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This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential... See more...
Aliases for CKAP5 Gene
Aliases for CKAP5 Gene
External Ids for CKAP5 Gene
- HGNC: 28959
- Entrez Gene: 9793
- Ensembl: ENSG00000175216
- OMIM: 611142
- UniProtKB: Q14008
Previous GeneCards Identifiers for CKAP5 Gene
- GC11M046722
- GC11M046470
- GC11M046815
- GC11M048068
- GC11M048794
- GC11M049892
- GC11M047086
- GC11M047930
- GC11M055797
- GC11M056010
- GC11M056161
- GC11M059679
- GC11M050784
- GC11M051579
- GC11M052241
- GC11M052901
- GC11M053569
- GC11M054235
- GC11M054901
- GC11M055599
Summaries for CKAP5 Gene
-
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
GeneCards Summary for CKAP5 Gene
CKAP5 (Cytoskeleton Associated Protein 5) is a Protein Coding gene. Diseases associated with CKAP5 include Tylosis With Esophageal Cancer and Macular Degeneration, Age-Related, 6. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. Gene Ontology (GO) annotations related to this gene include binding and endonuclease activity.
UniProtKB/Swiss-Prot Summary for CKAP5 Gene
-
Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448).
Additional gene information for CKAP5 Gene
- HGNC(28959)
- Entrez Gene(9793)
- Ensembl(ENSG00000175216)
- OMIM(611142)
- UniProtKB(Q14008)
- Open Targets Platform(ENSG00000175216)
- Search for CKAP5 at DataMed
- Search for CKAP5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CKAP5 Gene
Genomics for CKAP5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CKAP5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CKAP5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CKAP5
- Top Transcription factor binding sites by QIAGEN in the CKAP5 gene promoter:
-
- AML1a
- CUTL1
- E2F
- E2F-1
- Egr-2
- HEN1
- Lmo2
- NF-1
- Pax-4a
- Zic3
Genomic Locations for CKAP5 Gene
Genomic Locations for CKAP5 Gene
- chr11:46,743,048-46,846,308
- (GRCh38/hg38)
- Size:
- 103,261 bases
- Orientation:
- Minus strand
- chr11:46,764,598-46,867,847
- (GRCh37/hg19)
- Size:
- 103,250 bases
- Orientation:
- Minus strand
Genomic View for CKAP5 Gene
Genes around CKAP5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by HGNC
- 11p11.2 by Entrez Gene
- 11p11.2 by Ensembl
CKAP5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CKAP5 Gene
Proteins for CKAP5 Gene
-
Protein details for CKAP5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14008-CKAP5_HUMAN
- Recommended name:
- Cytoskeleton-associated protein 5
- Protein Accession:
- Q14008
- Q05D70
- Q0VAX7
- Q0VAX8
- Q14668
- Q2TA89
- Q6NSH4
Protein attributes for CKAP5 Gene
- Size:
- 2032 amino acids
- Molecular mass:
- 225495 Da
- Quaternary structure:
-
- Interacts with TACC1 (PubMed:11903063). Interacts with SLAIN2 and SLAIN1 (PubMed:21646404). Interacts with HNRNPA2B1 (PubMed:15703215). Interacts with TACC3 independently of clathrin (PubMed:25596274). Interacts with TACC3 and clathrin forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges (PubMed:21297582, PubMed:23532825). Interacts with NDC80; indicative for an association with the NDC80 complex (PubMed:27156448).
