Aliases for CIR1 Gene
External Ids for CIR1 Gene
Previous GeneCards Identifiers for CIR1 Gene
GeneCards Summary for CIR1 Gene
CIR1 (Corepressor Interacting With RBPJ, 1) is a Protein Coding gene. Diseases associated with CIR1 include Neurodermatitis. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Notch Signaling Pathway (WikiPathways). Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription corepressor activity.
UniProtKB/Swiss-Prot Summary for CIR1 Gene
May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.