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Aliases for CITED4 Gene

Aliases for CITED4 Gene

  • Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 4 2 3 5
  • Transcriptional Co-Activator 4 2 3
  • MSG1-Related Protein 2 3 4
  • MRG-2 3 4
  • Cbp/P300-Interacting Transactivator, With Glu/Asp Rich Carboxy-Terminal Domain, 4 2
  • Cbp/P300-Interacting Transactivator 4 3
  • MRG2 4

External Ids for CITED4 Gene

Previous GeneCards Identifiers for CITED4 Gene

  • GC01M041362
  • GC01M040330
  • GC01M040790
  • GC01M040740
  • GC01M040995
  • GC01M041099
  • GC01M039444

Summaries for CITED4 Gene

Entrez Gene Summary for CITED4 Gene

  • The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]

GeneCards Summary for CITED4 Gene

CITED4 (Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 4) is a Protein Coding gene. Among its related pathways are Gene Expression and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is CITED1.

UniProtKB/Swiss-Prot for CITED4 Gene

  • Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.

Additional gene information for CITED4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CITED4 Gene

Genomics for CITED4 Gene

GeneHancer (GH) Regulatory Elements for CITED4 Gene

Promoters and enhancers for CITED4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J040943 Enhancer 1.3 Ensembl ENCODE dbSUPER 19.3 -83.0 -83014 2.9 ELF3 RAD21 RARA RFX5 YY1 EGR1 ZNF366 RCOR1 THAP11 MIXL1 UBE2V1P8 CITED4 ENSG00000229528 CTPS1 MIR30C1 MIR30E NFYC EXO5 ENSG00000235358 GC01P040947
GH01J040948 Enhancer 1.3 Ensembl ENCODE dbSUPER 16.7 -86.5 -86536 1.5 PKNOX1 ARNT SIN3A ARID2 ZNF143 FOS DEK REST ZNF592 SMARCA4 GC01P040947 CITED4 ENSG00000229528 MIR30E MIR30C1 NFYC ENSG00000235358 GC01M040907
GH01J040897 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14.4 -37.9 -37923 6.1 PKNOX1 CLOCK NFIB NEUROD1 RAD21 RFX5 ZNF143 FOS RCOR1 HCFC1 CITED4 PIR51186 LOC100128362
GH01J040859 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 10.3 -2.6 -2638 11.5 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A YY1 ZNF766 CBX5 ENSG00000229528 GC01M040863 EXO5 RLF TRIT1 NFYC CITED4 PIR44205
GH01J040888 Enhancer 0.8 ENCODE dbSUPER 22.1 -27.6 -27608 2 NFIA NFIB TEAD1 CEBPG ZEB2 TEAD3 ATF4 CEBPA KDM1A CITED4 PIR44205 ENSG00000229528
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CITED4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CITED4 gene promoter:

Genomic Locations for CITED4 Gene

Genomic Locations for CITED4 Gene
chr1:40,861,051-40,862,366
(GRCh38/hg38)
Size:
1,316 bases
Orientation:
Minus strand
chr1:41,326,728-41,328,018
(GRCh37/hg19)

Genomic View for CITED4 Gene

Genes around CITED4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CITED4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CITED4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CITED4 Gene

Proteins for CITED4 Gene

  • Protein details for CITED4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RK1-CITE4_HUMAN
    Recommended name:
    Cbp/p300-interacting transactivator 4
    Protein Accession:
    Q96RK1

    Protein attributes for CITED4 Gene

    Size:
    184 amino acids
    Molecular mass:
    18569 Da
    Quaternary structure:
    • Interacts via its C-terminal region with the CH1 domain of CREBBP and EP300. Interacts with all TFAP2/AP-2 isoforms.

neXtProt entry for CITED4 Gene

Post-translational modifications for CITED4 Gene

No Post-translational modifications

Other Protein References for CITED4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CITED4 Gene

Domains & Families for CITED4 Gene

Gene Families for CITED4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CITED4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CITED4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RK1

UniProtKB/Swiss-Prot:

CITE4_HUMAN :
  • Belongs to the CITED family.
Family:
  • Belongs to the CITED family.
genes like me logo Genes that share domains with CITED4: view

Function for CITED4 Gene

Molecular function for CITED4 Gene

UniProtKB/Swiss-Prot Function:
Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.

