The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signali... See more...

Aliases for CINP Gene

Aliases for CINP Gene

  • Cyclin Dependent Kinase 2 Interacting Protein 2 3 5
  • Cyclin-Dependent Kinase 2-Interacting Protein 3 4
  • CDK2-Interacting Protein 3 4
  • MGC849 2
  • CINP 5

External Ids for CINP Gene

Previous GeneCards Identifiers for CINP Gene

  • GC14M100200
  • GC14M096630
  • GC14M100798
  • GC14M101878
  • GC14M102814
  • GC14M082991
  • GC14M102808

Summaries for CINP Gene

Entrez Gene Summary for CINP Gene

  • The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for CINP Gene

CINP (Cyclin Dependent Kinase 2 Interacting Protein) is a Protein Coding gene. Diseases associated with CINP include Paraneoplastic Polyneuropathy and Seckel Syndrome.

UniProtKB/Swiss-Prot Summary for CINP Gene

  • Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CINP Gene

Genomics for CINP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CINP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CINP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CINP

Top Transcription factor binding sites by QIAGEN in the CINP gene promoter:
  • AhR
  • CUTL1
  • GATA-1
  • HEN1
  • HSF2
  • LCR-F1
  • Olf-1
  • Pax-4a
  • POU2F1
  • POU2F1a

Genomic Locations for CINP Gene

Genomic Locations for CINP Gene
chr14:102,341,102-102,362,916
(GRCh38/hg38)
Size:
21,815 bases
Orientation:
Minus strand
chr14:102,808,956-102,829,253
(GRCh37/hg19)
Size:
20,298 bases
Orientation:
Minus strand

Genomic View for CINP Gene

Genes around CINP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CINP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CINP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CINP Gene

Proteins for CINP Gene

  • Protein details for CINP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW66-CINP_HUMAN
    Recommended name:
    Cyclin-dependent kinase 2-interacting protein
    Protein Accession:
    Q9BW66
    Secondary Accessions:
    • F5H7P3
    • F5H8A7
    • Q9NPF9

    Protein attributes for CINP Gene

    Size:
    212 amino acids
    Molecular mass:
    24324 Da
    Quaternary structure:
    • Homodimer. Interacts with CDK2 and CDC7. Interacts with the components of the replication complex, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 and with ORC2-containing complexes. Interacts with ATRIP. Interacts with CEP152.
    SequenceCaution:
    • Sequence=BU174070; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for CINP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CINP Gene

Post-translational modifications for CINP Gene

Other Protein References for CINP Gene

No data available for DME Specific Peptides for CINP Gene

Domains & Families for CINP Gene

Gene Families for CINP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CINP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CINP Gene

GenScript: Design optimal peptide antigens:
  • Cyclin-dependent kinase 2-interacting protein (CINP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BW66

UniProtKB/Swiss-Prot:

CINP_HUMAN :
  • Belongs to the CINP family.
Family:
  • Belongs to the CINP family.
genes like me logo Genes that share domains with CINP: view

Function for CINP Gene

Molecular function for CINP Gene

UniProtKB/Swiss-Prot Function:
Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.

Phenotypes From GWAS Catalog for CINP Gene

Gene Ontology (GO) - Molecular Function for CINP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with CINP: view
genes like me logo Genes that share phenotypes with CINP: view

Animal Models for CINP Gene

MGI Knock Outs for CINP:
  • Cinp Cinp<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CINP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CINP Gene

Localization for CINP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CINP Gene

Nucleus. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CINP gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CINP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CINP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CINP Gene

Pathways & Interactions for CINP Gene

PathCards logo

SuperPathways for CINP Gene

No Data Available

Gene Ontology (GO) - Biological Process for CINP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007049 cell cycle IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with CINP: view

No data available for Pathways by source and SIGNOR curated interactions for CINP Gene

Drugs & Compounds for CINP Gene

(3) Drugs for CINP Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Quercetin Experimental, Investigational Pharma Antitumor agent, Non-selective PI 3-kinase inhibitor 54
Antioxidants Pharma 3447
Protective Agents Pharma 7501

(2) Additional Compounds for CINP Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-hydroxyoctadecanoyl-CoA
  • beta-Hydroxy stearyl-CoA
  • 3-Hydroxyoctadecanoyl-CoA
  • beta-Hydroxystearoyl-CoA
42578-91-6
Docosanoyl-CoA
  • Behenoyl-CoA
  • Behenoyl-coenzyme A
genes like me logo Genes that share compounds with CINP: view

Transcripts for CINP Gene

mRNA/cDNA for CINP Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CINP

Alternative Splicing Database (ASD) splice patterns (SP) for CINP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7:
SP8:

Relevant External Links for CINP Gene

GeneLoc Exon Structure for
CINP

Expression for CINP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CINP Gene

Protein differential expression in normal tissues from HIPED for CINP Gene

This gene is overexpressed in Retina (47.9), CD8 Tcells (14.5), and Placenta (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CINP Gene



Protein tissue co-expression partners for CINP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CINP

SOURCE GeneReport for Unigene cluster for CINP Gene:

Hs.129634

Evidence on tissue expression from TISSUES for CINP Gene

  • Nervous system(4.7)
  • Skin(4.5)
genes like me logo Genes that share expression patterns with CINP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CINP Gene

Orthologs for CINP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CINP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CINP 30 31
  • 99.21 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CINP 30 31
  • 82.86 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CINP 30 31
  • 82.39 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cinp 30 17 31
  • 79.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cinp 30
  • 78.62 (n)
Oppossum
(Monodelphis domestica)
Mammalia CINP 31
  • 68 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CINP 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CINP 30 31
  • 67.31 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cinp 30
  • 59.97 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15051 30
Zebrafish
(Danio rerio)
Actinopterygii LOC100003640 30
  • 57.43 (n)
cinp 31
  • 48 (a)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6870 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 29 (a)
OneToOne
Species where no ortholog for CINP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CINP Gene

ENSEMBL:
Gene Tree for CINP (if available)
TreeFam:
Gene Tree for CINP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CINP: view image

Paralogs for CINP Gene

No data available for Paralogs for CINP Gene

Variants for CINP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CINP Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs1060499740 Likely Pathogenic: Microcephaly; Intellectual disability; Seizures 102,348,559(-) A/C STOP_LOST,THREE_PRIME_UTR_VARIANT
VAR_039980 A colorectal cancer sample p.Asp177Asn
rs7011 - p.Arg164His

Additional dbSNP identifiers (rs#s) for CINP Gene

Variation tolerance for CINP Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.63; 82.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CINP Gene

Human Gene Mutation Database (HGMD)
CINP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CINP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CINP Gene

Disorders for CINP Gene

MalaCards: The human disease database

(5) MalaCards diseases for CINP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
paraneoplastic polyneuropathy
seckel syndrome
  • sckl
complex partial epilepsy
  • complex partial epileptic seizure
inflammatory and toxic neuropathy
microcephaly
  • microcephalus
- elite association - COSMIC cancer census association via MalaCards
Search CINP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CINP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CINP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CINP Gene

Publications for CINP Gene

  1. A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes. (PMID: 16082200) Grishina I … Lattes B (Cell cycle (Georgetown, Tex.) 2005) 2 3 4
  2. CEP152 is a genome maintenance protein disrupted in Seckel syndrome. (PMID: 21131973) Kalay E … Wollnik B (Nature genetics 2011) 3 4
  3. Functional genomic screens identify CINP as a genome maintenance protein. (PMID: 19889979) Lovejoy CA … Cortez D (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for CINP Gene

Sources for CINP Gene