This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, N... See more...

Aliases for CKAP2 Gene

Aliases for CKAP2 Gene

  • Cytoskeleton Associated Protein 2 2 3 5
  • TMAP 2 3 4
  • LB1 2 3 4
  • Tumor-Associated Microtubule-Associated Protein 2 3
  • Tumor- And Microtubule-Associated Protein 3 4
  • Cytoskeleton-Associated Protein 2 3 4
  • CTCL Tumor Antigen Se20-10 3 4
  • Se20-10 2 3
  • FLJ10749 2
  • CKAP2 5

External Ids for CKAP2 Gene

Previous GeneCards Identifiers for CKAP2 Gene

  • GC13P050997
  • GC13P047024
  • GC13P051966
  • GC13P050827
  • GC13P051927
  • GC13P053029
  • GC13P033768

Summaries for CKAP2 Gene

Entrez Gene Summary for CKAP2 Gene

  • This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]

GeneCards Summary for CKAP2 Gene

CKAP2 (Cytoskeleton Associated Protein 2) is a Protein Coding gene. An important paralog of this gene is CKAP2L.

UniProtKB/Swiss-Prot Summary for CKAP2 Gene

  • Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity).

Gene Wiki entry for CKAP2 Gene

Additional gene information for CKAP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CKAP2 Gene

Genomics for CKAP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CKAP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CKAP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CKAP2

Top Transcription factor binding sites by QIAGEN in the CKAP2 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • NF-Y
  • NF-YA
  • NF-YB
  • PPAR-alpha

Genomic Locations for CKAP2 Gene

Genomic Locations for CKAP2 Gene
chr13:52,455,360-52,476,631
(GRCh38/hg38)
Size:
21,272 bases
Orientation:
Plus strand
chr13:53,029,495-53,050,763
(GRCh37/hg19)
Size:
21,269 bases
Orientation:
Plus strand

Genomic View for CKAP2 Gene

Genes around CKAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CKAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CKAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CKAP2 Gene

Proteins for CKAP2 Gene

  • Protein details for CKAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWK9-CKAP2_HUMAN
    Recommended name:
    Cytoskeleton-associated protein 2
    Protein Accession:
    Q8WWK9
    Secondary Accessions:
    • A2BDE0
    • A5YM58
    • B4DR35
    • E9PD90
    • Q3KRA5
    • Q5VXB4
    • Q8IWV5
    • Q8IWV6
    • Q96FH9
    • Q9H012
    • Q9H0D0
    • Q9H988
    • Q9HC49
    • Q9NVG4

    Protein attributes for CKAP2 Gene

    Size:
    683 amino acids
    Molecular mass:
    76987 Da
    Quaternary structure:
    • Associates with alpha- and beta-tubulins.
    SequenceCaution:
    • Sequence=AAG33675.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH10901.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAI05807.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91788.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for CKAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CKAP2 Gene

Post-translational modifications for CKAP2 Gene

  • Ubiquitination at Lys70, Lys617, and Lys620
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CKAP2 Gene

Domains & Families for CKAP2 Gene

Gene Families for CKAP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CKAP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CKAP2 Gene

GenScript: Design optimal peptide antigens:
  • Cytoskeleton associated protein 2, isoform CRA_b (B2RMQ4_HUMAN)
  • Tumor- and microtubule-associated protein (CKAP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WWK9

UniProtKB/Swiss-Prot:

CKAP2_HUMAN :
  • Belongs to the CKAP2 family.
Family:
  • Belongs to the CKAP2 family.
genes like me logo Genes that share domains with CKAP2: view

Function for CKAP2 Gene

Molecular function for CKAP2 Gene

UniProtKB/Swiss-Prot Function:
Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated in primary human gastric cancers.

Phenotypes From GWAS Catalog for CKAP2 Gene

genes like me logo Genes that share phenotypes with CKAP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CKAP2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CKAP2 Gene

Localization for CKAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CKAP2 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CKAP2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
plasma membrane 2
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CKAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005819 spindle IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CKAP2: view

Pathways & Interactions for CKAP2 Gene

PathCards logo

SuperPathways for CKAP2 Gene

No Data Available

SIGNOR curated interactions for CKAP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CKAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IGI 16061649
GO:0006915 apoptotic process IEA --
GO:0007026 negative regulation of microtubule depolymerization IEA --
GO:0007049 cell cycle IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IGI 16061649
genes like me logo Genes that share ontologies with CKAP2: view

No data available for Pathways by source for CKAP2 Gene

Drugs & Compounds for CKAP2 Gene

(3) Drugs for CKAP2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vincristine Approved, Investigational Pharma Microtubule disrupter,antitumor agent 1073
10-DAB (10-Deacetylbaccatin) Pharma Precursor of antitumor compound Palitaxel and Docetaxel 0
ABT-751 (E7010) Pharma Inhibitor of microtubule polymerization,antimitotic 0

(3) ApexBio Compounds for CKAP2 Gene

Compound Action Cas Number
10-DAB (10-Deacetylbaccatin) Precursor of antitumor compound Palitaxel and Docetaxel 32981-86-5
ABT-751 (E7010) Inhibitor of microtubule polymerization,antimitotic 141430-65-1
Vincristine Microtubule disrupter,antitumor agent 2068-78-2
genes like me logo Genes that share compounds with CKAP2: view

Drug Products

Transcripts for CKAP2 Gene

mRNA/cDNA for CKAP2 Gene

4 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CKAP2

Alternative Splicing Database (ASD) splice patterns (SP) for CKAP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: -
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for CKAP2 Gene

GeneLoc Exon Structure for
CKAP2

Expression for CKAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CKAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CKAP2 Gene

This gene is overexpressed in Testis (32.4), Peripheral blood mononuclear cells (14.7), and Ovary (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CKAP2 Gene



Protein tissue co-expression partners for CKAP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CKAP2

SOURCE GeneReport for Unigene cluster for CKAP2 Gene:

Hs.444028

mRNA Expression by UniProt/SwissProt for CKAP2 Gene:

Q8WWK9-CKAP2_HUMAN
Tissue specificity: Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney.

Evidence on tissue expression from TISSUES for CKAP2 Gene

  • Lung(4.7)
  • Intestine(4.4)
  • Nervous system(4.2)
  • Stomach(2.9)
  • Pancreas(2.9)
  • Skin(2.8)
  • Kidney(2.7)
  • Bone(2.5)
  • Blood(2.3)
  • Bone marrow(2.1)
  • Heart(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with CKAP2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CKAP2 Gene

Orthologs for CKAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CKAP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CKAP2 30 31
  • 98.98 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CKAP2 30 31
  • 81.18 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CKAP2 30 31
  • 79.3 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ckap2 30 17 31
  • 75.18 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ckap2 30
  • 74.41 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 49 (a)
OneToMany
-- 31
  • 48 (a)
OneToMany
-- 31
  • 37 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 47 (a)
OneToMany
-- 31
  • 39 (a)
OneToMany
Chicken
(Gallus gallus)
Aves CKAP2 30 31
  • 54.46 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CKAP2 31
  • 31 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ckap2 30
  • 51.26 (n)
Str.6556 30
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-266i6.3 30
  • 46.51 (n)
CKAP2 31
  • 24 (a)
OneToOne
Species where no ortholog for CKAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CKAP2 Gene

ENSEMBL:
Gene Tree for CKAP2 (if available)
TreeFam:
Gene Tree for CKAP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CKAP2: view image

Paralogs for CKAP2 Gene

Paralogs for CKAP2 Gene

Pseudogenes.org Pseudogenes for CKAP2 Gene

genes like me logo Genes that share paralogs with CKAP2: view

Variants for CKAP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CKAP2 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
724262 Benign: not provided 52,461,155(+) A/G MISSENSE_VARIANT
788446 Likely Benign: not provided 52,461,604(+) C/T MISSENSE_VARIANT
790677 Benign: not provided 52,461,762(+) T/A SYNONYMOUS_VARIANT
790678 Benign: not provided 52,462,418(+) A/G MISSENSE_VARIANT
791501 Benign: not provided 52,473,831(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CKAP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CKAP2 Gene

Variant ID Type Subtype PubMed ID
esv1661627 CNV deletion 17803354
esv2423190 CNV insertion 19546169
esv3326145 CNV duplication 20981092
esv3632093 CNV loss 21293372
esv3632094 CNV loss 21293372
esv3892344 CNV loss 25118596
nsv1110855 OTHER inversion 24896259
nsv428288 CNV loss 18775914
nsv7242 OTHER inversion 18451855

Variation tolerance for CKAP2 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CKAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CKAP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CKAP2 Gene

Disorders for CKAP2 Gene

No disorders were found for CKAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CKAP2 Gene

Publications for CKAP2 Gene

  1. Identification of a novel cDNA, encoding a cytoskeletal associated protein, differentially expressed in diffuse large B cell lymphomas. (PMID: 9771967) Maouche-Chrétien L … Leroy-Viard K (Oncogene 1998) 2 3 4
  2. CKAP2 is necessary to ensure the faithful spindle bipolarity in a dividing diploid hepatocyte. (PMID: 27055594) Yoo BH … Bae CD (Biochemical and biophysical research communications 2016) 2 3
  3. Cdk1-cyclin B1-mediated phosphorylation of tumor-associated microtubule-associated protein/cytoskeleton-associated protein 2 in mitosis. (PMID: 19369249) Hong KU … Park J (The Journal of biological chemistry 2009) 3 23
  4. Characterization of mitosis-specific phosphorylation of tumor-associated microtubule-associated protein. (PMID: 19641375) Hong KU … Park J (Experimental & molecular medicine 2009) 3 23
  5. Transient phosphorylation of tumor associated microtubule associated protein (TMAP)/cytoskeleton associated protein 2 (CKAP2) at Thr-596 during early phases of mitosis. (PMID: 18779650) Hong KU … Hong KM (Experimental & molecular medicine 2008) 3 23

Products for CKAP2 Gene

  • Signalway Proteins for CKAP2

Sources for CKAP2 Gene