Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CINP Gene

Aliases for CINP Gene

  • Cyclin Dependent Kinase 2 Interacting Protein 2 3 5
  • CDK2-Interacting Protein 3 4
  • Cyclin-Dependent Kinase 2-Interacting Protein 3

External Ids for CINP Gene

Previous GeneCards Identifiers for CINP Gene

  • GC14M100200
  • GC14M096630
  • GC14M100798
  • GC14M101878
  • GC14M102814
  • GC14M082991
  • GC14M102808

Summaries for CINP Gene

Entrez Gene Summary for CINP Gene

  • The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for CINP Gene

CINP (Cyclin Dependent Kinase 2 Interacting Protein) is a Protein Coding gene. Diseases associated with CINP include Dysthymic Disorder and Cervix Uteri Carcinoma In Situ.

UniProtKB/Swiss-Prot for CINP Gene

  • Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.

Additional gene information for CINP Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CINP Gene

Genomics for CINP Gene

GeneHancer (GH) Regulatory Elements for CINP Gene

Promoters and enhancers for CINP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J102361 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 655.5 0.0 -41 2.6 PKNOX1 ATF1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 IRF4 ZNF48 YY1 CINP TECPR2 RCOR1 WDR20 ZNF839
GH14J102315 Promoter/Enhancer 2 Ensembl ENCODE dbSUPER 17.7 +43.1 43125 7.7 MLX DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1 RCOR1 ENSG00000272444 WDR20 ENSG00000271780 CINP TECPR2 CDC42BPB ZNF839 DYNC1H1 ENSG00000258959
GH14J102507 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 -146.9 -146942 4.9 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 SLC30A9 SP3 SP5 NFYC KAT8 ANKRD9 LOC105370679 RCOR1 CINP TECPR2 ZNF839 AMN
GH14J102522 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -163.1 -163078 6 MLX YBX1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC GLIS1 RCOR2 RCOR1 WDR20 TECPR2 MOK ANKRD9 ZNF839 RPL23AP11 CDC42BPB TRAF3 RNU6-244P
GH14J102313 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.3 +48.5 48515 1.6 CLOCK ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF213 ZNF207 ZNF143 WDR20 ZNF839 CINP TECPR2 ENSG00000271780 HSP90AA1 TRI-AAT5-4 MOK
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CINP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CINP gene promoter:
  • HEN1
  • Olf-1
  • LCR-F1
  • CUTL1
  • Pax-4a
  • POU2F1a
  • POU2F1
  • HSF2
  • AhR
  • GATA-1

Genomic Locations for CINP Gene

Genomic Locations for CINP Gene
21,815 bases
Minus strand
20,298 bases
Minus strand

Genomic View for CINP Gene

Genes around CINP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CINP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CINP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CINP Gene

Proteins for CINP Gene

  • Protein details for CINP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin-dependent kinase 2-interacting protein
    Protein Accession:
    Secondary Accessions:
    • F5H7P3
    • F5H8A7
    • Q9NPF9

    Protein attributes for CINP Gene

    212 amino acids
    Molecular mass:
    24324 Da
    Quaternary structure:
    • Homodimer. Interacts with CDK2 and CDC7. Interacts with the components of the replication complex, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 and with ORC2-containing complexes. Interacts with ATRIP. Interacts with CEP152.
    • Sequence=BU174070; Type=Frameshift; Positions=183, 197; Evidence={ECO:0000305};

    Alternative splice isoforms for CINP Gene


neXtProt entry for CINP Gene

Post-translational modifications for CINP Gene

Other Protein References for CINP Gene

No data available for DME Specific Peptides for CINP Gene

Domains & Families for CINP Gene

Gene Families for CINP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CINP Gene


Suggested Antigen Peptide Sequences for CINP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CINP family.
  • Belongs to the CINP family.
genes like me logo Genes that share domains with CINP: view

Function for CINP Gene

Molecular function for CINP Gene

UniProtKB/Swiss-Prot Function:
Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.

