Aliases for CITED4 Gene
External Ids for CITED4 Gene
Previous GeneCards Identifiers for CITED4 Gene
The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]
GeneCards Summary for CITED4 Gene
CITED4 (Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 4) is a Protein Coding gene. Diseases associated with CITED4 include Adult Oligodendroglioma and Breast Cancer. Among its related pathways are Gene Expression and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is CITED2.
UniProtKB/Swiss-Prot Summary for CITED4 Gene
Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.