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Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]
CILK1 (Ciliogenesis Associated Kinase 1) is a Protein Coding gene. Diseases associated with CILK1 include Endocrine-Cerebroosteodysplasia and Epilepsy, Juvenile Myoclonic 10. An important paralog of this gene is MAK.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000287 | magnesium ion binding | IDA | 10699974 |
GO:0004672 | protein kinase activity | IDA | 19185282 |
GO:0004674 | protein serine/threonine kinase activity | IBA,IDA | 10699974 |
GO:0004707 | MAP kinase activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001650 | fibrillar center | IDA | -- |
GO:0005634 | nucleus | IBA,ISS | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | IEA | -- |
GO:0005856 | cytoskeleton | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006468 | protein phosphorylation | IDA | 10699974 |
GO:0007165 | signal transduction | TAS | 10699974 |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0010468 | regulation of gene expression | IBA | 21873635 |
GO:0016310 | phosphorylation | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
Beta-D-Glucose | Experimental | Pharma | Target | 0 | ||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ICK 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ICK 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ICK 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ICK 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ick 30 31 |
|
OneToOne | |
Cilk1 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Ick 30 |
|
||
Chicken (Gallus gallus) |
Aves | ICK 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ICK 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ick 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG42366 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | dyf-5 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IME2 31 33 33 |
|
OneToMany | |
Barley (Hordeum vulgare) |
Liliopsida | Hv.1455 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.8284 30 |
|
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
708986 | Likely Benign: not provided | 53,009,539(-) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
725806 | Likely Benign: not provided | 53,011,845(-) | T/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
728070 | Likely Benign: not provided | 53,012,213(-) | G/C | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
729148 | Benign: not provided | 53,009,452(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
734127 | Benign/Likely Benign: not specified; not provided | 53,016,248(-) | A/G | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
endocrine-cerebroosteodysplasia |
|
|
epilepsy, juvenile myoclonic 10 |
|
|
epilepsy, myoclonic juvenile |
|
|
epilepsy |
|
|
seizure disorder |
|
|