Aliases for CKAP4 Gene

Aliases for CKAP4 Gene

  • Cytoskeleton Associated Protein 4 2 3 5
  • Cytoskeleton-Associated Protein 4 2 3 4
  • 63-KDa Cytoskeleton-Linking Membrane Protein 3 4
  • P63 3 4
  • Transmembrane Protein (63kD), Endoplasmic Reticulum/Golgi Intermediate Compartment 3
  • Type-II Transmembrane Protein P63 3
  • 63 KDa Membrane Protein 3
  • CLIMP-63 3
  • ERGIC-63 3
  • Climp-63 4
  • CLIMP63 3

External Ids for CKAP4 Gene

Previous GeneCards Identifiers for CKAP4 Gene

  • GC12M105742
  • GC12M106512
  • GC12M105134
  • GC12M106631
  • GC12M103692

Summaries for CKAP4 Gene

GeneCards Summary for CKAP4 Gene

CKAP4 (Cytoskeleton Associated Protein 4) is a Protein Coding gene. Diseases associated with CKAP4 include Interstitial Cystitis and Axenfeld-Rieger Syndrome, Type 3. Among its related pathways are Innate Immune System and Surfactant metabolism. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity. An important paralog of this gene is SMC1B.

UniProtKB/Swiss-Prot Summary for CKAP4 Gene

Gene Wiki entry for CKAP4 Gene

Additional gene information for CKAP4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CKAP4 Gene

Genomics for CKAP4 Gene

GeneHancer (GH) Regulatory Elements for CKAP4 Gene

Promoters and enhancers for CKAP4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J106299 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +1.9 1922 5.7 EP300 FOXK2 ZNF217 SIN3A TCF12 POLR2G SP1 BCLAF1 NONO PHF8 TCP11L2 CKAP4 NONHSAG012173.2 lnc-NUAK1-7 ENSG00000260329 POLR3B MTERF2 TMEM263
GH12J106244 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.2 +56.5 56472 6 ZSCAN5C NRF1 PHF8 JUND ZFX ZIC2 POLR2A ZBTB26 KLF7 ZBTB7A ENSG00000258355 lnc-NUAK1-6 CKAP4 ENSG00000277715 piR-33614-067 lnc-NUAK1-7
GH12J106305 Promoter/Enhancer 0.9 Ensembl ENCODE dbSUPER 500.7 -1.5 -1460 0.5 FOS CTCF POLR2A CKAP4 lnc-NUAK1-7 TCP11L2 NONHSAG012173.2 piR-52079-049
GH12J106073 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.9 +224.6 224581 12.6 ZSCAN5C TCF12 JUND FOS TEAD4 ZNF639 ZNF354C EP300 ZIC2 ZBTB10 MTERF2 ENSG00000260329 ENSG00000257545 RIC8B ENSG00000257890 CKAP4 RF00017-1241 NUAK1
GH12J107277 Enhancer 0.5 Ensembl 4.7 -973.7 -973722 1.2 SPI1 FOS GATA2 JUN POLR2A STAT3 GABPA ENSG00000200897 CKAP4 HSALNG0093769 SETP7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CKAP4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CKAP4

Top Transcription factor binding sites by QIAGEN in the CKAP4 gene promoter:
  • AhR
  • AML1a
  • Arnt
  • ER-alpha
  • HEN1
  • LCR-F1
  • MAZR
  • Pax-4a
  • SRF
  • SRF (504 AA)

Genomic Locations for CKAP4 Gene

Genomic Locations for CKAP4 Gene
66,399 bases
Minus strand
66,403 bases
Minus strand

Genomic View for CKAP4 Gene

Genes around CKAP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKAP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKAP4 Gene

Proteins for CKAP4 Gene

  • Protein details for CKAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytoskeleton-associated protein 4
    Protein Accession:
    Secondary Accessions:
    • Q504S5
    • Q53ES6

    Protein attributes for CKAP4 Gene

    602 amino acids
    Molecular mass:
    66022 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH94824.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for CKAP4 Gene

