CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only on... See more...

Aliases for CKS1B Gene

Aliases for CKS1B Gene

  • CDC28 Protein Kinase Regulatory Subunit 1B 2 3 5
  • CKS1 2 3 4
  • Cyclin-Dependent Kinases Regulatory Subunit 1 3 4
  • CDC28 Protein Kinase 1B 2 3
  • Ckshs1 2 3
  • NB4 Apoptosis/Differentiation Related Protein 3
  • Cell Division Control Protein CKS1 3
  • CDC2-Associated Protein CKS1 3
  • PNAS-16 3
  • PNAS-18 3
  • CKS1B 5
  • CKS-1 4

External Ids for CKS1B Gene

Previous GeneCards Identifiers for CKS1B Gene

  • GC05M061960
  • GC01P150678
  • GC01P151722
  • GC01P152163
  • GC01P151760
  • GC01P153213
  • GC01P154947
  • GC01P126308

Summaries for CKS1B Gene

Entrez Gene Summary for CKS1B Gene

  • CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]

GeneCards Summary for CKS1B Gene

CKS1B (CDC28 Protein Kinase Regulatory Subunit 1B) is a Protein Coding gene. Diseases associated with CKS1B include Clear Cell Adenofibroma and Ceroid Lipofuscinosis, Neuronal, 2. Among its related pathways are Cell Cycle, Mitotic and Small cell lung cancer. Gene Ontology (GO) annotations related to this gene include kinase activity and cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CKS2.

UniProtKB/Swiss-Prot Summary for CKS1B Gene

  • Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

Gene Wiki entry for CKS1B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CKS1B Gene

Genomics for CKS1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CKS1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J154965 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 -2.6 -2599 12.2 BCLAF1 SP1 ZNF207 IKZF1 MYC NCOR1 ZNF600 SSRP1 JUND ZNF580 SHC1 CKS1B HSALNG0007448 GON4L CLK2 UBAP2L KHDC4 ENSG00000271267 THBS3 RUSC1-AS1
GH01J154848 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 5 -126.9 -126852 5.6 BCLAF1 SP1 JUND NFIC ZIC2 BCL11A TRIM22 IRF4 EBF1 BHLHE40 KCNN3 UBE2Q1 CHRNB2 ADAR UBE2Q1-AS1 ADAM15 CKS1B TDRD10 RF00017-310 HSALNG0007431
GH01J154998 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.5 +31.9 31874 15.9 BCLAF1 SP1 ZNF207 ZNF654 NCOR1 MYC ZNF600 IKZF1 SIX5 ZNF580 ZBTB7B CLK2 KHDC4 GON4L ENSG00000271267 UBAP2L RUSC1-AS1 MSTO1 MSTO2P ASH1L-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CKS1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CKS1B

Top Transcription factor binding sites by QIAGEN in the CKS1B gene promoter:
  • AP-1
  • c-Myb
  • c-Rel
  • HOXA5
  • MAZR
  • p53
  • Pax-4a
  • STAT3

Genomic Locations for CKS1B Gene

Latest Assembly
chr1:154,974,653-154,979,251
(GRCh38/hg38)
Size:
4,599 bases
Orientation:
Plus strand

Previous Assembly
chr1:154,947,157-154,951,727
(GRCh37/hg19 by Entrez Gene)
Size:
4,571 bases
Orientation:
Plus strand

chr1:154,947,129-154,951,725
(GRCh37/hg19 by Ensembl)
Size:
4,597 bases
Orientation:
Plus strand

Genomic View for CKS1B Gene

Genes around CKS1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKS1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKS1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKS1B Gene

Proteins for CKS1B Gene

  • Protein details for CKS1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61024-CKS1_HUMAN
    Recommended name:
    Cyclin-dependent kinases regulatory subunit 1
    Protein Accession:
    P61024
    Secondary Accessions:
    • P33551

    Protein attributes for CKS1B Gene

    Size:
    79 amino acids
    Molecular mass:
    9660 Da
    Quaternary structure:
    • Forms a homohexamer that can probably bind six kinase subunits.

    Three dimensional structures from OCA and Proteopedia for CKS1B Gene

neXtProt entry for CKS1B Gene

Post-translational modifications for CKS1B Gene

  • Ubiquitination at Lys4
  • Modification sites at PhosphoSitePlus

Other Protein References for CKS1B Gene

Antibodies for research

  • Abcam antibodies for CKS1B
  • Santa Cruz Biotechnology (SCBT) Antibodies for CKS1B

No data available for DME Specific Peptides for CKS1B Gene

Domains & Families for CKS1B Gene

Gene Families for CKS1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CKS1B Gene

Suggested Antigen Peptide Sequences for CKS1B Gene

GenScript: Design optimal peptide antigens:
  • Cyclin-dependent kinases regulatory subunit 1 (CKS1_HUMAN)
  • CDC28 protein kinase regulatory subunit 1B, isoform CRA_a (D3DV79_HUMAN)
  • cDNA, FLJ92030, Homo sapiens CDC28 protein kinase regulatory subunit 1B (CKS1B),mRNA (Q5T178_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61024

UniProtKB/Swiss-Prot:

CKS1_HUMAN :
  • Belongs to the CKS family.
Family:
  • Belongs to the CKS family.
genes like me logo Genes that share domains with CKS1B: view

Function for CKS1B Gene

Molecular function for CKS1B Gene

UniProtKB/Swiss-Prot Function:
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

Phenotypes From GWAS Catalog for CKS1B Gene

Gene Ontology (GO) - Molecular Function for CKS1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 2227411
GO:0016301 kinase activity IEA --
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA --
GO:0019901 protein kinase binding IBA 21873635
GO:0042393 histone binding IBA 21873635
genes like me logo Genes that share ontologies with CKS1B: view
genes like me logo Genes that share phenotypes with CKS1B: view

