Aliases for CISD2 Gene
External Ids for CISD2 Gene
Previous HGNC Symbols for CISD2 Gene
Previous GeneCards Identifiers for CISD2 Gene
The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]
GeneCards Summary for CISD2 Gene
CISD2 (CDGSH Iron Sulfur Domain 2) is a Protein Coding gene. Diseases associated with CISD2 include Wolfram Syndrome 2 and Wolfram Syndrome. Among its related pathways are Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include 2 iron, 2 sulfur cluster binding. An important paralog of this gene is CISD1.
UniProtKB/Swiss-Prot Summary for CISD2 Gene
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.