Aliases for CISD3 Gene
External Ids for CISD3 Gene
Previous GeneCards Identifiers for CISD3 Gene
CISD3 is a member of the CDGSH domain-containing family, which may play a role in regulating electron transport and oxidative phosphorylation (Wiley et al., 2007 [PubMed 17376863]).[supplied by OMIM, Apr 2008]
GeneCards Summary for CISD3 Gene
CISD3 (CDGSH Iron Sulfur Domain 3) is a Protein Coding gene. Diseases associated with CISD3 include Wolfram Syndrome 2 and Wolfram Syndrome. Gene Ontology (GO) annotations related to this gene include 2 iron, 2 sulfur cluster binding. An important paralog of this gene is CISD2.
UniProtKB/Swiss-Prot Summary for CISD3 Gene
Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function.