- SequenceCaution:
-
- Sequence=AAH17856.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH70136.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI11044.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI20871.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA07892.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for CKAP5 Gene
Selected DME Specific Peptides for CKAP5 Gene
- Q14008:
-
- KIILLKP
- KKIGSKE
Post-translational modifications for CKAP5 Gene
Other Protein References for CKAP5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences CKAP5 / ch-TOG Antibody
-
Custom Antibody ServicesOriGene Antibodies for CKAP5
- Novus Biologicals Antibodies for CKAP5
-
Abcam antibodies for CKAP5
- Invitrogen Antibodies for CKAP5 (AFLGC-CKAP5)
-
Biorbyt antibodies for CKAP5
-
Boster Bio Antibodies for CKAP5
-
Santa Cruz Biotechnology (SCBT) Antibodies for CKAP5
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CKAP5
- Origene Custom Protein Services for CKAP5
- Novus Biologicals proteins for CKAP5
Domains & Families for CKAP5 Gene
Gene Families for CKAP5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CKAP5 Gene
- InterPro:
- Blocks:
-
- HEAT repeat
- ProtoNet:
Suggested Antigen Peptide Sequences for CKAP5 Gene
- GenScript: Design optimal peptide antigens:
-
- Colonic and hepatic tumor over-expressed gene protein (CKAP5_HUMAN)
- CKAP5 protein (Q8IYN5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q14008UniProtKB/Swiss-Prot:
CKAP5_HUMAN :- The TOG (tumor overexpressed gene) domains are arranged in a N-terminal pentameric array with each domain composed of six (for the most part non-canonical) HEAT repeats forming a oblong paddle-like structure. Intra-HEAT loops are positioned along a face of the TOG domain and bind to a single alpha/beta-tubulin heterodimer. The TOG domains in the array seem to be structurally and functionally polarized. Differential functions may range from microtubule (MT) lattice binding and/or free tubulin heterodimer binding to potentiating stable incorporation of tubulin into the MT lattice.
- Belongs to the TOG/XMAP215 family.
- Domain:
-
- The TOG (tumor overexpressed gene) domains are arranged in a N-terminal pentameric array with each domain composed of six (for the most part non-canonical) HEAT repeats forming a oblong paddle-like structure. Intra-HEAT loops are positioned along a face of the TOG domain and bind to a single alpha/beta-tubulin heterodimer. The TOG domains in the array seem to be structurally and functionally polarized. Differential functions may range from microtubule (MT) lattice binding and/or free tubulin heterodimer binding to potentiating stable incorporation of tubulin into the MT lattice.
- Family:
-
- Belongs to the TOG/XMAP215 family.
Function for CKAP5 Gene
Molecular function for CKAP5 Gene
- UniProtKB/Swiss-Prot Function:
- Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448).
Enzyme Numbers (IUBMB) for CKAP5 Gene
Phenotypes From GWAS Catalog for CKAP5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11903063 |
| GO:0008017 | microtubule binding | IDA | 10770946 |
| GO:0043021 | ribonucleoprotein complex binding | IDA | 15703215 |
| GO:0045296 | cadherin binding | HDA | 25468996 |
| GO:0061863 | microtubule plus end polymerase | IBA | 21873635 |
Phenotypes for CKAP5 Gene
- MGI mutant phenotypes for CKAP5:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for CKAP5:
-
- no effect
- Decreased viability
- Decreased viability of wild-type and TP53 knockout cells
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with Ras
- Increased gamma-H2AX phosphorylation
- Decreased shRNA abundance
- Increased ionizing radiation sensitivity
- Decreased Hepatitis C virus replication
- FOXO1 nuclear localization
- Decreased cell number
- Inconclusive
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in ovarian lineage
- HIV Rev nuclear localization
- Cell division defect
- Decreased homologous recombination repair frequency
- Polylobed nuclei
- Mitotic spindle defects
- Increased number of mitotic cells
- Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Downregulation of NFkappaB pathway
- Multipolar spindles
- Decreased cell number, increased G2M DNA content, increased 8N DNA content
- Decreased viability with neratinib
- Many micronuclei (grape)
- Increased mitotic delay (prometaphase or metaphase alignment problems, MAP), decreased viability (cell death)
- Increased mitotic delay (prometaphase or metaphase alignment problems, MAP), many micronuclei (grape), decreased viability (cell death)
- Acentrosomal spindle poles
Animal Models for CKAP5 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CKAP5 - Select products 50% OFF >
- * CKAP5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CKAP5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CKAP5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CKAP5
miRNA for CKAP5 Gene
- miRTarBase miRNAs that target CKAP5
-
- hsa-miR-155-5p (MIRT006116)
- mmu-miR-340-5p (MIRT010387)
