Aliases for CISD3 Gene
Aliases for CISD3 Gene
External Ids for CISD3 Gene
- HGNC: 27578
- Entrez Gene: 284106
- Ensembl: ENSG00000277972
- OMIM: 611933
- UniProtKB: P0C7P0
Previous GeneCards Identifiers for CISD3 Gene
- GC17U900840
- GC17P034138
- GC17P036886
- GC17P032655
Summaries for CISD3 Gene
-
CISD3 is a member of the CDGSH domain-containing family, which may play a role in regulating electron transport and oxidative phosphorylation (Wiley et al., 2007 [PubMed 17376863]).[supplied by OMIM, Apr 2008]
GeneCards Summary for CISD3 Gene
CISD3 (CDGSH Iron Sulfur Domain 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include 2 iron, 2 sulfur cluster binding.
UniProtKB/Swiss-Prot for CISD3 Gene
-
Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CISD3 Gene
Genomics for CISD3 Gene
GeneHancer (GH) Regulatory Elements for CISD3 Gene
Promoters and enhancers for CISD3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CISD3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CISD3 gene promoter:
-
- Pax-5
- Meis-1
- HOXA9B
- HOXA9
- NF-1
- Meis-1b
- GATA-3
- NRSF form 1
- NRSF form 2
- ZIC2
Regulatory Element Products
Genomic Locations for CISD3 Gene
Genomic Locations for CISD3 Gene
- chr17:38,730,235-38,735,605
- (GRCh38/hg38)
- Size:
- 5,371 bases
- Orientation:
- Plus strand
- chr17:36,886,488-36,891,858
- (GRCh37/hg19)
- Size:
- 5,371 bases
- Orientation:
- Plus strand
Genomic View for CISD3 Gene
Genes around CISD3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by Entrez Gene
- 17q12 by HGNC
- 17q12 by Ensembl
CISD3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CISD3 Gene
Proteins for CISD3 Gene
-
Protein details for CISD3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0C7P0-CISD3_HUMAN
- Recommended name:
- CDGSH iron-sulfur domain-containing protein 3, mitochondrial
- Protein Accession:
- P0C7P0
Protein attributes for CISD3 Gene
- Size:
- 127 amino acids
- Molecular mass:
- 14216 Da
- Cofactor:
- Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
- Quaternary structure:
-
- Monomer.
Protein Expression for CISD3 Gene
Post-translational modifications for CISD3 Gene
Other Protein References for CISD3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CISD3
- Invitrogen Antibodies for CISD3 (AFLGC-CISD3)
- Search GeneTex for Antibodies for CISD3
Protein Products
-
OriGene Purified Proteins for CISD3
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- Search GeneTex for Proteins for CISD3
Assay Products
No data available for DME Specific Peptides for CISD3 Gene
Domains & Families for CISD3 Gene
Gene Families for CISD3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CISD3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CISD3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P0C7P0- Family:
-
- Belongs to the CISD protein family.
Function for CISD3 Gene
Molecular function for CISD3 Gene
- UniProtKB/Swiss-Prot Function:
- Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function.
Phenotypes From GWAS Catalog for CISD3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0051536 | iron-sulfur cluster binding | IEA | -- |
| GO:0051537 | 2 iron, 2 sulfur cluster binding | IEA | -- |
Phenotypes for CISD3 Gene
- GenomeRNAi human phenotypes for CISD3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
-
OriGene CRISPR knockouts for CISD3
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- genomics-online: gRNA clones - Search results for 81 available CISD3 gene related products
- Overview of 81 available CISD3 gene related products
- Applied Biological Materials CRISPR for CISD3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CISD3
- GenScript: Design CRISPR guide RNA sequences for CISD3
miRNA for CISD3 Gene
- miRTarBase miRNAs that target CISD3
-
- hsa-mir-148b-5p (MIRT286985)
- hsa-mir-6874-3p (MIRT286991)
- hsa-mir-4307 (MIRT615078)
- hsa-mir-6738-3p (MIRT615079)
- hsa-mir-7152-5p (MIRT615080)
- hsa-mir-3074-5p (MIRT615081)
- hsa-mir-5001-3p (MIRT615082)
- hsa-mir-4727-5p (MIRT615083)
- hsa-mir-6867-5p (MIRT615084)
- hsa-mir-6781-3p (MIRT615085)
- hsa-mir-2682-3p (MIRT615086)
- hsa-mir-1914-5p (MIRT615087)
- hsa-mir-1281 (MIRT659489)
- hsa-mir-6516-5p (MIRT659490)
- hsa-mir-455-3p (MIRT659491)
- hsa-mir-6881-3p (MIRT659492)
- hsa-mir-891a-3p (MIRT659493)
- hsa-mir-4711-5p (MIRT659494)
- hsa-mir-7112-3p (MIRT659495)
- hsa-mir-6499-3p (MIRT659496)
- hsa-mir-6804-3p (MIRT659497)
- hsa-mir-877-3p (MIRT659498)
- hsa-mir-660-3p (MIRT659499)
- hsa-mir-5193 (MIRT659500)
- hsa-mir-1306-5p (MIRT659501)
miRNA Products
Inhibitory RNA Products
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- Overview of 81 available CISD3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CISD3
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CISD3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CISD3 Gene
Localization for CISD3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CISD3 Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 4 |
| extracellular | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0043231 | intracellular membrane-bounded organelle | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CISD3 Gene
Pathways & Interactions for CISD3 Gene
No Data Available
Interacting Proteins for CISD3 Gene
No data available for Pathways by source and SIGNOR curated interactions for CISD3 Gene
Transcripts for CISD3 Gene
mRNA/cDNA for CISD3 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (55) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000613478 2074 bps (uc010wds.2)
- ENST00000619858 2326 bps (uc060end.1)
- ENST00000616128 773 bps (uc060ene.1)
Unigene Clusters for CISD3 Gene
- CDGSH iron sulfur domain 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CISD3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CISD3
- genomics-online: gRNA clones - Search results for 81 available CISD3 gene related products
- Overview of 81 available CISD3 gene related products
- Applied Biological Materials CRISPR for CISD3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CISD3
- GenScript: Design CRISPR guide RNA sequences for CISD3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CISD3
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CISD3
- genomics-online: shRNA clones - Search results for 81 available CISD3 gene related products
- Overview of 81 available CISD3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CISD3
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- Applied Biological Materials Clones for CISD3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CISD3 Gene
mRNA differential expression in normal tissues according to GTEx for CISD3 Gene
This gene is overexpressed in Liver (x4.9).
This gene is overexpressed in Liver (19.5) and Adrenal (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CISD3 Gene
NURSA nuclear receptor signaling pathways regulating expression of CISD3 Gene:
CISD3SOURCE GeneReport for Unigene cluster for CISD3 Gene:
Hs.713595Evidence on tissue expression from TISSUES for CISD3 Gene
- Nervous system(4.3)
- Eye(2.5)
Primer Products
-
OriGene qPCR primer pairs for CISD3
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CISD3 Gene
Orthologs for CISD3 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CISD3 33 |
|
||
| cow (Bos Taurus) |
Mammalia | CISD3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cisd3 33 |
|
||
| Cisd3b 16 |
|
||||
| dog (Canis familiaris) |
Mammalia | CISD3 33 |
|
- Species where no ortholog for CISD3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for CISD3 Gene
- ENSEMBL:
- Gene Tree for CISD3 (if available)
- TreeFam:
- Gene Tree for CISD3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CISD3: view image
Paralogs for CISD3 Gene
No data available for Paralogs for CISD3 Gene
Variants for CISD3 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000215071 | -- | 38,730,592(+) | C/G/T | intron_variant | |
| rs1000227757 | -- | 38,731,012(+) | G/A | intron_variant | |
| rs1000257530 | -- | 38,731,266(+) | C/T | intron_variant | |
| rs1000711107 | -- | 38,730,913(+) | G/A | intron_variant | |
| rs1001158702 | -- | 38,732,002(+) | C/T | intron_variant |
Gene Damage Index Score:
7.38;
81.71% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CISD3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CISD3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CISD3 Gene
Disorders for CISD3 Gene
Additional Disease Information for CISD3
No disorders were found for CISD3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CISD3 Gene
Publications for CISD3 Gene
- MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. (PMID: 17376863) Wiley SE … Dixon JE (Proceedings of the National Academy of Sciences of the United States of America 2007) 2 3 4 58
- Structure of the human monomeric NEET protein MiNT and its role in regulating iron and reactive oxygen species in cancer cells. (PMID: 29259115) Lipper CH … Jennings PA (Proceedings of the National Academy of Sciences of the United States of America 2018) 3 4 58
- The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. (PMID: 17584744) Wiley SE … Dixon JE (The Journal of biological chemistry 2007) 2 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 58
Products for CISD3 Gene
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- Overview of 81 available CISD3 gene related products
- genomics-online: shRNA clones - Search results for 81 available CISD3 gene related products
- Overview of 81 available CISD3 gene related products
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Sources for CISD3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
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- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
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- (125) NCBI Bookshelf
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- (127) Gene Damage Index
- (128) ViGene Biosciences
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- (132) FANTOM5
- (133) ENCODE
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
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- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt