Aliases for CIR1 Gene

Aliases for CIR1 Gene

  • Corepressor Interacting With RBPJ, CIR1 2 3
  • Corepressor Interacting With RBPJ, 1 2 3 5
  • Recepin 2 3 4
  • CIR 2 3 4
  • CBF1 (RBPJ) Interacting Corepressor 1 2 3
  • Corepressor Interacting With RBPJ 1 3 4
  • CBF1-Interacting Corepressor 3 4
  • CBF1 Interacting Corepressor 2
  • CIR1 5

External Ids for CIR1 Gene

Previous GeneCards Identifiers for CIR1 Gene

  • GC02M174922
  • GC02M175212
  • GC02M167093

Summaries for CIR1 Gene

GeneCards Summary for CIR1 Gene

CIR1 (Corepressor Interacting With RBPJ, CIR1) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Notch Signaling Pathway (WikiPathways). Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription corepressor activity.

UniProtKB/Swiss-Prot Summary for CIR1 Gene

  • May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.

Gene Wiki entry for CIR1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CIR1 Gene

Genomics for CIR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CIR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J174394 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.2 163 3.1 CREB1 GATAD2A ZNF629 TFE3 RFX1 LEF1 IKZF1 NFKBIZ POLR2A ZNF7 SCRN3 CIR1 L13304-021 lnc-GPR155-2 CHN1 OLA1 GPR155 lnc-GPR155-3 SP9
GH02J174439 Promoter 0.6 EPDnew 600.3 -44.3 -44307 0.1 PKNOX1 MEIS2 GATA2 CIR1 lnc-CIR1-3 piR-45035-115 SCRN3 GPR155
GH02J175180 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 10 -785.6 -785588 2.6 SP1 CREB1 GATAD2A HNRNPL PRDM10 ZNF629 ZNF512 LEF1 IKZF1 NFKBIZ lnc-ATF2-1 lnc-SCRN3-10 piR-59456 ATF2 ATP5MC3 HOXD9 HOXD4 CHN1 OLA1 CIR1
GH02J174585 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.5 -197.9 -197903 17 SP1 CREB1 POLR2A FOXA1 STAT3 PRDM1 RELA SMAD5 TCF12 IKZF2 WIPF1 ENSG00000237798 CIR1 GPR155 lnc-GPR155-5 ENSG00000236449
GH02J175234 Enhancer 0.8 ENCODE 11.3 -837.9 -837856 0.2 ZNF221 ZNF629 ZNF174 JUND REST ZNF501 ATF7 ZBTB20 SP1 ZNF639 CIR1 ATF2 HOXD3 HSALNG0020531 ATP5MC3 LNPK
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CIR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CIR1

Genomic Locations for CIR1 Gene

Genomic Locations for CIR1 Gene
chr2:174,348,022-174,395,712
(GRCh38/hg38)
Size:
47,691 bases
Orientation:
Minus strand
chr2:175,212,750-175,260,443
(GRCh37/hg19)
Size:
47,694 bases
Orientation:
Minus strand

Genomic View for CIR1 Gene

Genes around CIR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIR1 Gene

Proteins for CIR1 Gene

  • Protein details for CIR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X95-CIR1_HUMAN
    Recommended name:
    Corepressor interacting with RBPJ 1
    Protein Accession:
    Q86X95
    Secondary Accessions:
    • A6NFI6
    • A8K8M4
    • O95367
    • Q12804
    • Q4G1B9
    • Q6PJI4
    • Q8IWI2

    Protein attributes for CIR1 Gene

    Size:
    450 amino acids
    Molecular mass:
    52313 Da
    Quaternary structure:
    • Interacts with RP9, SNW1, SFRS1, SFRS2,U2AF1, RBPJ, SAP30, HDAC2 NKAP and NEK6. Interacts with Epstein-Barr virus RPMS1. Component of the histone deacetylase complex. Component of the Notch corepressor complex. Interacts with NKAPL (By similarity).
    SequenceCaution:
    • Sequence=AAA17853.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH21175.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH38987.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for CIR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CIR1 Gene

Post-translational modifications for CIR1 Gene

Other Protein References for CIR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CIR1 Gene

Domains & Families for CIR1 Gene

Gene Families for CIR1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CIR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CIR1 Gene

GenScript: Design optimal peptide antigens:
  • Recepin (CIR1_HUMAN)
genes like me logo Genes that share domains with CIR1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CIR1 Gene

Function for CIR1 Gene

Molecular function for CIR1 Gene

UniProtKB/Swiss-Prot Function:
May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.