Post-translational modifications for CKAP4 Gene

  • Reversibly palmitoylated. Palmitoylation at Cys-100 by DHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization.
  • Increased phosphorylation during mitosis prevents binding to microtubules.
  • Glycosylation at Thr512
  • Ubiquitination at Lys213, Lys355, and Lys551
  • Modification sites at PhosphoSitePlus

Other Protein References for CKAP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CKAP4 Gene

Domains & Families for CKAP4 Gene

Gene Families for CKAP4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CKAP4 Gene


Suggested Antigen Peptide Sequences for CKAP4 Gene

GenScript: Design optimal peptide antigens:
  • 63 kDa membrane protein (CKAP4_HUMAN)
  • CKAP4 protein (Q6NWZ1_HUMAN)
genes like me logo Genes that share domains with CKAP4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CKAP4 Gene

Function for CKAP4 Gene

Molecular function for CKAP4 Gene

UniProtKB/Swiss-Prot Function:
High-affinity epithelial cell surface receptor for APF.
UniProtKB/Swiss-Prot Function:
Mediates the anchoring of the endoplasmic reticulum to microtubules.

Phenotypes From GWAS Catalog for CKAP4 Gene

Gene Ontology (GO) - Molecular Function for CKAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with CKAP4: view
genes like me logo Genes that share phenotypes with CKAP4: view

Animal Models for CKAP4 Gene

MGI Knock Outs for CKAP4:
  • Ckap4 Ckap4<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for CKAP4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CKAP4 Gene

Localization for CKAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKAP4 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear region upon APF-stimulation.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CKAP4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
lysosome 4
mitochondrion 2
golgi apparatus 2
extracellular 1
peroxisome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (1)
  • Cytosol (1)
  • Nuclear speckles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CKAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA,IBA 19401338
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005791 rough endoplasmic reticulum IDA,IBA 24454821
genes like me logo Genes that share ontologies with CKAP4: view

Pathways & Interactions for CKAP4 Gene

genes like me logo Genes that share pathways with CKAP4: view

Pathways by source for CKAP4 Gene

Gene Ontology (GO) - Biological Process for CKAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with CKAP4: view

No data available for SIGNOR curated interactions for CKAP4 Gene

Drugs & Compounds for CKAP4 Gene

(2) Drugs for CKAP4 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
10-DAB (10-Deacetylbaccatin) Pharma Precursor of antitumor compound Palitaxel and Docetaxel 0
ABT-751 (E7010) Pharma Inhibitor of microtubule polymerization,antimitotic 0

(2) ApexBio Compounds for CKAP4 Gene

Compound Action Cas Number
10-DAB (10-Deacetylbaccatin) Precursor of antitumor compound Palitaxel and Docetaxel 32981-86-5
ABT-751 (E7010) Inhibitor of microtubule polymerization,antimitotic 141430-65-1
genes like me logo Genes that share compounds with CKAP4: view

Drug Products

Transcripts for CKAP4 Gene

mRNA/cDNA for CKAP4 Gene

9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for CKAP4

Alternative Splicing Database (ASD) splice patterns (SP) for CKAP4 Gene

No ASD Table

Relevant External Links for CKAP4 Gene

GeneLoc Exon Structure for

Expression for CKAP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CKAP4 Gene

mRNA differential expression in normal tissues according to GTEx for CKAP4 Gene

This gene is overexpressed in Whole Blood (x5.9).

Protein differential expression in normal tissues from HIPED for CKAP4 Gene

This gene is overexpressed in Nasal epithelium (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CKAP4 Gene

Protein tissue co-expression partners for CKAP4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CKAP4

SOURCE GeneReport for Unigene cluster for CKAP4 Gene:


Evidence on tissue expression from TISSUES for CKAP4 Gene

  • Lung(4.7)
  • Liver(4.6)
  • Pancreas(4.3)
  • Spleen(4.3)
  • Skin(3.9)
  • Nervous system(3.1)
  • Eye(2.7)
genes like me logo Genes that share expression patterns with CKAP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CKAP4 Gene

