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Aliases for CIP2A Gene

Aliases for CIP2A Gene

  • Cell Proliferation Regulating Inhibitor Of Protein Phosphatase 2A 2 3 5
  • KIAA1524 2 3 4
  • Cancerous Inhibitor Of Protein Phosphatase 2A 2 3
  • Cancerous Inhibitor Of PP2A 3 4
  • P90 Autoantigen 3 4
  • Protein CIP2A 3
  • P90 3

External Ids for CIP2A Gene

Previous HGNC Symbols for CIP2A Gene

  • KIAA1524

Summaries for CIP2A Gene

CIViC summary for CIP2A Gene

GeneCards Summary for CIP2A Gene

CIP2A (Cell Proliferation Regulating Inhibitor Of Protein Phosphatase 2A) is a Protein Coding gene. Among its related pathways are DNA Damage.

UniProtKB/Swiss-Prot for CIP2A Gene

  • Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.

Gene Wiki entry for CIP2A Gene

Additional gene information for CIP2A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIP2A Gene

Genomics for CIP2A Gene

GeneHancer (GH) Regulatory Elements for CIP2A Gene

Promoters and enhancers for CIP2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J108587 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 658.5 +0.3 257 3.3 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B DZIP3 CIP2A ENSG00000276763
GH03J107969 Enhancer 1 Ensembl ENCODE dbSUPER 10.4 +619.2 619248 1.7 SMAD1 NFIA NFIB ZNF195 FOXA1 NR2F2 NFIC LCORL ZNF544 ZNF350 CIP2A LINC00636 ENSG00000284828
GH03J108470 Enhancer 0.8 Ensembl ENCODE 5.6 +117.3 117304 3.6 JUN ZNF10 CEBPB CBFA2T3 EP300 SP1 ZNF335 FOSL1 JUND POLR2A DZIP3 MYH15 CIP2A RPL13P8 GC03M108465 GC03M108377
GH03J108602 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 0.4 -13.7 -13733 2.4 RFX1 POLR2A E4F1 DZIP3 MYH15 CIP2A LOC105374033
GH03J108552 Enhancer 0.5 ENCODE 0.3 +36.9 36875 0.2 CTCF ZNF654 SMC3 RAD21 MYH15 GC03P108588 CIP2A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CIP2A on UCSC Golden Path with GeneCards custom track

Genomic Locations for CIP2A Gene

Genomic Locations for CIP2A Gene
chr3:108,545,752-108,589,644
(GRCh38/hg38)
Size:
43,893 bases
Orientation:
Minus strand
chr3:108,268,716-108,308,491
(GRCh37/hg19)
Size:
39,776 bases
Orientation:
Minus strand

Genomic View for CIP2A Gene

Genes around CIP2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIP2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIP2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIP2A Gene

Proteins for CIP2A Gene

  • Protein details for CIP2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCG1-CIP2A_HUMAN
    Recommended name:
    Protein CIP2A
    Protein Accession:
    Q8TCG1
    Secondary Accessions:
    • A1L4J7
    • B9EGC3
    • Q6P4G6
    • Q8WVP8
    • Q96PI2
    • Q9H9C6
    • Q9P204

    Protein attributes for CIP2A Gene

    Size:
    905 amino acids
    Molecular mass:
    102185 Da
    Quaternary structure:
    • Homodimer (PubMed:28174209). Interacts with MYC (PubMed:17632056). Interacts with PPP2R5C; this interaction stabilizes CIP2A (PubMed:28174209). Interacts with PPP2R1A; this interaction stabilizes CIP2A (PubMed:28174209).
    Miscellaneous:
    • Antibodies against CIP2A are present in sera from many patients with gastric or prostate cancer, suggesting that it may act as a marker for such cancers.
    SequenceCaution:
    • Sequence=AAH63433.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96048.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14305.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CIP2A Gene

    Alternative splice isoforms for CIP2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CIP2A Gene

Post-translational modifications for CIP2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CIP2A Gene

Domains & Families for CIP2A Gene

Gene Families for CIP2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CIP2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CIP2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CIP2A: view

No data available for UniProtKB/Swiss-Prot for CIP2A Gene

Function for CIP2A Gene

Molecular function for CIP2A Gene

UniProtKB/Swiss-Prot Function:
Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.

