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Aliases for CKLF Gene

Aliases for CKLF Gene

  • Chemokine Like Factor 2 3 5
  • Chemokine-Like Factor 1 2 3
  • CKLF1 3 4
  • C32 3 4
  • Transmembrane Proteolipid 3
  • Chemokine-Like Factor 2 3
  • Chemokine-Like Factor 3 3
  • Chemokine-Like Factor 4 3
  • Chemokine-Like Factor 3
  • HSPC224 3
  • CKLF2 3
  • CKLF3 3
  • CKLF4 3
  • UCK-1 3

External Ids for CKLF Gene

Previous HGNC Symbols for CKLF Gene

  • CKLF1

Previous GeneCards Identifiers for CKLF Gene

  • GC16P066964
  • GC16P066321
  • GC16P066362
  • GC16P065143
  • GC16P066586
  • GC16P052462

Summaries for CKLF Gene

Entrez Gene Summary for CKLF Gene

  • The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011]

GeneCards Summary for CKLF Gene

CKLF (Chemokine Like Factor) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CKLF-CMTM1.

UniProtKB/Swiss-Prot for CKLF Gene

  • May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.

  • Isoform 1: has chemotactic response in monocytes, neutrophils and lymphocytes (PubMed:11415443). Binds CCR4 (PubMed:16137713).

Gene Wiki entry for CKLF Gene

Additional gene information for CKLF Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKLF Gene

Genomics for CKLF Gene

GeneHancer (GH) Regulatory Elements for CKLF Gene

Promoters and enhancers for CKLF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I066547 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -1.5 -1512 6.6 MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF416 ZNF143 SP3 NFYC TK2 CKLF CKLF-CMTM1 ENSG00000261519 ENSG00000275745 PIR51465 PIR54425 NAE1 ZDHHC1 BEAN1
GH16I066515 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 29 -31.3 -31339 12.4 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 IRF4 TK2 CKLF ENSG00000260465 ZDHHC1 NAE1 BEAN1 CKLF-CMTM1 E2F4 CMTM2 PLEKHG4
GH16I066502 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -49.8 -49799 1.2 ELF3 RAD21 RARA ETS1 YY1 ZNF366 ATF7 THAP11 RXRA CEBPB TK2 E2F4 CKLF CKLF-CMTM1 ENSG00000260465 CES3 ENSG00000260755 ENSG00000260851 GC16P066491
GH16I066510 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.2 -40.4 -40396 3.8 PKNOX1 FOXA2 ARID4B SIN3A ETS1 TCF12 ELK1 ATF7 FOS RXRA GC16M066512 PIR49300 PIR55233 BEAN1 TK2 BEAN1-AS1 CKLF-CMTM1 CKLF CMTM2 CES4A
GH16I066507 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.9 -44.0 -44031 1.5 PKNOX1 JUN MAX EBF1 BATF RAD21 RFX5 GATA3 SMC3 RCOR1 PIR59655 ENSG00000260755 BEAN1 TK2 CKLF-CMTM1 CKLF ENSG00000260851 GC16P066491
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CKLF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CKLF gene promoter:

Genomic Locations for CKLF Gene

Genomic Locations for CKLF Gene
chr16:66,552,563-66,566,287
(GRCh38/hg38)
Size:
13,725 bases
Orientation:
Plus strand
chr16:66,586,466-66,600,190
(GRCh37/hg19)

Genomic View for CKLF Gene

Genes around CKLF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKLF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKLF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKLF Gene

Proteins for CKLF Gene

  • Protein details for CKLF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBR5-CKLF_HUMAN
    Recommended name:
    Chemokine-like factor
    Protein Accession:
    Q9UBR5
    Secondary Accessions:
    • C9JE38
    • Q9UHM7
    • Q9UHN8
    • Q9UI41

    Protein attributes for CKLF Gene

    Size:
    152 amino acids
    Molecular mass:
    17170 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CKLF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CKLF Gene

Post-translational modifications for CKLF Gene

  • Ubiquitination at posLast=77 and Lys131
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CKLF Gene

Domains & Families for CKLF Gene

Gene Families for CKLF Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CKLF Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CKLF Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBR5

UniProtKB/Swiss-Prot:

CKLF_HUMAN :
  • Belongs to the chemokine-like factor family.
Family:
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CKLF: view

Function for CKLF Gene

Molecular function for CKLF Gene

UniProtKB/Swiss-Prot Function:
May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.
UniProtKB/Swiss-Prot Function:
Isoform 1: has chemotactic response in monocytes, neutrophils and lymphocytes (PubMed:11415443). Binds CCR4 (PubMed:16137713).