Orthologs for CKAP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CKAP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CKAP4 31 30
  • 99.2 (n)
(Canis familiaris)
Mammalia CKAP4 31 30
  • 86.03 (n)
(Mus musculus)
Mammalia Ckap4 17 31 30
  • 84.21 (n)
(Bos Taurus)
Mammalia CKAP4 31 30
  • 83.5 (n)
(Rattus norvegicus)
Mammalia Ckap4 30
  • 81.07 (n)
(Ornithorhynchus anatinus)
Mammalia CKAP4 31
  • 71 (a)
(Monodelphis domestica)
Mammalia CKAP4 31
  • 57 (a)
(Gallus gallus)
Aves CKAP4 31 30
  • 61.95 (n)
(Anolis carolinensis)
Reptilia CKAP4 31
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ckap4 30
  • 47.54 (n)
Species where no ortholog for CKAP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CKAP4 Gene

Gene Tree for CKAP4 (if available)
Gene Tree for CKAP4 (if available)
Evolutionary constrained regions (ECRs) for CKAP4: view image

Paralogs for CKAP4 Gene

Paralogs for CKAP4 Gene Pseudogenes for CKAP4 Gene

genes like me logo Genes that share paralogs with CKAP4: view

Variants for CKAP4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CKAP4 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
715655 Benign: not provided 106,239,501(-) G/A SYNONYMOUS_VARIANT
715809 Likely Benign: not provided 106,239,384(-) G/A SYNONYMOUS_VARIANT
735481 Benign: not provided 106,240,125(-) C/T SYNONYMOUS_VARIANT
774901 Benign: not provided 106,239,095(-) A/C MISSENSE_VARIANT
rs3088113 - p.Ala348Thr

Additional dbSNP identifiers (rs#s) for CKAP4 Gene

Structural Variations from Database of Genomic Variants (DGV) for CKAP4 Gene

Variant ID Type Subtype PubMed ID
dgv2842n54 CNV gain 21841781
dgv2843n54 CNV gain 21841781
dgv2844n54 CNV gain+loss 21841781
dgv2845n54 CNV gain 21841781
dgv2846n54 CNV gain 21841781
dgv2847n54 CNV loss 21841781
dgv2848n54 CNV loss 21841781
dgv2849n54 CNV loss 21841781
dgv2850n54 CNV gain 21841781
esv25104 CNV loss 19812545
nsv1071052 CNV deletion 25765185
nsv1118246 CNV deletion 24896259
nsv560055 CNV loss 21841781
nsv560061 CNV gain 21841781
nsv560074 CNV gain+loss 21841781
nsv560087 CNV loss 21841781
nsv560088 CNV gain+loss 21841781
nsv560089 CNV loss 21841781

Variation tolerance for CKAP4 Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CKAP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKAP4 Gene

Disorders for CKAP4 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CKAP4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
interstitial cystitis
  • pbs
axenfeld-rieger syndrome, type 3
  • anterior segment mesenchymal dysgenesis
  • infective cystitis
steroid-induced glaucoma
  • corticosteroid-induced glaucoma
amelogenesis imperfecta
  • ai
- elite association - COSMIC cancer census association via MalaCards
Search CKAP4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CKAP4

genes like me logo Genes that share disorders with CKAP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CKAP4 Gene

Publications for CKAP4 Gene

  1. Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling. (PMID: 19144824) Planey SL … Zacharias DA (Molecular biology of the cell 2009) 3 4 23 54
  2. Phosphorylation controls CLIMP-63-mediated anchoring of the endoplasmic reticulum to microtubules. (PMID: 15703217) Vedrenne C … Hauri HP (Molecular biology of the cell 2005) 3 4 23 54
  3. A reversibly palmitoylated resident protein (p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein. (PMID: 8314870) Schweizer A … Hauri HP (Journal of cell science 1993) 2 3 4 54
  4. Climp-63-mediated binding of microtubules to the ER affects the lateral mobility of translocon complexes. (PMID: 17567679) Nikonov AV … Kreibich G (Journal of cell science 2007) 4 23 54
  5. CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients. (PMID: 17030514) Conrads TP … Keay SK (The Journal of biological chemistry 2006) 3 4 54

Products for CKAP4 Gene

Sources for CKAP4 Gene