Gene Ontology (GO) - Molecular Function for CIP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17632056
GO:0042803 protein homodimerization activity IDA 28174209
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with CIP2A: view
genes like me logo Genes that share phenotypes with CIP2A: view

Animal Model Products

CRISPR Products

miRNA for CIP2A Gene

miRTarBase miRNAs that target CIP2A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CIP2A

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CIP2A Gene

Localization for CIP2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIP2A Gene

Membrane; Single-pass membrane protein. Cytoplasm. Note=Slightly concentrates in the perinuclear region (PubMed:12118381). {ECO:0000269 PubMed:12118381}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CIP2A gene
Compartment Confidence
plasma membrane 5
cytosol 5
peroxisome 2
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CIP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CIP2A: view

Pathways & Interactions for CIP2A Gene

SuperPathways for CIP2A Gene

SuperPathway Contained pathways
1 DNA Damage
genes like me logo Genes that share pathways with CIP2A: view

Pathways by source for CIP2A Gene

1 Cell Signaling Technology pathway for CIP2A Gene

Gene Ontology (GO) - Biological Process for CIP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:2000179 positive regulation of neural precursor cell proliferation IEA --
genes like me logo Genes that share ontologies with CIP2A: view

No data available for SIGNOR curated interactions for CIP2A Gene

Drugs & Compounds for CIP2A Gene

No Compound Related Data Available

Transcripts for CIP2A Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CIP2A

Alternative Splicing Database (ASD) splice patterns (SP) for CIP2A Gene

No ASD Table

Relevant External Links for CIP2A Gene

GeneLoc Exon Structure for
CIP2A
ECgene alternative splicing isoforms for
CIP2A

Expression for CIP2A Gene

NURSA nuclear receptor signaling pathways regulating expression of CIP2A Gene:

CIP2A

mRNA Expression by UniProt/SwissProt for CIP2A Gene:

Q8TCG1-CIP2A_HUMAN
Tissue specificity: Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level).

Evidence on tissue expression from TISSUES for CIP2A Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with CIP2A: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CIP2A Gene

Orthologs for CIP2A Gene

This gene was present in the common ancestor of animals.

Orthologs for CIP2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1524 34 33
  • 99.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1524 34 33
  • 91.2 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1524 34 33
  • 91.05 (n)
OneToOne
mouse
(Mus musculus)
Mammalia C330027C09Rik 34 33
  • 87.17 (n)
OneToOne
Cip2a 16
rat
(Rattus norvegicus)
Mammalia RGD1310335 33
  • 86.48 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1524 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1524 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1524 34 33
  • 71.81 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1524 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1524 33
  • 67.78 (n)
Str.10282 33
zebrafish
(Danio rerio)
Actinopterygii zgc:174160 34 33
  • 56.87 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4843 33
worm
(Caenorhabditis elegans)
Secernentea B0432.7 34
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToOne
Species where no ortholog for CIP2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CIP2A Gene

ENSEMBL:
Gene Tree for CIP2A (if available)
TreeFam:
Gene Tree for CIP2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CIP2A: view image

Paralogs for CIP2A Gene

No data available for Paralogs for CIP2A Gene

Variants for CIP2A Gene

Sequence variations from dbSNP and Humsavar for CIP2A Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000014939 -- 108,558,595(-) T/C intron_variant
rs1000088108 -- 108,584,464(-) T/G intron_variant
rs1000196779 -- 108,551,504(-) A/G intron_variant
rs1000204224 -- 108,547,833(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000383855 -- 108,572,163(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CIP2A Gene

Variant ID Type Subtype PubMed ID
nsv1006774 CNV loss 25217958
nsv1011158 CNV gain 25217958
nsv1127985 CNV deletion 24896259
nsv524016 CNV loss 19592680
nsv829658 CNV gain 17160897
nsv954375 CNV deletion 24416366

Variation tolerance for CIP2A Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.03; 87.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CIP2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CIP2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIP2A Gene

Disorders for CIP2A Gene

Additional Disease Information for CIP2A

No disorders were found for CIP2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIP2A Gene

Publications for CIP2A Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56. (PMID: 28174209) Wang J … Westermarck J (EMBO reports 2017) 3 4 58
  3. Cancerous inhibitor of protein phosphatase 2A promotes premature chromosome segregation and aneuploidy in prostate cancer cells through association with shugoshin. (PMID: 25736928) Pallai R … Rice LM (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015) 2 3 58
  4. Cancerous inhibitor of protein phosphatase 2A (CIP2A) protein is involved in centrosome separation through the regulation of NIMA (never in mitosis gene A)-related kinase 2 (NEK2) protein activity. (PMID: 24214971) Jeong AL … Yang Y (The Journal of biological chemistry 2014) 2 3 58
  5. CIP2A inhibits PP2A in human malignancies. (PMID: 17632056) Junttila MR … Westermarck J (Cell 2007) 3 4 58

Products for CIP2A Gene

Sources for CIP2A Gene

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