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Aliases for CLASRP Gene

Aliases for CLASRP Gene

  • CLK4 Associating Serine/Arginine Rich Protein 2 3 5
  • CLK4-Associating Serine/Arginine Rich Protein 2 3
  • Splicing Factor, Arginine/Serine-Rich 16 2 4
  • Clk4 Associating SR-Related Protein 2 3
  • SFRS16 3 4
  • SWAP2 3 4
  • Splicing Factor, Arginine/Serine-Rich 16 (Suppressor-Of-White-Apricot Homolog, Drosophila) 3
  • Suppressor Of White Apricot Homolog 2 3
  • Suppressor Of White-Apricot Homolog 2 4
  • CLASP 3

External Ids for CLASRP Gene

Previous HGNC Symbols for CLASRP Gene

  • SFRS16

Previous GeneCards Identifiers for CLASRP Gene

  • GC19P045545

Summaries for CLASRP Gene

GeneCards Summary for CLASRP Gene

CLASRP (CLK4 Associating Serine/Arginine Rich Protein) is a Protein Coding gene. Diseases associated with CLASRP include Charcot-Marie-Tooth Disease, Axonal, Type 2D. Among its related pathways are mRNA Splicing - Major Pathway.

UniProtKB/Swiss-Prot for CLASRP Gene

  • Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity).

Gene Wiki entry for CLASRP Gene

Additional gene information for CLASRP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLASRP Gene

Genomics for CLASRP Gene

GeneHancer (GH) Regulatory Elements for CLASRP Gene

Promoters and enhancers for CLASRP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J045038 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 664 +1.0 1026 3.9 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YBX1 YY1 POLR2B ZNF213 CLASRP ZNF180 ZNF225 ZNF284 ZNF224 ZNF223 ZNF235 ZNF234 ZNF227 ZNF226
GH19J044844 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 87.8 -191.0 -191026 7.3 YBX1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 MCM3 SP3 ZNF610 NECTIN2 GC19P044850 ZNF180 ZNF45 ZNF225 CLASRP ZNF224 ZNF234 ZNF284 FBXO46
GH19J044740 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 73.4 -289.0 -289023 19.4 YBX1 FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 SP3 BCL3 ZNF45 ZNF180 ZNF155 ZNF224 ZNF284 CLASRP ZNF225 ZNF234 FBXO46
GH19J045401 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 73.8 +365.5 365532 6.2 CLOCK FEZF1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D GLIS1 RCOR2 CD3EAP PPP1R13L CCDC61 ZNF180 CLASRP FBXO46 ENSG00000269148 ENSG00000268810 SYMPK IRF2BP1
GH19J044259 Promoter/Enhancer 1.5 Ensembl ENCODE 93.2 -779.0 -779008 1.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 ZBTB7B ZNF233 ZNF45 ZNF180 ZNF224 ZNF225 ZNF284 ZNF234 CLASRP ZNF227 ZNF235
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLASRP on UCSC Golden Path with GeneCards custom track

Genomic Locations for CLASRP Gene

Genomic Locations for CLASRP Gene
chr19:45,039,040-45,070,956
(GRCh38/hg38)
Size:
31,917 bases
Orientation:
Plus strand
chr19:45,542,298-45,574,214
(GRCh37/hg19)
Size:
31,917 bases
Orientation:
Plus strand

Genomic View for CLASRP Gene

Genes around CLASRP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLASRP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLASRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLASRP Gene

Proteins for CLASRP Gene

  • Protein details for CLASRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2M8-CLASR_HUMAN
    Recommended name:
    CLK4-associating serine/arginine rich protein
    Protein Accession:
    Q8N2M8
    Secondary Accessions:
    • B4DDT8
    • F8WAG9
    • O96026
    • Q6UW71
    • Q96DX2

    Protein attributes for CLASRP Gene

    Size:
    674 amino acids
    Molecular mass:
    77161 Da
    Quaternary structure:
    • Probably interacts with CLK4.
    SequenceCaution:
    • Sequence=AAC82339.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC82340.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH80554.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CLASRP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLASRP Gene

Post-translational modifications for CLASRP Gene

No data available for DME Specific Peptides for CLASRP Gene

Domains & Families for CLASRP Gene

Gene Families for CLASRP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CLASRP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CLASRP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N2M8

UniProtKB/Swiss-Prot:

CLASR_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with CLASRP: view

Function for CLASRP Gene

Molecular function for CLASRP Gene

UniProtKB/Swiss-Prot Function:
Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity).

