Mouse Models for CLCA2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CLCA2 (AFLGC-CLCA2)
- ApexBio compounds for CLCA2
- VectorBuilder Custom and pre-made DNA vectors for CLCA2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CLCA2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CLCA2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CLCA2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CLCA2
- antibodies-online: Show 18 available CLCA2 Antibodies ranked by validation data
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- antibodies-online: Search results for available CLCA2 related products ranked by validation data
- antibodies-online: Show 6 available CLCA2 Proteins ranked by validation data
- Compare Top CLCA2 Proteins
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- Santa Cruz Biotechnology (SCBT) Antibodies for CLCA2
- Search Santa Cruz Biotechnology (SCBT) for CLCA2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CLCA2
- Horizon Cell Lines for CLCA2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CLCA2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CLCA2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CLCA2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLCA2
Sources for CLCA2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB