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Aliases for CKB Gene

Aliases for CKB Gene

  • Creatine Kinase B 2 3 5
  • Creatine Phosphokinase B-Type 3 4
  • Creatine Kinase Brain-Type 2 3
  • Creatine Kinase B Chain 3 4
  • Brain Creatine Kinase 3 4
  • CPK-B 3 4
  • CKBB 3 4
  • B-CK 3 4
  • Epididymis Secretory Protein Li 29 3
  • Epididymis Luminal Protein 211 3
  • Creatine Kinase B-Type 3
  • Creatine Kinase, Brain 2
  • Creatine Kinase Brain 3
  • EC 4
  • HEL-S-29 3
  • HEL-211 3
  • BCK 3

External Ids for CKB Gene

Previous HGNC Symbols for CKB Gene

  • CKBB

Previous GeneCards Identifiers for CKB Gene

  • GC14M101377
  • GC14M097801
  • GC14M101976
  • GC14M103055
  • GC14M103986

Summaries for CKB Gene

Entrez Gene Summary for CKB Gene

  • The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for CKB Gene

CKB (Creatine Kinase B) is a Protein Coding gene. Diseases associated with CKB include Prostate Rhabdomyosarcoma and Dressler's Syndrome. Among its related pathways are Metabolism and Arginine and proline metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is CKM.

UniProtKB/Swiss-Prot for CKB Gene

  • Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Additional gene information for CKB Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CKB Gene

Genomics for CKB Gene

GeneHancer (GH) Regulatory Elements for CKB Gene

Promoters and enhancers for CKB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J103517 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 674.1 +2.4 2443 6.4 HDGF ARNT ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF213 CKB GC14M103376 XRCC3 MARK3 BAG5 RPL23AP11 CDC42BPB RNU7-160P ENSG00000269940 ENSG00000260285
GH14J103523 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 -4.0 -3994 6.4 HDGF FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 TRMT61A CKB ENSG00000260285 MARK3 KLC1 CDC42BPB ZFYVE21 APOPT1 GC14P103445
GH14J103560 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.3 -39.6 -39562 3.6 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 E2F8 ZNF207 ZNF143 APOPT1 KLC1 BAG5 ENSG00000256500 CKB XRCC3 RCOR1 ENSG00000258851 GC14P103445
GH14J103384 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 22.6 +137.0 137011 3.7 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 MARK3 CKB BAG5 ZFYVE21 KLC1 ENSG00000246451 RPL10AP1 GC14M103376
GH14J103332 Promoter/Enhancer 2.7 UCNEbase EPDnew Ensembl ENCODE dbSUPER 15.7 +188.8 188753 4.7 CLOCK ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1 ENSG00000259775 EIF5 BAG5 XRCC3 CKB KLC1 MARK3 ENSG00000260285 ZFYVE21 PIR56134
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CKB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CKB gene promoter:
  • AP-2alphaA
  • AP-2alpha isoform 4
  • AP-2alpha isoform 3
  • AP-2alpha isoform 2
  • AP-2alpha
  • SRY
  • Max1
  • USF-1
  • USF-1:USF-2
  • USF1

Genomic Locations for CKB Gene

Genomic Locations for CKB Gene
3,454 bases
Minus strand
3,453 bases
Minus strand

Genomic View for CKB Gene

Genes around CKB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKB Gene

Proteins for CKB Gene

  • Protein details for CKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Creatine kinase B-type
    Protein Accession:
    Secondary Accessions:
    • A8K236
    • B2R5R4
    • Q2LE07
    • Q6FG40
    • Q9UC66

    Protein attributes for CKB Gene

    381 amino acids
    Molecular mass:
    42644 Da
    Quaternary structure:
    • Dimer of identical or non-identical chains, which can be either B (brain type) or M (muscle type). With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.