Phenotypes From GWAS Catalog for CKLF Gene

Gene Ontology (GO) - Molecular Function for CKLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IDA 11415443
genes like me logo Genes that share ontologies with CKLF: view

Phenotypes for CKLF Gene

genes like me logo Genes that share phenotypes with CKLF: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CKLF

miRNA for CKLF Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CKLF Gene

Localization for CKLF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKLF Gene

Isoform 1: Secreted.
Isoform 2: Membrane; Multi-pass membrane protein.
Isoform 4: Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CKLF gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CKLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,IDA 11415443
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IDA,IEA 11415443
genes like me logo Genes that share ontologies with CKLF: view

Pathways & Interactions for CKLF Gene

No Data Available

Interacting Proteins for CKLF Gene

Gene Ontology (GO) - Biological Process for CKLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0008283 cell proliferation IDA 11415443
GO:0010469 regulation of receptor activity IEA --
GO:0030593 neutrophil chemotaxis IDA 11415443
GO:0030595 leukocyte chemotaxis IEA --
genes like me logo Genes that share ontologies with CKLF: view

No data available for Pathways by source and SIGNOR curated interactions for CKLF Gene

Drugs & Compounds for CKLF Gene

(1) Additional Compounds for CKLF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CKLF: view

Transcripts for CKLF Gene

Unigene Clusters for CKLF Gene

Chemokine-like factor:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CKLF Gene

No ASD Table

Relevant External Links for CKLF Gene

GeneLoc Exon Structure for
CKLF
ECgene alternative splicing isoforms for
CKLF

Expression for CKLF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CKLF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CKLF Gene

This gene is overexpressed in Whole Blood (x15.0).

Protein differential expression in normal tissues from HIPED for CKLF Gene

This gene is overexpressed in Heart (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CKLF Gene



Protein tissue co-expression partners for CKLF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CKLF Gene:

CKLF

SOURCE GeneReport for Unigene cluster for CKLF Gene:

Hs.15159

mRNA Expression by UniProt/SwissProt for CKLF Gene:

Q9UBR5-CKLF_HUMAN
Tissue specificity: Isoform 1, isoform 2, isoform 3 and isoform 4 have highest expression levels in adult spleen, lung, testis, ovary, peripheral blood leukocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart. Lower expression levels in adult skeletal muscle, liver, thymus colon, prostate and fetal spleen and liver.

Evidence on tissue expression from TISSUES for CKLF Gene

  • Blood(4.5)
genes like me logo Genes that share expression patterns with CKLF: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CKLF Gene

Orthologs for CKLF Gene

This gene was present in the common ancestor of mammals.

Orthologs for CKLF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CKLF 33
  • 99.12 (n)
CMTM1 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CKLF 33 34
  • 83.78 (n)
mouse
(Mus musculus)
Mammalia Cklf 33 16 34
  • 74.38 (n)
cow
(Bos Taurus)
Mammalia CKLF 34
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cklf 33
  • 72.89 (n)
Species where no ortholog for CKLF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CKLF Gene

ENSEMBL:
Gene Tree for CKLF (if available)
TreeFam:
Gene Tree for CKLF (if available)

Paralogs for CKLF Gene

Paralogs for CKLF Gene

(2) SIMAP similar genes for CKLF Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CKLF: view

Variants for CKLF Gene

Sequence variations from dbSNP and Humsavar for CKLF Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000375684 -- 66,560,839(+) T/A intron_variant
rs1000388020 -- 66,552,895(+) C/T intron_variant
rs1000665043 -- 66,562,398(+) A/G intron_variant
rs1000685295 -- 66,560,529(+) G/A intron_variant
rs1000778372 -- 66,554,411(+) T/G intron_variant

Variation tolerance for CKLF Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CKLF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CKLF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CKLF Gene

Disorders for CKLF Gene

Additional Disease Information for CKLF

No disorders were found for CKLF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CKLF Gene

Publications for CKLF Gene

  1. Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity. (PMID: 11415443) Han W … Ma D (The Biochemical journal 2001) 2 3 4 22 58
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  3. [The expression of chemokine-like factor 1 in human atherosclerotic plaques]. (PMID: 20137403) Jiao Y … Zhang XM (Zhonghua wai ke za zhi [Chinese journal of surgery] 2009) 3 22 58
  4. Two C-terminal peptides of human CKLF1 interact with the chemokine receptor CCR4. (PMID: 18069042) Wang Y … Ma D (The international journal of biochemistry & cell biology 2008) 3 22 58
  5. Chemokine-like factor expression in the idiopathic inflammatory myopathies. (PMID: 18294340) Chowdhury MH … Yamaguchi S (Acta neurologica Scandinavica 2008) 3 22 58

Products for CKLF Gene

Sources for CKLF Gene

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