Animal Models for CKS1B Gene

MGI Knock Outs for CKS1B:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CKS1B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CKS1B Gene

Localization for CKS1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CKS1B gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CKS1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0019005 SCF ubiquitin ligase complex IBA 21873635
genes like me logo Genes that share ontologies with CKS1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CKS1B Gene

Pathways & Interactions for CKS1B Gene

genes like me logo Genes that share pathways with CKS1B: view

Pathways by source for CKS1B Gene

2 KEGG pathways for CKS1B Gene
3 GeneGo (Thomson Reuters) pathways for CKS1B Gene
  • Cell cycle ESR1 regulation of G1/S transition
  • Cell cycle Role of SCF complex in cell cycle regulation
  • Cell cycle_Role of APC in cell cycle regulation

Gene Ontology (GO) - Biological Process for CKS1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007049 cell cycle IEA --
GO:0007346 regulation of mitotic cell cycle IBA 21873635
GO:0008283 cell proliferation IEA --
genes like me logo Genes that share ontologies with CKS1B: view

No data available for SIGNOR curated interactions for CKS1B Gene

Drugs & Compounds for CKS1B Gene

(4) Drugs for CKS1B Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fluoxetine Approved, Vet_approved Pharma Target 290
2,8-bis[oxido(oxo)vanadio]-1,1,1,3,5,5,7,7,9,9,9-undecaoxopentavanadoxane-2,8-diium Experimental Pharma Target 0
genes like me logo Genes that share compounds with CKS1B: view

Transcripts for CKS1B Gene

mRNA/cDNA for CKS1B Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CKS1B

Alternative Splicing Database (ASD) splice patterns (SP) for CKS1B Gene

No ASD Table

Relevant External Links for CKS1B Gene

GeneLoc Exon Structure for
CKS1B

Expression for CKS1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CKS1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CKS1B Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (56.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CKS1B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CKS1B

SOURCE GeneReport for Unigene cluster for CKS1B Gene:

Hs.374378

Evidence on tissue expression from TISSUES for CKS1B Gene

  • Nervous system(4.6)
  • Muscle(4.3)
  • Liver(3.5)
  • Lung(2.8)
  • Blood(2.5)
  • Skin(2.4)
  • Intestine(2.3)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with CKS1B: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CKS1B Gene

Orthologs for CKS1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CKS1B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CKS1B 29 30
  • 100 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia CKS1B 29
  • 96.2 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 95 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia CKS1B 29
  • 94.94 (n)
Mouse
(Mus musculus)
Mammalia Cks1b 29 16 30
  • 93.25 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cks1b 29
  • 92.83 (n)
Oppossum
(Monodelphis domestica)
Mammalia CKS1B 30
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CKS1B 29 30
  • 81.01 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 95 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cks1b 29
  • 79.65 (n)
Str.7452 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.3190 29
Zebrafish
(Danio rerio)
Actinopterygii cks1b 29 30
  • 79.73 (n)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1323 29
Fruit Fly
(Drosophila melanogaster)
Insecta Cks85A 29 30
  • 67.61 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003796 29
  • 66.2 (n)
Worm
(Caenorhabditis elegans)
Secernentea cks-1 29 30
  • 65.8 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKS1 30 32
  • 26 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 43 (a)
OneToMany
Species where no ortholog for CKS1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CKS1B Gene

ENSEMBL:
Gene Tree for CKS1B (if available)
TreeFam:
Gene Tree for CKS1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CKS1B: view image
Alliance of Genome Resources:
Additional Orthologs for CKS1B

Paralogs for CKS1B Gene

Paralogs for CKS1B Gene

(1) SIMAP similar genes for CKS1B Gene using alignment to 5 proteins:

  • CKS1_HUMAN
  • D3DV79_HUMAN
  • Q5T178_HUMAN
  • Q5T179_HUMAN
  • Q9BZU3_HUMAN

Pseudogenes.org Pseudogenes for CKS1B Gene

genes like me logo Genes that share paralogs with CKS1B: view

Variants for CKS1B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CKS1B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CKS1B Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV insertion 20534489
nsv946409 CNV duplication 23825009

Variation tolerance for CKS1B Gene

Residual Variation Intolerance Score: 50.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CKS1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CKS1B
Leiden Open Variation Database (LOVD)
CKS1B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CKS1B Gene

Disorders for CKS1B Gene

MalaCards: The human disease database

(4) MalaCards diseases for CKS1B Gene - From: COP and GCD

Disorder Aliases PubMed IDs
clear cell adenofibroma
  • cystadenofibroma
ceroid lipofuscinosis, neuronal, 2
  • cln2
breast cancer
  • breast cancer, familial
myeloma, multiple
  • multiple myeloma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search CKS1B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CKS1B

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CKS1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CKS1B Gene

Publications for CKS1B Gene

  1. Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. (PMID: 2227411) Richardson HE … Reed SI (Genes & development 1990) 2 3 4 22
  2. Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. (PMID: 8601310) Bourne Y … Tainer JA (Cell 1996) 3 4 22
  3. Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain. (PMID: 7791211) Arvai AS … Tainer JA (Journal of molecular biology 1995) 3 4 22
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  5. Prognostic implication of p27Kip1, Skp2 and Cks1 expression in renal cell carcinoma: a tissue microarray study. (PMID: 18922157) Liu Z … Ding K (Journal of experimental & clinical cancer research : CR 2008) 3 22

Products for CKS1B Gene

Sources for CKS1B Gene