This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mic... See more...

Aliases for CIDEA Gene

Aliases for CIDEA Gene

  • Cell Death Inducing DFFA Like Effector A 2 3 5
  • Cell Death-Inducing DFFA-Like Effector A 2 4
  • Cell Death Activator CIDE-A 3 4
  • CIDE-A 2 3
  • CIDEA 5

External Ids for CIDEA Gene

Previous GeneCards Identifiers for CIDEA Gene

  • GC00U990051
  • GC18P012311
  • GC18P012244
  • GC18P012208

Summaries for CIDEA Gene

Entrez Gene Summary for CIDEA Gene

  • This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010]

GeneCards Summary for CIDEA Gene

CIDEA (Cell Death Inducing DFFA Like Effector A) is a Protein Coding gene. Diseases associated with CIDEA include Body Mass Index Quantitative Trait Locus 11 and Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Differentiation of white and brown adipocyte and Metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is CIDEC.

UniProtKB/Swiss-Prot Summary for CIDEA Gene

  • Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.

Gene Wiki entry for CIDEA Gene

Additional gene information for CIDEA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CIDEA Gene

Genomics for CIDEA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CIDEA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J012259 Promoter/Enhancer 1.1 Ensembl ENCODE dbSUPER 616 +1.4 1390 1.9 FOXA1 PRDM1 EZH2 ZNF600 SCRT2 ZFHX2 ZNF335 FOS JUND EGR2 CIDEA LOC105371996 HSALNG0120096 TUBB6 RNU6-170P ENSG00000267733 PRELID3A ENSG00000267199 lnc-CIDEA-4
GH18J012255 Promoter/Enhancer 1 EPDnew Ensembl dbSUPER 600.7 -0.1 -60 0.2 EZH2 EGR1 CIDEA LOC105371996 HSALNG0120096 PPIAP56 lnc-CIDEA-5 ANKRD62
GH18J012256 Promoter/Enhancer 0.6 EPDnew dbSUPER 600.7 +0.3 331 0.1 EZH2 CIDEA LOC105371996 HSALNG0120096 TUBB6
GH18J012253 Enhancer 0.5 FANTOM5 dbSUPER 600.7 -1.2 -1169 0.1 EZH2 CIDEA LOC105371996 HSALNG0120096 SPIRE1 PPIAP56 lnc-CIDEA-5 ANKRD62
GH18J012277 Promoter/Enhancer 1.9 VISTA Ensembl ENCODE CraniofacialAtlas dbSUPER 4.8 +26.5 26510 6.8 GATAD2A CTCF TFE3 IKZF1 JUND PRDM1 ZIC2 REST POLR2A DPF2 ENSG00000280302 lnc-AFG3L2-5 TUBB6 ENSG00000267199 PRELID3A ENSG00000267069 CIDEA lnc-CIDEA-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CIDEA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CIDEA

Top Transcription factor binding sites by QIAGEN in the CIDEA gene promoter:
  • AP-1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for CIDEA Gene

Genomic Locations for CIDEA Gene
chr18:12,254,361-12,277,595
(GRCh38/hg38)
Size:
23,235 bases
Orientation:
Plus strand
chr18:12,254,318-12,277,594
(GRCh37/hg19)
Size:
23,277 bases
Orientation:
Plus strand

Genomic View for CIDEA Gene

Genes around CIDEA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIDEA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIDEA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIDEA Gene

Proteins for CIDEA Gene

  • Protein details for CIDEA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60543-CIDEA_HUMAN
    Recommended name:
    Cell death activator CIDE-A
    Protein Accession:
    O60543
    Secondary Accessions:
    • B0YIY7
    • Q6UPR7

    Protein attributes for CIDEA Gene

    Size:
    219 amino acids
    Molecular mass:
    24687 Da
    Quaternary structure:
    • Directly interacts with CEBPB (By similarity). Interacts with CIDEC.

    Three dimensional structures from OCA and Proteopedia for CIDEA Gene

neXtProt entry for CIDEA Gene

Post-translational modifications for CIDEA Gene

No Post-translational modifications

Other Protein References for CIDEA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CIDEA Gene

Domains & Families for CIDEA Gene

Gene Families for CIDEA Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for CIDEA Gene

InterPro:
Blocks:
  • Caspase-activated nuclease CIDE-N
ProtoNet:

Suggested Antigen Peptide Sequences for CIDEA Gene

GenScript: Design optimal peptide antigens:
  • Cell death-inducing DFFA-like effector A (CIDEA_HUMAN)
  • Cell death-inducing DFFA-like effector a (Q8N5P9_HUMAN)
genes like me logo Genes that share domains with CIDEA: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CIDEA Gene

Function for CIDEA Gene

Molecular function for CIDEA Gene

UniProtKB/Swiss-Prot Function:
Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.

Phenotypes From GWAS Catalog for CIDEA Gene

Gene Ontology (GO) - Molecular Function for CIDEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IEA,ISS 17080483
genes like me logo Genes that share ontologies with CIDEA: view
genes like me logo Genes that share phenotypes with CIDEA: view

Animal Models for CIDEA Gene

MGI Knock Outs for CIDEA:
  • Cidea Cidea<tm1Pli>
  • Cidea Cidea<tm1b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for CIDEA

CRISPR Products

miRNA for CIDEA Gene

miRTarBase miRNAs that target CIDEA

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CIDEA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CIDEA Gene

Localization for CIDEA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIDEA Gene