    Three dimensional structures from OCA and Proteopedia for CKB Gene

neXtProt entry for CKB Gene

Post-translational modifications for CKB Gene

  • Ubiquitination at Lys313, posLast=307307, Lys304, Lys298, Lys265, posLast=242242, posLast=223223, and Lys11
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CKB Gene

Domains & Families for CKB Gene

Gene Families for CKB Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CKB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ATP:guanido phosphotransferase family.
  • Belongs to the ATP:guanido phosphotransferase family.
genes like me logo Genes that share domains with CKB: view

Function for CKB Gene

Molecular function for CKB Gene

UniProtKB/Swiss-Prot Function:
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + creatine = ADP + phosphocreatine.
GENATLAS Biochemistry:
creatine kinase,brain

Enzyme Numbers (IUBMB) for CKB Gene

Phenotypes From GWAS Catalog for CKB Gene

Gene Ontology (GO) - Molecular Function for CKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004111 creatine kinase activity TAS,ISS --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with CKB: view
genes like me logo Genes that share phenotypes with CKB: view

Animal Models for CKB Gene

MGI Knock Outs for CKB:
  • Ckb Ckb<tm1Bew>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CKB

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CKB Gene

Localization for CKB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKB Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CKB gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
mitochondrion 3
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with CKB: view

Pathways & Interactions for CKB Gene

genes like me logo Genes that share pathways with CKB: view

Pathways by source for CKB Gene

Gene Ontology (GO) - Biological Process for CKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006600 creatine metabolic process TAS --
GO:0007420 brain development IEA --
GO:0016310 phosphorylation IEA --
GO:0021549 cerebellum development IEA --
GO:0021762 substantia nigra development HEP 22926577
genes like me logo Genes that share ontologies with CKB: view

No data available for SIGNOR curated interactions for CKB Gene

Drugs & Compounds for CKB Gene

(20) Drugs for CKB Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Creatine Approved, Investigational Nutra Target, ligand 139
Magnesium gluconate Approved, Investigational Pharma Enzyme, substrate, inducer 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
Phosphocreatine Nutra Target, ligand 10

(11) Additional Compounds for CKB Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with CKB: view

Transcripts for CKB Gene

Unigene Clusters for CKB Gene

Creatine kinase, brain:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CKB

Alternative Splicing Database (ASD) splice patterns (SP) for CKB Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: -
SP5: - -
SP6: -
SP7: - - -

Relevant External Links for CKB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CKB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CKB Gene

Protein differential expression in normal tissues from HIPED for CKB Gene

This gene is overexpressed in Retina (13.0), Brain (6.7), and Cardia (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CKB Gene

Protein tissue co-expression partners for CKB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CKB Gene:


SOURCE GeneReport for Unigene cluster for CKB Gene:


Evidence on tissue expression from TISSUES for CKB Gene

  • Nervous system(5)
  • Eye(4.9)
  • Lung(4.8)
  • Intestine(4.4)
  • Heart(4.1)
  • Stomach(4)
  • Muscle(3.9)
  • Kidney(3)
  • Pancreas(2.8)
genes like me logo Genes that share expression patterns with CKB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CKB Gene

Orthologs for CKB Gene

This gene was present in the common ancestor of animals.

Orthologs for CKB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CKB 34 33
  • 99.74 (n)
(Canis familiaris)
Mammalia CKB 34 33
  • 94.23 (n)
-- 34
  • 84 (a)
-- 34
  • 81 (a)
-- 34
  • 76 (a)
(Bos Taurus)
Mammalia CKB 34 33
  • 93.18 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 92 (a)
-- 34
  • 88 (a)
(Rattus norvegicus)
Mammalia Ckb 33
  • 91.34 (n)
(Mus musculus)
Mammalia Ckb 16 34 33
  • 90.46 (n)
(Monodelphis domestica)
Mammalia CKB 34
  • 38 (a)
(Gallus gallus)
Aves CKB 34 33
  • 79.44 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 82 (a)
-- 34
  • 79 (a)
-- 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ckb 33
  • 74.1 (n)
(Danio rerio)
Actinopterygii ckba 34
  • 84 (a)
ckbb 34 33
  • 77.78 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1737 33
fruit fly
(Drosophila melanogaster)
Insecta CG5144 34 35
  • 35 (a)
CG4546 34 35
  • 29 (a)
Argk 34 35
  • 28 (a)
CG30274 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea ZC434.8 34 35
  • 40 (a)
F44G3.2 34 35
  • 38 (a)
F46H5.3 34
  • 37 (a)
W10C8.5 34 35
  • 36 (a)
F11G11.13 34
  • 33 (a)
F32B5.1 34 35
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6164 34
  • 69 (a)
-- 34
  • 66 (a)
Cin.2638 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2638 33
Species where no ortholog for CKB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CKB Gene

