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CISD3 is a member of the CDGSH domain-containing family, which may play a role in regulating electron transport and oxidative phosphorylation (Wiley et al., 2007 [PubMed 17376863]).[supplied by OMIM, Apr 2008]
CISD3 (CDGSH Iron Sulfur Domain 3) is a Protein Coding gene. Diseases associated with CISD3 include Wolfram Syndrome 2 and Wolfram Syndrome. Gene Ontology (GO) annotations related to this gene include 2 iron, 2 sulfur cluster binding. An important paralog of this gene is CISD2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0046872 | metal ion binding | IEA,IDA | 29259115 |
GO:0051536 | iron-sulfur cluster binding | IEA | -- |
GO:0051537 | 2 iron, 2 sulfur cluster binding | IDA | 29259115 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IEA,IDA | 17376863 |
GO:0043231 | intracellular membrane-bounded organelle | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0106034 | protein maturation by [2Fe-2S] cluster transfer | IDA | 29259115 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CISD3 30 |
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Cow (Bos Taurus) |
Mammalia | CISD3 30 |
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Mouse (Mus musculus) |
Mammalia | Cisd3 30 17 |
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Cisd3b 17 |
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Dog (Canis familiaris) |
Mammalia | CISD3 30 |
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Disorder | Aliases | PubMed IDs |
---|---|---|
wolfram syndrome 2 |
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wolfram syndrome |
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