- hsa-miR-130b-3p (MIRT020260)
- hsa-miR-34a-5p (MIRT025470)
- hsa-miR-103a-3p (MIRT027176)
- hsa-miR-21-5p (MIRT030873)
- hsa-miR-18a-5p (MIRT031322)
- hsa-miR-16-5p (MIRT031832)
- hsa-miR-484 (MIRT042131)
- hsa-miR-186-5p (MIRT044934)
- hsa-miR-15b-5p (MIRT046473)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CKAP5
- Browse OriGene Inhibitory RNA Products For CKAP5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CKAP5
Clone Products
- Applied Biological Materials (abm): Clones for CKAP5 - Select products 50% OFF >
- * CKAP5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CKAP5
- Addgene plasmids for CKAP5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CKAP5
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CKAP5 Gene
Localization for CKAP5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CKAP5 Gene
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Detected on centrosomes and kinetochores during interphase and mitosis independently from TACC3 and clathrin. Located to spindle poles and microtubules during mitosis. In complex with TACC3 localized to microtubule plus-ends in mitosis and interphase. In complex with TACC3 and clathrin localized to inter-microtubule bridges in mitotic spindles. Accumulation sites at microtubule plus ends protruded approximately 100 nm from MAPRE1/EB1 sites in interphase cells. {ECO:0000269 PubMed:21646404, ECO:0000269 PubMed:23251535, ECO:0000269 PubMed:25596274}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| extracellular | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Centrosome (3)
- Nucleoli (1)
- Plasma membrane (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000776 | kinetochore | IBA,IDA | 25596274 |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0000922 | spindle pole | IBA,IDA | 21646404 |
| GO:0000930 | colocalizes_with gamma-tubulin complex | IDA | 14718566 |
Pathways & Interactions for CKAP5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of PLK1 Activity at G2/M Transition |
.50
|
|
| 2 | Cell Cycle, Mitotic |
.83
|
.60
|
| 3 | Mitotic Metaphase and Anaphase |
.94
|
|
| 4 | Mitotic Prometaphase | ||
| 5 | Organelle biogenesis and maintenance |
.56
|
|
Pathways by source for CKAP5 Gene
1 BioSystems pathway for CKAP5 Gene
23 Reactome pathways for CKAP5 Gene
2 Cell Signaling Technology pathways for CKAP5 Gene
Interacting Proteins for CKAP5 Gene
Selected Interacting proteins:
Q14008-CKAP5_HUMAN
ENSP00000432768
for CKAP5 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CKAP5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
| GO:0007019 | microtubule depolymerization | TAS | 26323690 |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007051 | spindle organization | IMP | 14718566 |
| GO:0007052 | mitotic spindle organization | IBA | 21873635 |
No data available for SIGNOR curated interactions for CKAP5 Gene
Drugs & Compounds for CKAP5 Gene
(2) ApexBio Compounds for CKAP5 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 10-DAB (10-Deacetylbaccatin) | Precursor of antitumor compound Palitaxel and Docetaxel | 32981-86-5 |
| ABT-751 (E7010) | Inhibitor of microtubule polymerization,antimitotic | 141430-65-1 |
Transcripts for CKAP5 Gene
mRNA/cDNA for CKAP5 Gene
- 2 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000529230 7172 nts (view in UCSC)
- ENST00000354558 6428 nts (view in UCSC)
- ENST00000533413 3084 nts (view in UCSC)
- ENST00000525896 832 nts (view in UCSC)
- ENST00000527333 498 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CKAP5 - Select products 50% OFF >
- * CKAP5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CKAP5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CKAP5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CKAP5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CKAP5
- Browse OriGene Inhibitory RNA Products For CKAP5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CKAP5
Clone Products
- Applied Biological Materials (abm): Clones for CKAP5 - Select products 50% OFF >
- * CKAP5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CKAP5
- Addgene plasmids for CKAP5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CKAP5
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 24b | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37 | ^ | 38 | ^ | 39 | ^ | 40 | ^ | 41 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||
| SP8: | - |
Relevant External Links for CKAP5 Gene
- GeneLoc Exon Structure for
- CKAP5
Expression for CKAP5 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (15.7) and Fetal Brain (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CKAP5 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CKAP5
SOURCE GeneReport for Unigene cluster for CKAP5 Gene:
Hs.201253mRNA Expression by UniProt/SwissProt for CKAP5 Gene:
Q14008-CKAP5_HUMAN
Tissue specificity:
Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas. Expression is elevated in the brain; highly expressed in the Purkinje cell bodies of the cerebellum.