Phenotypes From GWAS Catalog for CINP Gene

Gene Ontology (GO) - Molecular Function for CINP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with CINP: view
genes like me logo Genes that share phenotypes with CINP: view

Animal Models for CINP Gene

MGI Knock Outs for CINP:
  • Cinp Cinp<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CINP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CINP Gene

Localization for CINP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CINP Gene

Nucleus. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CINP gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CINP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CINP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CINP Gene

Pathways & Interactions for CINP Gene

No Data Available

Gene Ontology (GO) - Biological Process for CINP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007049 cell cycle IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with CINP: view

No data available for Pathways by source and SIGNOR curated interactions for CINP Gene

Drugs & Compounds for CINP Gene

(3) Drugs for CINP Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Quercetin Experimental, Investigational Nutra Antitumor agent, Non-selective PI 3-kinase inhibitor 42
Antioxidants Pharma 3252
Protective Agents Pharma 7926

(2) Additional Compounds for CINP Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • beta-Hydroxy stearyl-CoA
  • 3-Hydroxyoctadecanoyl-CoA
  • beta-Hydroxystearoyl-CoA
  • Behenoyl-CoA
  • Behenoyl-coenzyme A
genes like me logo Genes that share compounds with CINP: view

Transcripts for CINP Gene

mRNA/cDNA for CINP Gene

Unigene Clusters for CINP Gene

Cyclin-dependent kinase 2 interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CINP

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CINP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - -

Relevant External Links for CINP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CINP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CINP Gene

Protein differential expression in normal tissues from HIPED for CINP Gene

This gene is overexpressed in Retina (47.9), CD8 Tcells (14.5), and Placenta (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CINP Gene

Protein tissue co-expression partners for CINP Gene

NURSA nuclear receptor signaling pathways regulating expression of CINP Gene:


SOURCE GeneReport for Unigene cluster for CINP Gene:


Evidence on tissue expression from TISSUES for CINP Gene

  • Nervous system(4.7)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with CINP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CINP Gene

Orthologs for CINP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CINP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CINP 34 33
  • 99.21 (n)
(Bos Taurus)
Mammalia CINP 34 33
  • 82.86 (n)
(Canis familiaris)
Mammalia CINP 34 33
  • 82.39 (n)
(Mus musculus)
Mammalia Cinp 16 34 33
  • 79.09 (n)
(Rattus norvegicus)
Mammalia Cinp 33
  • 78.62 (n)
(Monodelphis domestica)
Mammalia CINP 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia CINP 34
  • 63 (a)
(Gallus gallus)
Aves CINP 34 33
  • 67.31 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cinp 33
  • 59.97 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15051 33
(Danio rerio)
Actinopterygii LOC100003640 33
  • 57.43 (n)
cinp 34
  • 48 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6870 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
Species where no ortholog for CINP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CINP Gene

Gene Tree for CINP (if available)
Gene Tree for CINP (if available)
Evolutionary constrained regions (ECRs) for CINP: view image

Paralogs for CINP Gene

No data available for Paralogs for CINP Gene

Variants for CINP Gene

Sequence variations from dbSNP and Humsavar for CINP Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1060499740 likely-pathogenic, Intellectual disability, Microcephaly, Seizures 102,348,559(-) A/C 3_prime_UTR_variant, non_coding_transcript_variant, stop_lost, terminator_codon_variant
VAR_039980 A colorectal cancer sample p.Asp177Asn
rs1000006467 -- 102,354,305(-) C/T intron_variant
rs1000050251 -- 102,354,939(-) C/G/T intron_variant
rs1000094381 -- 102,341,375(-) T/C genic_downstream_transcript_variant, non_coding_transcript_variant

Variation tolerance for CINP Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.63; 82.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CINP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CINP Gene

Disorders for CINP Gene

MalaCards: The human disease database

(3) MalaCards diseases for CINP Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
dysthymic disorder
  • dysthymia
cervix uteri carcinoma in situ
  • carcinoma in situ of cervix
seckel syndrome
  • sckl
- elite association - COSMIC cancer census association via MalaCards
Search CINP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CINP

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CINP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CINP Gene

Publications for CINP Gene

  1. A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes. (PMID: 16082200) Grishina I … Lattes B (Cell cycle (Georgetown, Tex.) 2005) 2 3 4 58
  2. CEP152 is a genome maintenance protein disrupted in Seckel syndrome. (PMID: 21131973) Kalay E … Wollnik B (Nature genetics 2011) 3 4 58
  3. Functional genomic screens identify CINP as a genome maintenance protein. (PMID: 19889979) Lovejoy CA … Cortez D (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CINP Gene

Sources for CINP Gene

Loading form....