Aliases for CIBAR2 Gene

Aliases for CIBAR2 Gene

  • CBY1 Interacting BAR Domain Containing 2 2 3
  • Family With Sequence Similarity 92 Member B 2 3 5
  • FAM92B 3 4 5
  • CBY1-Interacting BAR Domain-Containing Protein 2 3 4
  • Protein FAM92B 3 4
  • FLJ44299 2

External Ids for CIBAR2 Gene

Previous HGNC Symbols for CIBAR2 Gene

  • FAM92B

Summaries for CIBAR2 Gene

GeneCards Summary for CIBAR2 Gene

CIBAR2 (CBY1 Interacting BAR Domain Containing 2) is a Protein Coding gene. Diseases associated with CIBAR2 include Inflammatory Bowel Disease 5. An important paralog of this gene is CIBAR1.

UniProtKB/Swiss-Prot Summary for CIBAR2 Gene

  • May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616).

Additional gene information for CIBAR2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CIBAR2 Gene

Genomics for CIBAR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CIBAR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CIBAR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CIBAR2

Genomic Locations for CIBAR2 Gene

Genomic Locations for CIBAR2 Gene
chr16:85,098,358-85,112,508
(GRCh38/hg38)
Size:
14,151 bases
Orientation:
Minus strand
chr16:85,131,965-85,146,114
(GRCh37/hg19)
Size:
14,150 bases
Orientation:
Minus strand

Genomic View for CIBAR2 Gene

Genes around CIBAR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIBAR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIBAR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIBAR2 Gene

Proteins for CIBAR2 Gene

  • Protein details for CIBAR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZTR7-CBAR2_HUMAN
    Recommended name:
    CBY1-interacting BAR domain-containing protein 2
    Protein Accession:
    Q6ZTR7
    Secondary Accessions:
    • A0A0D9SG36

    Protein attributes for CIBAR2 Gene

    Size:
    304 amino acids
    Molecular mass:
    34755 Da
    Quaternary structure:
    • Homodimer (via BAR-like domain) (PubMed:27528616). Heterodimer (via BAR-like domain) with FAM92A (PubMed:27528616). Interacts with CBY1 (PubMed:27528616).

neXtProt entry for CIBAR2 Gene

Post-translational modifications for CIBAR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CIBAR2 Gene

No data available for DME Specific Peptides for CIBAR2 Gene

Domains & Families for CIBAR2 Gene

Gene Families for CIBAR2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CIBAR2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CIBAR2 Gene

GenScript: Design optimal peptide antigens:
  • Family with sequence similarity 92, member B, isoform CRA_a (D3DUM3_HUMAN)
  • Protein FAM92B (FA92B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZTR7

UniProtKB/Swiss-Prot:

CBAR2_HUMAN :
  • The BAR-like domain displays limited similarity to other BAR domains.
  • Belongs to the CIBAR family.
Domain:
  • The BAR-like domain displays limited similarity to other BAR domains.
Family:
  • Belongs to the CIBAR family.
genes like me logo Genes that share domains with CIBAR2: view

Function for CIBAR2 Gene

Molecular function for CIBAR2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616).

Phenotypes From GWAS Catalog for CIBAR2 Gene

Gene Ontology (GO) - Molecular Function for CIBAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27528616
genes like me logo Genes that share ontologies with CIBAR2: view
genes like me logo Genes that share phenotypes with CIBAR2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CIBAR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CIBAR2 Gene

Localization for CIBAR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIBAR2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=Extensive colocalization with CBY1 at mother centrioles. {ECO:0000250 UniProtKB:Q3V2J0}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CIBAR2 gene
Compartment Confidence
cytoskeleton 3
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for CIBAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IEA --
GO:0005856 cytoskeleton IEA --
GO:0036064 ciliary basal body IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with CIBAR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CIBAR2 Gene

Pathways & Interactions for CIBAR2 Gene

PathCards logo

SuperPathways for CIBAR2 Gene

No Data Available

Interacting Proteins for CIBAR2 Gene

STRING Interaction Network Preview (showing top 4 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000443411 for CIBAR2 Gene via STRING

Gene Ontology (GO) - Biological Process for CIBAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with CIBAR2: view

No data available for Pathways by source and SIGNOR curated interactions for CIBAR2 Gene

Drugs & Compounds for CIBAR2 Gene

No Compound Related Data Available

Transcripts for CIBAR2 Gene

mRNA/cDNA for CIBAR2 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CIBAR2

Alternative Splicing Database (ASD) splice patterns (SP) for CIBAR2 Gene

No ASD Table

Relevant External Links for CIBAR2 Gene

GeneLoc Exon Structure for
CIBAR2

Expression for CIBAR2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CIBAR2

SOURCE GeneReport for Unigene cluster for CIBAR2 Gene:

Hs.125713

mRNA Expression by UniProt/SwissProt for CIBAR2 Gene:

Q6ZTR7-CBAR2_HUMAN
Tissue specificity: Restricted to certain tissues, most prominently expressed in multicilaited tissues.

Evidence on tissue expression from TISSUES for CIBAR2 Gene

  • Lung(4.2)
  • Heart(4.1)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CIBAR2 Gene

Orthologs for CIBAR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CIBAR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM92B 30 31
  • 98.9 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fam92b 30 31
  • 83.07 (n)
OneToOne
Cibar2 17
Cow
(Bos Taurus)
Mammalia FAM92B 30 31
  • 81.76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fam92b 30
  • 80.82 (n)
Dog
(Canis familiaris)
Mammalia FAM92B 30 31
  • 79.98 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FAM92B 31
  • 73 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FAM92B 31
  • 58 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam92b 30
  • 64.96 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12567 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG6405 31
  • 17 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11121 31
  • 29 (a)
OneToMany
Species where no ortholog for CIBAR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CIBAR2 Gene

ENSEMBL:
Gene Tree for CIBAR2 (if available)
TreeFam:
Gene Tree for CIBAR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CIBAR2: view image

Paralogs for CIBAR2 Gene

Paralogs for CIBAR2 Gene

genes like me logo Genes that share paralogs with CIBAR2: view

Variants for CIBAR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CIBAR2 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs9934891 - p.Glu22Lys

Additional dbSNP identifiers (rs#s) for CIBAR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CIBAR2 Gene

Variant ID Type Subtype PubMed ID
dgv3059n100 CNV gain 25217958
nsv1066002 CNV loss 25217958
nsv1066260 CNV gain 25217958
nsv483044 CNV gain 15286789
nsv573474 CNV loss 21841781

Variation tolerance for CIBAR2 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CIBAR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CIBAR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIBAR2 Gene

Disorders for CIBAR2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CIBAR2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
inflammatory bowel disease 5
  • ibd5
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CIBAR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CIBAR2 Gene

Publications for CIBAR2 Gene

  1. BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis. (PMID: 27528616) Li FQ … Takemaru KI (Molecular and cellular biology 2016) 2 3 4
  2. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. (PMID: 28700943) Martin TD … Elledge SJ (Cell reports 2017) 3
  3. NELL1, NCF4, and FAM92B genes are not major susceptibility genes for Crohn's disease in Canadian children and young adults. (PMID: 21472827) Amre DK … Levy E (Inflammatory bowel diseases 2012) 3
  4. rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population. (PMID: 19262523) Glas J … Brand S (The American journal of gastroenterology 2009) 3
  5. Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort. (PMID: 18580884) Roberts RL … Merriman TR (Genes and immunity 2008) 3

Products for CIBAR2 Gene

Sources for CIBAR2 Gene