Phenotypes From GWAS Catalog for CLASRP Gene

Gene Ontology (GO) - Molecular Function for CLASRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27173435
genes like me logo Genes that share ontologies with CLASRP: view
genes like me logo Genes that share phenotypes with CLASRP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLASRP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLASRP Gene

Localization for CLASRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLASRP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLASRP gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CLASRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with CLASRP: view

Pathways & Interactions for CLASRP Gene

SuperPathways for CLASRP Gene

SuperPathway Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with CLASRP: view

Pathways by source for CLASRP Gene

1 BioSystems pathway for CLASRP Gene

Gene Ontology (GO) - Biological Process for CLASRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with CLASRP: view

No data available for SIGNOR curated interactions for CLASRP Gene

Drugs & Compounds for CLASRP Gene

No Compound Related Data Available

Transcripts for CLASRP Gene

mRNA/cDNA for CLASRP Gene

Unigene Clusters for CLASRP Gene

CLK4-associating serine/arginine rich protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLASRP

Alternative Splicing Database (ASD) splice patterns (SP) for CLASRP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: -
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8: -
SP9:

ExUns: 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CLASRP Gene

GeneLoc Exon Structure for
CLASRP
ECgene alternative splicing isoforms for
CLASRP

Expression for CLASRP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLASRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLASRP Gene

This gene is overexpressed in Plasma (26.2), Peripheral blood mononuclear cells (11.2), and Fetal ovary (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CLASRP Gene



Protein tissue co-expression partners for CLASRP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLASRP Gene:

CLASRP

SOURCE GeneReport for Unigene cluster for CLASRP Gene:

Hs.466917

Evidence on tissue expression from TISSUES for CLASRP Gene

  • Skin(4.4)
  • Liver(4.2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with CLASRP: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLASRP Gene

Orthologs for CLASRP Gene

This gene was present in the common ancestor of animals.

Orthologs for CLASRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLASRP 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLASRP 34
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clasrp 34
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLASRP 34
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLASRP 34
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLASRP 34
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii clasrp 34
  • 71 (a)
OneToOne
Dr.16226 33
fruit fly
(Drosophila melanogaster)
Insecta CG6695 34
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F28C1.1 34
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2291 34
  • 37 (a)
OneToOne
Species where no ortholog for CLASRP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CLASRP Gene

ENSEMBL:
Gene Tree for CLASRP (if available)
TreeFam:
Gene Tree for CLASRP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLASRP: view image

Paralogs for CLASRP Gene

No data available for Paralogs for CLASRP Gene

Variants for CLASRP Gene

Sequence variations from dbSNP and Humsavar for CLASRP Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
VAR_035490 A breast cancer sample p.Leu213Ser
rs1000040810 -- 45,045,290(+) A/G intron_variant
rs1000053568 -- 45,038,792(+) G/A upstream_transcript_variant
rs1000123908 -- 45,050,637(+) T/C intron_variant
rs1000209063 -- 45,046,160(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CLASRP Gene

Variant ID Type Subtype PubMed ID
esv3583432 CNV loss 25503493
nsv1138710 CNV deletion 24896259
nsv953587 CNV deletion 24416366

Variation tolerance for CLASRP Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLASRP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLASRP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLASRP Gene

Disorders for CLASRP Gene

MalaCards: The human disease database

(1) MalaCards diseases for CLASRP Gene - From: DISEASES

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, axonal, type 2d
  • cmt2d
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CLASRP

genes like me logo Genes that share disorders with CLASRP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLASRP Gene

Publications for CLASRP Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Novel SR-rich-related protein clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk. (PMID: 12169693) Katsu R … Hagiwara M (The Journal of biological chemistry 2002) 2 3 58

Products for CLASRP Gene

Sources for CLASRP Gene

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