Phenotypes From GWAS Catalog for CIR1 Gene

Gene Ontology (GO) - Molecular Function for CIR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA-binding transcription factor activity TAS 9874765
GO:0003714 transcription corepressor activity IEA,IDA 9874765
GO:0005515 protein binding IPI 9874765
GO:0019901 protein kinase binding IPI 20873783
GO:0042826 histone deacetylase binding IDA 9874765
genes like me logo Genes that share ontologies with CIR1: view
genes like me logo Genes that share phenotypes with CIR1: view

Animal Models for CIR1 Gene

MGI Knock Outs for CIR1:
  • Cir1 Cir1<tm3a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for CIR1 Gene

miRTarBase miRNAs that target CIR1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CIR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CIR1 Gene

Localization for CIR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIR1 Gene

Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CIR1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CIR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 9874765
GO:0005737 cytoplasm IEA --
GO:0005813 colocalizes_with centrosome IDA 20873783
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CIR1: view

Pathways & Interactions for CIR1 Gene

PathCards logo

SuperPathways for CIR1 Gene

SuperPathway Contained pathways
1 Notch Signaling Pathway (WikiPathways)
2 Development NOTCH1-mediated pathway for NF-KB activity modulation
.55
.55
3 Measles
genes like me logo Genes that share pathways with CIR1: view

Pathways by source for CIR1 Gene

1 BioSystems pathway for CIR1 Gene
2 GeneGo (Thomson Reuters) pathways for CIR1 Gene
  • Development Notch Signaling Pathway
  • Development NOTCH1-mediated pathway for NF-KB activity modulation
1 R&D Systems pathway for CIR1 Gene

SIGNOR curated interactions for CIR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CIR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 9874765
GO:0001701 in utero embryonic development IEA --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 9874765
genes like me logo Genes that share ontologies with CIR1: view

Drugs & Compounds for CIR1 Gene

No Compound Related Data Available

Transcripts for CIR1 Gene

mRNA/cDNA for CIR1 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CIR1

Alternative Splicing Database (ASD) splice patterns (SP) for CIR1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for CIR1 Gene

GeneLoc Exon Structure for
CIR1

Expression for CIR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CIR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CIR1 Gene

This gene is overexpressed in Cerebrospinal fluid (66.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CIR1 Gene



Protein tissue co-expression partners for CIR1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CIR1

SOURCE GeneReport for Unigene cluster for CIR1 Gene:

Hs.632531

mRNA Expression by UniProt/SwissProt for CIR1 Gene:

Q86X95-CIR1_HUMAN
Tissue specificity: Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.

Evidence on tissue expression from TISSUES for CIR1 Gene

  • Liver(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with CIR1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CIR1 Gene

Orthologs for CIR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CIR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CIR1 30 31
  • 99.7 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cir1 30 17 31
  • 91 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CIR1 30
  • 87.75 (n)
Cow
(Bos Taurus)
Mammalia CIR1 31
  • 86 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CIR1 31
  • 76 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cir1 30
  • 75.62 (n)
Oppossum
(Monodelphis domestica)
Mammalia CIR1 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CIR1 30 31
  • 75.53 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CIR1 31
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22070 30
Zebrafish
(Danio rerio)
Actinopterygii CIR1 31
  • 84 (a)
OneToOne
si:ch73-167c12.2 30
  • 76.07 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG6843 31
  • 42 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea cir-1 31
  • 30 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT1 33
Species where no ortholog for CIR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for CIR1 Gene

ENSEMBL:
Gene Tree for CIR1 (if available)
TreeFam:
Gene Tree for CIR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CIR1: view image

Paralogs for CIR1 Gene

(10) SIMAP similar genes for CIR1 Gene using alignment to 2 proteins:

  • CIR1_HUMAN
  • H3BLY3_HUMAN

Pseudogenes.org Pseudogenes for CIR1 Gene

genes like me logo Genes that share paralogs with CIR1: view

No data available for Paralogs for CIR1 Gene

Variants for CIR1 Gene

Additional dbSNP identifiers (rs#s) for CIR1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CIR1 Gene

Variant ID Type Subtype PubMed ID
esv3584179 CNV loss 25503493

Variation tolerance for CIR1 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CIR1 Gene

Human Gene Mutation Database (HGMD)
CIR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CIR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CIR1 Gene

Disorders for CIR1 Gene

No disorders were found for CIR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIR1 Gene

Publications for CIR1 Gene

  1. Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC. (PMID: 11222720) Zhang J … Hayward SD (Journal of virology 2001) 2 3 4
  2. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. (PMID: 9874765) Hsieh JJ … Hayward SD (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4
  3. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PMID: 20873783) Vaz Meirelles G … Kobarg J (Journal of proteome research 2010) 3 4
  4. NKAP is a transcriptional repressor of notch signaling and is required for T cell development. (PMID: 19409814) Pajerowski AG … Shapiro VS (Immunity 2009) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4

Products for CIR1 Gene

Sources for CIR1 Gene