Evidence on tissue expression from TISSUES for CKAP5 Gene
- Blood(4.6)
- Nervous system(4.6)
- Liver(4.6)
- Bone marrow(4.4)
- Skin(3.3)
- Intestine(3.2)
- Heart(3.1)
- Kidney(3.1)
- Lung(2.9)
- Muscle(2.8)
- Thyroid gland(2.7)
- Stomach(2.7)
- Adrenal gland(2.4)
- Eye(2.4)
- Pancreas(2.3)
- Spleen(2.2)
- Gall bladder(2)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for CKAP5
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CKAP5 Gene
Orthologs for CKAP5 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CKAP5 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CKAP5 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CKAP5 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CKAP5 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ckap5 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ckap5 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CKAP5 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CKAP5 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CKAP5 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ckap5 30 |
|
||
| Str.3305 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398198 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ckap5 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | msps 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011162 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | T08D2.8 31 |
|
OneToMany | |
| zyg-9 31 |
|
OneToMany | |||
| F54A3.2 31 |
|
OneToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STU2 31 33 |
|
OneToOne | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | MOR1 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os01g0816400 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2441 31 |
|
OneToOne |
- Species where no ortholog for CKAP5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CKAP5 Gene
- ENSEMBL:
- Gene Tree for CKAP5 (if available)
- TreeFam:
- Gene Tree for CKAP5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CKAP5: view image
Paralogs for CKAP5 Gene
No data available for Paralogs for CKAP5 Gene
Variants for CKAP5 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CKAP5 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1565739639 | Uncertain Significance: not provided | 46,795,619(-) | G/A | MISSENSE_VARIANT | |
| rs193921076 | Uncertain Significance: Malignant tumor of prostate | 46,809,784(-) | T/C | MISSENSE_VARIANT | |
| rs11038988 | - | p.Tyr785Cys |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3547703 | CNV | deletion | 23714750 |
| nsv1122612 | CNV | deletion | 24896259 |
| nsv1138017 | CNV | deletion | 24896259 |
| nsv472167 | CNV | novel sequence insertion | 20440878 |
Residual Variation Intolerance Score:
1.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.80;
47.52% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CKAP5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CKAP5
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKAP5 Gene
Disorders for CKAP5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| tylosis with esophageal cancer |
|
|
| macular degeneration, age-related, 6 |
|
|
| macular degeneration, age-related, 4 |
|
|
| epidermolysis bullosa, junctional, non-herlitz type |
|
|
| mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes |
|
|
Search CKAP5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CKAP5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CKAP5 Gene
Publications for CKAP5 Gene
- Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T … Kotani H (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 2 3 4
- Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors. (PMID: 8536682) Charrasse S … Larroque C (European journal of biochemistry 1995) 2 3 4
- A TOG Protein Confers Tension Sensitivity to Kinetochore-Microtubule Attachments. (PMID: 27156448) Miller MP … Biggins S (Cell 2016) 3 4
- TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation. (PMID: 25596274) Gutiérrez-Caballero C … Royle SJ (Biology open 2015) 3 4
- Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells. (PMID: 23251535) Nakamura S … Mimori-Kiyosue Y (PloS one 2012) 3 4
ExternalLinks
Products for CKAP5 Gene
- Custom Antibody ServicesOriGene Antibodies for CKAP5
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CKAP5
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins for CKAP5
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- Invitrogen Antibodies for CKAP5 (AFLGC-CKAP5)
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- VectorBuilder Custom and pre-made DNA vectors for CKAP5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CKAP5 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CKAP5 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CKAP5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CKAP5
- Addgene plasmids for CKAP5
- antibodies-online: Show 7 available CKAP5 Antibodies ranked by validation data
- Compare Top CKAP5 Antibodies
- antibodies-online: Search results for available CKAP5 related products ranked by validation data
- antibodies-online: Search results for available CKAP5 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for CKAP5
- Search Santa Cruz Biotechnology (SCBT) for CKAP5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CKAP5
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CKAP5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CKAP5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CKAP5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CKAP5
- Boster Bio Antibodies for CKAP5
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for CKAP5
Sources for CKAP5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB