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Aliases for CISD3 Gene

Aliases for CISD3 Gene

  • CDGSH Iron Sulfur Domain 3 2 3 5
  • Mitochondrial Inner NEET Protein 3 4
  • MitoNEET-Related Protein 2 3 4
  • MitoNEET Related 2 2 3
  • Miner2 3 4
  • MiNT 3 4
  • CDGSH Iron-Sulfur Domain-Containing Protein 3, Mitochondrial 3

External Ids for CISD3 Gene

Previous GeneCards Identifiers for CISD3 Gene

  • GC17U900840
  • GC17P034138
  • GC17P036886
  • GC17P032655

Summaries for CISD3 Gene

Entrez Gene Summary for CISD3 Gene

  • CISD3 is a member of the CDGSH domain-containing family, which may play a role in regulating electron transport and oxidative phosphorylation (Wiley et al., 2007 [PubMed 17376863]).[supplied by OMIM, Apr 2008]

GeneCards Summary for CISD3 Gene

CISD3 (CDGSH Iron Sulfur Domain 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include 2 iron, 2 sulfur cluster binding.

UniProtKB/Swiss-Prot for CISD3 Gene

  • Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function.

Additional gene information for CISD3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CISD3 Gene

Genomics for CISD3 Gene

GeneHancer (GH) Regulatory Elements for CISD3 Gene

Promoters and enhancers for CISD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J038724 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 658.9 -0.8 -773 10.8 HDGF CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CISD3 ENSG00000279119 LASP1 CDK12 MED1 PCGF2 LOC105371762 RPL23 RPL19 FBXL20
GH17J038699 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.5 -26.6 -26577 7.8 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 MLLT6 GC17P038706 MIR4734 LOC105371764 ENSG00000277969 CDK12 LOC105371762 SNORA21 MED1 PCGF2
GH17J038745 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.8 +19.5 19538 8.6 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PCGF2 PSMB3 LOC100287808 CDK12 MED1 LOC105371762 SNORA21 RPL19 RPL23 STARD3
GH17J038673 Promoter/Enhancer 1.5 Ensembl ENCODE 12.3 -55.5 -55513 1.7 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 EPOP GC17M038673 PCGF2 PIP4K2B MLLT6 CISD3 PSMB3 CWC25
GH17J038677 Enhancer 1.2 Ensembl ENCODE 12.3 -53.0 -53034 0.8 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF207 ZNF143 SP3 MXD4 EPOP MLLT6 PCGF2 CISD3 PSMB3 PIP4K2B CWC25 GC17M038684
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CISD3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CISD3 gene promoter:
  • Pax-5
  • Meis-1
  • HOXA9B
  • HOXA9
  • NF-1
  • Meis-1b
  • GATA-3
  • NRSF form 1
  • NRSF form 2
  • ZIC2

Genomic Locations for CISD3 Gene

Genomic Locations for CISD3 Gene
chr17:38,730,235-38,735,605
(GRCh38/hg38)
Size:
5,371 bases
Orientation:
Plus strand
chr17:36,886,488-36,891,858
(GRCh37/hg19)
Size:
5,371 bases
Orientation:
Plus strand

Genomic View for CISD3 Gene

Genes around CISD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CISD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CISD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CISD3 Gene

Proteins for CISD3 Gene

  • Protein details for CISD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7P0-CISD3_HUMAN
    Recommended name:
    CDGSH iron-sulfur domain-containing protein 3, mitochondrial
    Protein Accession:
    P0C7P0

    Protein attributes for CISD3 Gene

    Size:
    127 amino acids
    Molecular mass:
    14216 Da
    Cofactor:
    Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CISD3 Gene

neXtProt entry for CISD3 Gene

Post-translational modifications for CISD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CISD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CISD3 Gene

Domains & Families for CISD3 Gene

Gene Families for CISD3 Gene

Protein Domains for CISD3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CISD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C7P0

UniProtKB/Swiss-Prot:

CISD3_HUMAN :
  • Belongs to the CISD protein family.
Family:
  • Belongs to the CISD protein family.
genes like me logo Genes that share domains with CISD3: view

Function for CISD3 Gene

Molecular function for CISD3 Gene

UniProtKB/Swiss-Prot Function:
Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function.

Phenotypes From GWAS Catalog for CISD3 Gene

Gene Ontology (GO) - Molecular Function for CISD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding IEA --
GO:0051537 2 iron, 2 sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with CISD3: view

Phenotypes for CISD3 Gene

genes like me logo Genes that share phenotypes with CISD3: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CISD3 Gene

Localization for CISD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CISD3 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CISD3 gene
Compartment Confidence
mitochondrion 4
extracellular 2

Gene Ontology (GO) - Cellular Components for CISD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with CISD3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CISD3 Gene

Pathways & Interactions for CISD3 Gene

SuperPathways for CISD3 Gene

No Data Available

Interacting Proteins for CISD3 Gene

Selected Interacting proteins: P0C7P0-CISD3_HUMAN for CISD3 Gene via IID

Symbol External ID(s) Details
NCAPD3

Gene Ontology (GO) - Biological Process for CISD3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CISD3 Gene

Drugs & Compounds for CISD3 Gene

No Compound Related Data Available

Transcripts for CISD3 Gene

mRNA/cDNA for CISD3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(55) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CISD3 Gene

CDGSH iron sulfur domain 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CISD3 Gene

No ASD Table

Relevant External Links for CISD3 Gene

GeneLoc Exon Structure for
CISD3
ECgene alternative splicing isoforms for
CISD3

Expression for CISD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CISD3 Gene

mRNA differential expression in normal tissues according to GTEx for CISD3 Gene

This gene is overexpressed in Liver (x4.9).

Protein differential expression in normal tissues from HIPED for CISD3 Gene

This gene is overexpressed in Liver (19.5) and Adrenal (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CISD3 Gene



Protein tissue co-expression partners for CISD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CISD3 Gene:

CISD3

SOURCE GeneReport for Unigene cluster for CISD3 Gene:

Hs.713595

Evidence on tissue expression from TISSUES for CISD3 Gene

  • Nervous system(4.3)
  • Eye(2.5)
genes like me logo Genes that share expression patterns with CISD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CISD3 Gene

Orthologs for CISD3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CISD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CISD3 33
  • 99.21 (n)
cow
(Bos Taurus)
Mammalia CISD3 33
  • 87.63 (n)
mouse
(Mus musculus)
Mammalia Cisd3 33
  • 85.98 (n)
Cisd3b 16
dog
(Canis familiaris)
Mammalia CISD3 33
  • 85.04 (n)
Species where no ortholog for CISD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CISD3 Gene

ENSEMBL:
Gene Tree for CISD3 (if available)
TreeFam:
Gene Tree for CISD3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CISD3: view image

Paralogs for CISD3 Gene

No data available for Paralogs for CISD3 Gene

Variants for CISD3 Gene

Sequence variations from dbSNP and Humsavar for CISD3 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000215071 -- 38,730,592(+) C/G/T intron_variant
rs1000227757 -- 38,731,012(+) G/A intron_variant
rs1000257530 -- 38,731,266(+) C/T intron_variant
rs1000711107 -- 38,730,913(+) G/A intron_variant
rs1001158702 -- 38,732,002(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CISD3 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv470585 CNV loss 18288195
nsv833438 CNV loss 17160897

Variation tolerance for CISD3 Gene

Gene Damage Index Score: 7.38; 81.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CISD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CISD3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CISD3 Gene

Disorders for CISD3 Gene

Additional Disease Information for CISD3

No disorders were found for CISD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CISD3 Gene

Publications for CISD3 Gene

  1. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. (PMID: 17376863) Wiley SE … Dixon JE (Proceedings of the National Academy of Sciences of the United States of America 2007) 2 3 4 58
  2. Structure of the human monomeric NEET protein MiNT and its role in regulating iron and reactive oxygen species in cancer cells. (PMID: 29259115) Lipper CH … Jennings PA (Proceedings of the National Academy of Sciences of the United States of America 2018) 3 4 58
  3. The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. (PMID: 17584744) Wiley SE … Dixon JE (The Journal of biological chemistry 2007) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 58

Products for CISD3 Gene

Sources for CISD3 Gene

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