Phenotypes From GWAS Catalog for CITED4 Gene

Gene Ontology (GO) - Molecular Function for CITED4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IEA,ISS --
genes like me logo Genes that share ontologies with CITED4: view
genes like me logo Genes that share phenotypes with CITED4: view

Animal Models for CITED4 Gene

MGI Knock Outs for CITED4:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CITED4 Gene

Localization for CITED4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CITED4 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CITED4 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CITED4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CITED4: view

Pathways & Interactions for CITED4 Gene

genes like me logo Genes that share pathways with CITED4: view

Gene Ontology (GO) - Biological Process for CITED4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0032502 developmental process IBA --
genes like me logo Genes that share ontologies with CITED4: view

No data available for SIGNOR curated interactions for CITED4 Gene

Drugs & Compounds for CITED4 Gene

No Compound Related Data Available

Transcripts for CITED4 Gene

mRNA/cDNA for CITED4 Gene

(53) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CITED4 Gene

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CITED4 Gene

No ASD Table

Relevant External Links for CITED4 Gene

GeneLoc Exon Structure for
CITED4
ECgene alternative splicing isoforms for
CITED4

Expression for CITED4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CITED4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CITED4 Gene:

CITED4

SOURCE GeneReport for Unigene cluster for CITED4 Gene:

Hs.355820

mRNA Expression by UniProt/SwissProt for CITED4 Gene:

Q96RK1-CITE4_HUMAN
Tissue specificity: Expressed in most tissues examined with highest levels of expression in heart, liver, skeletal muscle and pancreas. Also expressed in bladder cell line ECV-304 and in various breast cancer cell lines. Also detected in both in situ and invasive breast tumors where its expression is down-regulated and mostly restricted to the cytoplasm of malignant epithelium. Down-regulation of expression is associated with elevated levels of HIF1A and increased tumor growth and angiogenesis.
genes like me logo Genes that share expression patterns with CITED4: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CITED4 Gene

Orthologs for CITED4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CITED4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CITED4 34 33
  • 99.09 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CITED4 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CITED4 34 33
  • 87.25 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cited4 33
  • 79.58 (n)
mouse
(Mus musculus)
Mammalia Cited4 16 34 33
  • 79.14 (n)
oppossum
(Monodelphis domestica)
Mammalia CITED4 34
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves CITED3 34
  • 32 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cited4b 34
  • 25 (a)
OneToMany
cited4a 34
  • 25 (a)
OneToMany
Species where no ortholog for CITED4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CITED4 Gene

ENSEMBL:
Gene Tree for CITED4 (if available)
TreeFam:
Gene Tree for CITED4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CITED4: view image

Paralogs for CITED4 Gene

Paralogs for CITED4 Gene

genes like me logo Genes that share paralogs with CITED4: view

Variants for CITED4 Gene

Sequence variations from dbSNP and Humsavar for CITED4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000739326 -- 40,862,603(-) C/G upstream_transcript_variant
rs1001233353 -- 40,863,485(-) G/A upstream_transcript_variant
rs1001767702 -- 40,863,222(-) A/G upstream_transcript_variant
rs1002099850 -- 40,862,205(-) T/C 5_prime_UTR_variant
rs1002169413 -- 40,864,205(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CITED4 Gene

Variant ID Type Subtype PubMed ID
nsv1078364 CNV deletion 25765185

Variation tolerance for CITED4 Gene

Gene Damage Index Score: 10.93; 91.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CITED4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CITED4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CITED4 Gene

Disorders for CITED4 Gene

Additional Disease Information for CITED4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CITED4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CITED4 Gene

Publications for CITED4 Gene

  1. Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2. (PMID: 11744733) Bragança J … Bhattacharya S (The Journal of biological chemistry 2002) 2 3 4 58
  2. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha. (PMID: 15342390) Fox SB … Harris AL (Cancer research 2004) 3 4 58
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58

Products for CITED4 Gene

Sources for CITED4 Gene

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