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The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]
CKM (Creatine Kinase, M-Type) is a Protein Coding gene. Diseases associated with CKM include Mcleod Syndrome and Prostate Rhabdomyosarcoma. Among its related pathways are Urea cycle and metabolism of amino groups and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and creatine kinase activity. An important paralog of this gene is CKB.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | IEA | -- |
GO:0004111 | creatine kinase activity | IBA,TAS | 21873635 |
GO:0005515 | protein binding | IPI | 12972258 |
GO:0005524 | ATP binding | IEA | -- |
GO:0016301 | kinase activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IBA,IEA | 21873635 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | CDK-mediated phosphorylation and removal of Cdc6 | ||
2 | Metabolism |
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3 | Arginine and proline metabolism | ||
4 | Abacavir Pathway, Pharmacokinetics/Pharmacodynamics | ||
5 | AMPK Enzyme Complex Pathway |
AMPK Enzyme Complex Pathway
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|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006600 | creatine metabolic process | TAS | -- |
GO:0016310 | phosphorylation | IEA | -- |
GO:0046314 | phosphocreatine biosynthetic process | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Creatine | Approved, Investigational | Nutra | Target, ligand | 160 | ||
Acyclovir | Approved | Pharma | Enzyme, substrate | 113 | ||
Tenofovir disoproxil | Approved, Investigational | Pharma | Enzyme, substrate, inducer | 0 | ||
(Diaminomethyl-Methyl-Amino)-Acetic Acid | Experimental | Pharma | Target | 0 | ||
D-Arginine | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CKM 33 32 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | CKM 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | CKM 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | CKM 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Ckm 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Ckm 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | CKM 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | CKM 32 |
|
||
lizard (Anolis carolinensis) |
Reptilia | CKM 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | ckm 32 |
|
||
MGC75682 32 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | ckm-prov 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | ckmb 33 |
|
OneToMany | |
ckma 33 32 |
|
OneToMany | |||
ckm 32 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | CG5144 33 34 |
|
ManyToMany | |
Argk 33 34 |
|
ManyToMany | |||
CG4546 33 34 |
|
ManyToMany | |||
CG30274 33 |
|
ManyToMany | |||
worm (Caenorhabditis elegans) |
Secernentea | ZC434.8 33 34 |
|
ManyToMany | |
F44G3.2 33 34 |
|
ManyToMany | |||
F46H5.3 33 |
|
ManyToMany | |||
W10C8.5 33 34 |
|
ManyToMany | |||
F32B5.1 33 34 |
|
ManyToMany | |||
F11G11.13 33 |
|
ManyToMany | |||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6164 33 |
|
ManyToMany | |
-- 33 |
|
ManyToMany |
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000102560 | -- | 45,320,135(-) | G/A | intron_variant | |
rs1000229767 | -- | 45,311,880(-) | G/A | coding_sequence_variant, synonymous_variant | |
rs1000561040 | -- | 45,320,012(-) | A/T | intron_variant | |
rs1000604221 | -- | 45,323,978(-) | T/A/C | upstream_transcript_variant | |
rs1000910743 | -- | 45,316,338(-) | /T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2660204 | CNV | deletion | 23128226 |
nsv1063547 | CNV | gain | 25217958 |
nsv579866 | CNV | gain | 21841781 |
nsv833844 | CNV | loss | 17160897 |
nsv833845 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
mcleod syndrome |
|
|
prostate rhabdomyosarcoma |
|
|
dressler's syndrome |
|
|
myotonic dystrophy |
|
|
prostate sarcoma |
|
|