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The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]
CKM (Creatine Kinase, M-Type) is a Protein Coding gene. Diseases associated with CKM include Mcleod Syndrome and Myotonic Dystrophy. Among its related pathways are Abacavir Pathway, Pharmacokinetics/Pharmacodynamics and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and creatine kinase activity. An important paralog of this gene is CKB.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003824 | catalytic activity | IEA | -- |
GO:0004111 | creatine kinase activity | TAS,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 12972258 |
GO:0005524 | ATP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IEA,IBA | 21873635 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of activated PAK-2p34 by proteasome mediated degradation | ||
2 | Metabolism |
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|
3 | Arginine and proline metabolism | ||
4 | Abacavir Pathway, Pharmacokinetics/Pharmacodynamics | ||
5 | AMPK Enzyme Complex Pathway |
AMPK Enzyme Complex Pathway
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|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006600 | creatine metabolic process | TAS | -- |
GO:0016310 | phosphorylation | IEA | -- |
GO:0046314 | phosphocreatine biosynthetic process | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Creatine | Approved, Investigational | Nutra | Target, ligand | 176 | ||
Acyclovir | Approved | Pharma | Enzyme, substrate | 117 | ||
Tenofovir disoproxil | Approved, Investigational | Pharma | Enzyme, substrate, inducer | 0 | ||
(Diaminomethyl-Methyl-Amino)-Acetic Acid | Experimental | Pharma | Target | 0 | ||
D-Arginine | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CKM 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CKM 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CKM 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CKM 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ckm 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ckm 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CKM 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CKM 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | CKM 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ckm 30 |
|
||
MGC75682 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | ckm-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ckmb 31 |
|
OneToMany | |
ckma 30 31 |
|
OneToMany | |||
ckm 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5144 31 32 |
|
ManyToMany | |
Argk 31 32 |
|
ManyToMany | |||
CG4546 31 32 |
|
ManyToMany | |||
CG30274 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | ZC434.8 31 32 |
|
ManyToMany | |
F44G3.2 31 32 |
|
ManyToMany | |||
F46H5.3 31 |
|
ManyToMany | |||
W10C8.5 31 32 |
|
ManyToMany | |||
F32B5.1 31 32 |
|
ManyToMany | |||
F11G11.13 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6164 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
710253 | Conflicting Interpretations: not provided | 45,308,434(-) | C/G | MISSENSE_VARIANT | |
721646 | Benign: not provided | 45,315,606(-) | C/T | INTRON_VARIANT | |
784717 | Likely Benign: not provided | 45,306,752(-) | A/G | STOP_LOST | |
808597 | Uncertain Significance: not provided | 45,315,567(-) | G/C | MISSENSE_VARIANT | |
rs11559024 | - | p.Glu83Gly |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2660204 | CNV | deletion | 23128226 |
nsv1063547 | CNV | gain | 25217958 |
nsv579866 | CNV | gain | 21841781 |
nsv833844 | CNV | loss | 17160897 |
nsv833845 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
mcleod syndrome |
|
|
myotonic dystrophy |
|
|
hemophilia b |
|
|
myocardial infarction |
|
|
acute myocardial infarction |
|