Lipid droplet. Nucleus. Note=Enriched at lipid droplet contact sites. Has been shown to localize to mitochondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (By similarity). These data could not be confirmed (PubMed:18509062). {ECO:0000250, ECO:0000269 PubMed:18509062}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CIDEA gene
Compartment Confidence
cytosol 5
mitochondrion 4
nucleus 4
extracellular 2
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
plasma membrane 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CIDEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS 17080483
GO:0005737 cytoplasm IEA,ISS 17080483
GO:0005739 mitochondrion IEA,ISS --
GO:0005740 mitochondrial envelope IEA,ISS --
GO:0005811 colocalizes_with lipid droplet IDA 18509062
genes like me logo Genes that share ontologies with CIDEA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CIDEA Gene

Pathways & Interactions for CIDEA Gene

genes like me logo Genes that share pathways with CIDEA: view

Pathways by source for CIDEA Gene

Gene Ontology (GO) - Biological Process for CIDEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IEA,ISS --
GO:0006629 lipid metabolic process IEA,ISS --
GO:0006915 apoptotic process IEA --
GO:0008219 cell death ISS 17080483
GO:0010890 positive regulation of sequestering of triglyceride IEA,ISS 18509062
genes like me logo Genes that share ontologies with CIDEA: view

No data available for SIGNOR curated interactions for CIDEA Gene

Drugs & Compounds for CIDEA Gene

No Compound Related Data Available

Transcripts for CIDEA Gene

mRNA/cDNA for CIDEA Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CIDEA

Alternative Splicing Database (ASD) splice patterns (SP) for CIDEA Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1:
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for CIDEA Gene

GeneLoc Exon Structure for
CIDEA

Expression for CIDEA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CIDEA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CIDEA Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x19.2), Adipose - Subcutaneous (x12.6), and Breast - Mammary Tissue (x9.1).

Protein differential expression in normal tissues from HIPED for CIDEA Gene

This gene is overexpressed in Milk (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CIDEA Gene



Protein tissue co-expression partners for CIDEA Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CIDEA

SOURCE GeneReport for Unigene cluster for CIDEA Gene:

Hs.249129

mRNA Expression by UniProt/SwissProt for CIDEA Gene:

O60543-CIDEA_HUMAN
Tissue specificity: Expressed in omental and subcutaneous adipose tissue (at protein level).

Evidence on tissue expression from TISSUES for CIDEA Gene

  • Nervous system(4.4)
  • Liver(2.6)
  • Skin(2.5)
  • Blood(2.4)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with CIDEA: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CIDEA Gene

Orthologs for CIDEA Gene

This gene was present in the common ancestor of chordates.

Orthologs for CIDEA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CIDEA 30
  • 99.09 (n)
Cow
(Bos Taurus)
Mammalia -- 31
  • 87 (a)
OneToMany
CIDEA 30 31
  • 80.65 (n)
OneToMany
Mouse
(Mus musculus)
Mammalia Cidea 30 17 31
  • 82.41 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CIDEA 30 31
  • 82.11 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cidea 30
  • 81.62 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 77 (a)
OneToMany
-- 31
  • 66 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia CIDEA 31
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CIDEA 30 31
  • 66.04 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cidea 30
  • 60.51 (n)
Zebrafish
(Danio rerio)
Actinopterygii cidea 30 31
  • 60.36 (n)
OneToOne
-- 30
Species where no ortholog for CIDEA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CIDEA Gene

ENSEMBL:
Gene Tree for CIDEA (if available)
TreeFam:
Gene Tree for CIDEA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CIDEA: view image

Paralogs for CIDEA Gene

Paralogs for CIDEA Gene

(2) SIMAP similar genes for CIDEA Gene using alignment to 3 proteins:

  • CIDEA_HUMAN
  • E5RJ03_HUMAN
  • Q8N5P9_HUMAN
genes like me logo Genes that share paralogs with CIDEA: view

Variants for CIDEA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CIDEA Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
731469 Benign: not provided 12,264,400(+) T/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs11545881 - p.Val115Phe

Additional dbSNP identifiers (rs#s) for CIDEA Gene

Structural Variations from Database of Genomic Variants (DGV) for CIDEA Gene

Variant ID Type Subtype PubMed ID
esv2758714 CNV loss 17122850
esv3641830 CNV loss 21293372
esv3641831 CNV loss 21293372
nsv1063125 CNV loss 25217958
nsv576496 CNV gain 21841781

Variation tolerance for CIDEA Gene

Residual Variation Intolerance Score: 67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CIDEA Gene

Human Gene Mutation Database (HGMD)
CIDEA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CIDEA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIDEA Gene

Disorders for CIDEA Gene

MalaCards: The human disease database

(2) MalaCards diseases for CIDEA Gene - From: DISEASES and Novoseek

- elite association - COSMIC cancer census association via MalaCards
Search CIDEA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CIDEA_HUMAN
  • Note=In omental and subcutaneous adipose tissue of obese patients matched for BMI, expression levels correlate with insulin sensitivity. Expression is increased 5-6 fold in the group of patients with high insulin sensitivity, compared to the insulin-resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle. {ECO:0000269 PubMed:18509062}.

Additional Disease Information for CIDEA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CIDEA: view

No data available for Genatlas for CIDEA Gene

Publications for CIDEA Gene

  1. Cidea is associated with lipid droplets and insulin sensitivity in humans. (PMID: 18509062) Puri V … Czech MP (Proceedings of the National Academy of Sciences of the United States of America 2008) 2 3 4
  2. The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects. (PMID: 16186410) Dahlman I … Arner P (Diabetes 2005) 3 23 41
  3. CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. (PMID: 9564035) Inohara N … Núñez G (The EMBO journal 1998) 2 3 4
  4. Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA. (PMID: 19843876) Liu K … Smas CM (American journal of physiology. Endocrinology and metabolism 2009) 3 4
  5. Cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G-->T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men. (PMID: 18328351) Zhang L … Muramatsu M (Metabolism: clinical and experimental 2008) 3 41

Products for CIDEA Gene

Sources for CIDEA Gene