Aliases for CIRBP Gene
External Ids for CIRBP Gene
Previous GeneCards Identifiers for CIRBP Gene
GeneCards Summary for CIRBP Gene
CIRBP (Cold Inducible RNA Binding Protein) is a Protein Coding gene. Diseases associated with CIRBP include Cryptorchidism, Unilateral Or Bilateral and Acth-Secreting Pituitary Adenoma. Among its related pathways are Translational Control and DNA Damage. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBM3.
UniProtKB/Swiss-Prot Summary for CIRBP Gene
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.