Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CILP2 Gene

Aliases for CILP2 Gene

  • Cartilage Intermediate Layer Protein 2 2 3 5
  • CILP-2 3 4
  • Cartilage Intermediate Layer Protein-Like Protein 2 3
  • CLIP-2 3

External Ids for CILP2 Gene

Previous GeneCards Identifiers for CILP2 Gene

  • GC19P019473
  • GC19P019511
  • GC19P019649
  • GC19P019211

Summaries for CILP2 Gene

GeneCards Summary for CILP2 Gene

CILP2 (Cartilage Intermediate Layer Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and nucleotide diphosphatase activity. An important paralog of this gene is CILP.

UniProtKB/Swiss-Prot for CILP2 Gene

  • May play a role in cartilage scaffolding.

Additional gene information for CILP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CILP2 Gene

Genomics for CILP2 Gene

GeneHancer (GH) Regulatory Elements for CILP2 Gene

Promoters and enhancers for CILP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I019536 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 550.8 -0.2 -156 2.6 KLF1 ZNF223 KLF17 ZNF76 ZIC2 ZNF121 ZFHX2 GLIS2 POLR2A PATZ1 CILP2 GC19M019535 NDUFA13 GATAD2A YJEFN3
GH19I020077 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 4.7 +542.5 542466 6.8 TFAP4 MXI1 PKNOX1 USF1 SAP130 ARID4B MAX ZSCAN9 YY1 GATAD1 ZNF90 LOC100419301 ZNF682 BNIP3P15 CILP2 MEF2B ZNF506 BNIP3P14
GH19I019539 Enhancer 0.9 Ensembl ENCODE 0.8 +2.6 2575 2.5 HDGF CTCF KLF1 PKNOX1 USF1 CTBP1 POLR2A EGR1 VEZF1 KLF8 NDUFA13 GATAD2A CILP2 GC19M019560
GH19I019550 Enhancer 0.8 ENCODE 0.4 +12.4 12365 1.1 NCOA3 PKNOX1 ESRRA NFIB NEUROD1 SIN3A ZIC2 RFX5 ZKSCAN1 ZEB1 GC19M019560 CILP2
GH19I019552 Enhancer 0.7 ENCODE 0.4 +11.7 11719 0.2 NCOA3 PKNOX1 ESRRA NFIB NEUROD1 SIN3A RFX5 ZKSCAN1 GATA3 CTBP1 GC19M019560 CILP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CILP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CILP2 gene promoter:

Genomic Locations for CILP2 Gene

Genomic Locations for CILP2 Gene
8,412 bases
Plus strand

Genomic View for CILP2 Gene

Genes around CILP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CILP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CILP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CILP2 Gene

Proteins for CILP2 Gene

  • Protein details for CILP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cartilage intermediate layer protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6NV88
    • Q8N4A6
    • Q8WV21

    Protein attributes for CILP2 Gene

    1156 amino acids
    Molecular mass:
    126291 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CILP2 Gene

Post-translational modifications for CILP2 Gene

  • May be cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion.
  • Glycosylation at Thr236, posLast=276276, Asn308, and posLast=329329
  • Modification sites at PhosphoSitePlus

Other Protein References for CILP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CILP2 Gene

Domains & Families for CILP2 Gene

Gene Families for CILP2 Gene

Suggested Antigen Peptide Sequences for CILP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CILP2: view

No data available for UniProtKB/Swiss-Prot for CILP2 Gene

Function for CILP2 Gene

Molecular function for CILP2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cartilage scaffolding.