Gene Tree for CKB (if available)
Gene Tree for CKB (if available)
Evolutionary constrained regions (ECRs) for CKB: view image

Paralogs for CKB Gene

Paralogs for CKB Gene

(4) SIMAP similar genes for CKB Gene using alignment to 7 proteins:

  • G3V2I1_HUMAN
  • G3V461_HUMAN
  • G3V4N7_HUMAN
  • H0YJK0_HUMAN Pseudogenes for CKB Gene

genes like me logo Genes that share paralogs with CKB: view

Variants for CKB Gene

Sequence variations from dbSNP and Humsavar for CKB Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000928715 -- 103,524,166(-) A/G upstream_transcript_variant
rs1001043594 -- 103,524,228(-) C/G upstream_transcript_variant
rs1001144563 -- 103,523,937(-) G/A upstream_transcript_variant
rs1001962775 -- 103,523,472(-) G/A upstream_transcript_variant
rs1002224019 -- 103,521,710(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CKB Gene

Variant ID Type Subtype PubMed ID
dgv3938n54 CNV loss 21841781
dgv3939n54 CNV loss 21841781
dgv3940n54 CNV gain 21841781
dgv3941n54 CNV gain+loss 21841781
dgv3942n54 CNV gain 21841781
dgv3943n54 CNV gain 21841781
dgv3944n54 CNV loss 21841781
dgv3945n54 CNV gain+loss 21841781
dgv3946n54 CNV loss 21841781
esv29714 CNV loss 19812545
nsv1044967 CNV gain 25217958
nsv1054574 CNV loss 25217958
nsv565994 CNV gain 21841781
nsv565997 CNV loss 21841781
nsv565998 CNV loss 21841781
nsv565999 CNV gain+loss 21841781
nsv566003 CNV gain+loss 21841781
nsv566004 CNV gain 21841781
nsv566019 CNV gain 21841781
nsv827068 CNV loss 20364138
nsv832883 CNV loss 17160897
nsv952259 CNV deletion 24416366

Variation tolerance for CKB Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CKB Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKB Gene

Disorders for CKB Gene

MalaCards: The human disease database

(12) MalaCards diseases for CKB Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate rhabdomyosarcoma
  • rhabdomyosarcoma of the prostate
dressler's syndrome
  • dressler syndrome
macular telangiectasia type 2
  • idiopathic juxtafoveal retinal telangiectasia
neonatal hypoxic and ischemic brain injury
  • hie
prostate sarcoma
  • sarcoma of the prostate
- elite association - COSMIC cancer census association via MalaCards
Search CKB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CKB

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CKB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CKB Gene

Publications for CKB Gene

  1. Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation. (PMID: 17148442) Debrincat MA … Hilton DJ (The Journal of biological chemistry 2007) 3 22 25 58
  2. Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. (PMID: 16384981) Haines JL … Pericak-Vance MA (Investigative ophthalmology & visual science 2006) 3 22 44 58
  3. Creatine kinase B is necessary to limit myoblast fusion during myogenesis. (PMID: 25810257) Simionescu-Bankston A … Pavlath GK (American journal of physiology. Cell physiology 2015) 2 3 58
  4. Reduced creatine kinase B activity in multiple sclerosis normal appearing white matter. (PMID: 20520825) Steen C … De Keyser J (PloS one 2010) 3 22 58
  5. Structural studies of human brain-type creatine kinase complexed with the ADP-Mg2+-NO3- -creatine transition-state analogue complex. (PMID: 18977227) Bong SM … Hwang KY (FEBS letters 2008) 3 4 58

Products for CKB Gene

Sources for CKB Gene

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