Aliases for CLASP1 Gene
External Ids for CLASP1 Gene
Previous GeneCards Identifiers for CLASP1 Gene
CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CLASP1 Gene
CLASP1 (Cytoplasmic Linker Associated Protein 1) is a Protein Coding gene. Diseases associated with CLASP1 include Roifman Syndrome and Theileriasis. Among its related pathways are Signaling by Robo receptor and Signaling by Slit. Gene Ontology (GO) annotations related to this gene include binding and microtubule plus-end binding. An important paralog of this gene is CLASP2.
UniProtKB/Swiss-Prot Summary for CLASP1 Gene
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.