Phenotypes From GWAS Catalog for CILP2 Gene

Gene Ontology (GO) - Molecular Function for CILP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004035 NOT alkaline phosphatase activity IDA 12746903
GO:0004551 NOT nucleotide diphosphatase activity IDA 12746903
genes like me logo Genes that share ontologies with CILP2: view
genes like me logo Genes that share phenotypes with CILP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CILP2 Gene

Localization for CILP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CILP2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CILP2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CILP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with CILP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CILP2 Gene

Pathways & Interactions for CILP2 Gene

SuperPathways for CILP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CILP2 Gene


No data available for Pathways by source and SIGNOR curated interactions for CILP2 Gene

Drugs & Compounds for CILP2 Gene

No Compound Related Data Available

Transcripts for CILP2 Gene

mRNA/cDNA for CILP2 Gene

Unigene Clusters for CILP2 Gene

Cartilage intermediate layer protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CILP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - -
SP2: - - -
SP4: -

Relevant External Links for CILP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CILP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CILP2 Gene

mRNA differential expression in normal tissues according to GTEx for CILP2 Gene

This gene is overexpressed in Testis (x14.3).

Protein differential expression in normal tissues from HIPED for CILP2 Gene

This gene is overexpressed in Urine (43.5), Serum (15.2), and Heart (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CILP2 Gene

Protein tissue co-expression partners for CILP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CILP2 Gene:


SOURCE GeneReport for Unigene cluster for CILP2 Gene:


mRNA Expression by UniProt/SwissProt for CILP2 Gene:

Tissue specificity: Expressed in articular chondrocytes but not in knee meniscal cartilage cells (PubMed:12746903). Localizes to the intermediate to deep zone of articular cartilage (PubMed:21880736).

Evidence on tissue expression from TISSUES for CILP2 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with CILP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CILP2 Gene

Orthologs for CILP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CILP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CILP2 33 34
  • 99.39 (n)
(Canis familiaris)
Mammalia CILP2 33 34
  • 87.2 (n)
(Bos Taurus)
Mammalia CILP2 33 34
  • 85.93 (n)
(Rattus norvegicus)
Mammalia Cilp2 33
  • 78.36 (n)
(Mus musculus)
Mammalia Cilp2 33 16 34
  • 77.64 (n)
(Ornithorhynchus anatinus)
Mammalia CILP2 34
  • 68 (a)
(Monodelphis domestica)
Mammalia CILP2 34
  • 64 (a)
(Gallus gallus)
Aves CILP2 33 34
  • 69.99 (n)
(Anolis carolinensis)
Reptilia CILP2 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cilp2 33
  • 56.8 (n)
(Danio rerio)
Actinopterygii cilp2 33 34
  • 57.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
Species where no ortholog for CILP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CILP2 Gene

Gene Tree for CILP2 (if available)
Gene Tree for CILP2 (if available)

Paralogs for CILP2 Gene

Paralogs for CILP2 Gene

(1) SIMAP similar genes for CILP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CILP2: view

Variants for CILP2 Gene

Sequence variations from dbSNP and Humsavar for CILP2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1001042490 -- 19,541,920(+) A/G intron_variant
rs1001434526 -- 19,537,832(+) A/G upstream_transcript_variant
rs1001830420 -- 19,536,738(+) G/A upstream_transcript_variant
rs1002156629 -- 19,537,251(+) G/C upstream_transcript_variant
rs1002589236 -- 19,541,546(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CILP2 Gene

Variant ID Type Subtype PubMed ID
nsv509723 CNV insertion 20534489
nsv952426 CNV deletion 24416366

Variation tolerance for CILP2 Gene

Residual Variation Intolerance Score: 16.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CILP2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CILP2 Gene

Disorders for CILP2 Gene

Additional Disease Information for CILP2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CILP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CILP2 Gene

Publications for CILP2 Gene

  1. One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist. (PMID: 12746903) Johnson K … Terkeltaub R (Arthritis and rheumatism 2003) 3 4 22 58
  2. Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis. (PMID: 21880736) Bernardo BC … Bateman JF (The Journal of biological chemistry 2011) 3 4 58
  3. Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. (PMID: 20570916) Keebler ME … Kathiresan S (Circulation. Cardiovascular genetics 2010) 3 44 58
  4. Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population. (PMID: 18987386) Tai ES … Seielstad M (Journal of lipid research 2009) 3 44 58
  5. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S … Cupples LA (Nature genetics 2009) 3 44 58

Products for CILP2 Gene

Sources for CILP2 Gene

Loading form....