Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
CKAP5 (Cytoskeleton Associated Protein 5) is a Protein Coding gene. Diseases associated with CKAP5 include Tylosis With Esophageal Cancer and Macular Degeneration, Age-Related, 6. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. Gene Ontology (GO) annotations related to this gene include binding and endonuclease activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 11903063 |
GO:0008017 | microtubule binding | IDA | 10770946 |
GO:0043021 | ribonucleoprotein complex binding | IDA | 15703215 |
GO:0045296 | cadherin binding | HDA | 25468996 |
GO:0061863 | microtubule plus end polymerase | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000775 | chromosome, centromeric region | IEA | -- |
GO:0000776 | kinetochore | IBA,IDA | 25596274 |
GO:0000777 | condensed chromosome kinetochore | IEA | -- |
GO:0000922 | spindle pole | IBA,IDA | 21646404 |
GO:0000930 | colocalizes_with gamma-tubulin complex | IDA | 14718566 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of PLK1 Activity at G2/M Transition |
.50
|
|
2 | Cell Cycle, Mitotic |
.83
|
.60
|
3 | Mitotic Metaphase and Anaphase |
.94
|
|
4 | Mitotic Prometaphase | ||
5 | Organelle biogenesis and maintenance |
.56
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
GO:0007019 | microtubule depolymerization | TAS | 26323690 |
GO:0007049 | cell cycle | IEA | -- |
GO:0007051 | spindle organization | IMP | 14718566 |
GO:0007052 | mitotic spindle organization | IBA | 21873635 |
Compound | Action | Cas Number |
---|---|---|
10-DAB (10-Deacetylbaccatin) | Precursor of antitumor compound Palitaxel and Docetaxel | 32981-86-5 |
ABT-751 (E7010) | Inhibitor of microtubule polymerization,antimitotic | 141430-65-1 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: |
ExUns: | 24b | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37 | ^ | 38 | ^ | 39 | ^ | 40 | ^ | 41 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||
SP8: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CKAP5 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CKAP5 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CKAP5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CKAP5 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ckap5 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ckap5 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | CKAP5 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CKAP5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CKAP5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ckap5 30 |
|
||
Str.3305 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | LOC398198 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ckap5 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | msps 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011162 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | T08D2.8 31 |
|
OneToMany | |
zyg-9 31 |
|
OneToMany | |||
F54A3.2 31 |
|
OneToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STU2 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | MOR1 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0816400 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2441 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1565739639 | Uncertain Significance: not provided | 46,795,619(-) | G/A | MISSENSE_VARIANT | |
rs193921076 | Uncertain Significance: Malignant tumor of prostate | 46,809,784(-) | T/C | MISSENSE_VARIANT | |
rs11038988 | - | p.Tyr785Cys |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3547703 | CNV | deletion | 23714750 |
nsv1122612 | CNV | deletion | 24896259 |
nsv1138017 | CNV | deletion | 24896259 |
nsv472167 | CNV | novel sequence insertion | 20440878 |
Disorder | Aliases | PubMed IDs |
---|---|---|
tylosis with esophageal cancer |
|
|
macular degeneration, age-related, 6 |
|
|
macular degeneration, age-related, 4 |
|
|
epidermolysis bullosa, junctional, non-herlitz type |
|
|
mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes |
|
|