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Aliases for CIB3 Gene

Aliases for CIB3 Gene

  • Calcium And Integrin Binding Family Member 3 2 3 5
  • KIP3 3 4
  • DNA-Dependent Protein Kinase Catalytic Subunit-Interacting Protein 3 3
  • Calcium And Integrin-Binding Family Member 3 3
  • Kinase-Interacting Protein 3 4
  • KIP 3 4

External Ids for CIB3 Gene

Previous GeneCards Identifiers for CIB3 Gene

  • GC00U914336
  • GC19M016134
  • GC19M016272
  • GC19M015842

Summaries for CIB3 Gene

Entrez Gene Summary for CIB3 Gene

  • This gene product shares a high degree of sequence similarity with DNA-dependent protein kinase catalytic subunit-interacting protein 2 in human and mouse, and like them may bind the catalytic subunit of DNA-dependent protein kinases. The exact function of this gene is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for CIB3 Gene

CIB3 (Calcium And Integrin Binding Family Member 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CIB2.

Additional gene information for CIB3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIB3 Gene

Genomics for CIB3 Gene

GeneHancer (GH) Regulatory Elements for CIB3 Gene

Promoters and enhancers for CIB3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J016172 Promoter/Enhancer 1.3 EPDnew ENCODE 650.7 +0.3 333 1.6 CLOCK NFIB ZSCAN4 NEUROD1 BMI1 ZBTB7B ZNF207 RCOR1 EGR2 GATAD2B GC19M016168 CIB3 AP1M1 ENSG00000269243
GH19J016091 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 12.1 +78.3 78267 7.6 FOXA2 ARID4B DMAP1 ZNF48 ETS1 POLR2B ATF7 RXRA SP5 KAT8 HSH2D CIB3 FAM32A EPS15L1 RAB8A ENSG00000267373 ENSG00000279198 TPM4
GH19J016148 Enhancer 1 Ensembl ENCODE dbSUPER 13.8 +23.9 23858 2.9 CEBPB ZMYM3 OSR2 ATF4 POLR2A ZFP36 ETV6 MLLT1 RUNX3 SPI1 CIB3 FAM32A AP1M1 ENSG00000269243 HSH2D
GH19J016040 Enhancer 1 Ensembl ENCODE 11.8 +132.3 132294 1.5 ELF3 RB1 ARID4B IRF4 ZNF48 RAD21 YY1 ZNF335 ZNF121 ZNF143 GC19P020373 GC19P020374 GC19P020517 PIR40891 PIR57771 PIR58392 PIR42646 PIR34872 PIR43139 PIR51467
GH19J016101 Enhancer 0.2 dbSUPER 12.1 +71.8 71756 0.9 TPM4 CIB3 FAM32A AP1M1 ENSG00000267373 ENSG00000279198
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CIB3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CIB3 gene promoter:
  • POU3F2
  • LUN-1
  • AML1a
  • Pbx1a
  • C/EBPalpha
  • GATA-2
  • ER-alpha
  • RFX1
  • POU6F1 (c2)
  • Pax-3

Genomic Locations for CIB3 Gene

Genomic Locations for CIB3 Gene
12,158 bases
Minus strand
12,158 bases
Minus strand

Genomic View for CIB3 Gene

Genes around CIB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIB3 Gene

Proteins for CIB3 Gene

  • Protein details for CIB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium and integrin-binding family member 3
    Protein Accession:
    Secondary Accessions:
    • E7EUX1
    • Q2M1W0
    • Q6ISP1

    Protein attributes for CIB3 Gene

    187 amino acids
    Molecular mass:
    21802 Da
    Quaternary structure:
    • Interacts with ITGA2B (via C-terminus cytoplasmic tail region); the interaction is stabilized/increased in a calcium and magnesium-dependent manner.
    • The binding of either calcium or magnesium significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form).

    Alternative splice isoforms for CIB3 Gene


neXtProt entry for CIB3 Gene

Post-translational modifications for CIB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CIB3 Gene

No data available for DME Specific Peptides for CIB3 Gene

Domains & Families for CIB3 Gene

Gene Families for CIB3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CIB3 Gene

Suggested Antigen Peptide Sequences for CIB3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CIB3: view

No data available for UniProtKB/Swiss-Prot for CIB3 Gene

Function for CIB3 Gene

Phenotypes From GWAS Catalog for CIB3 Gene

Gene Ontology (GO) - Molecular Function for CIB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 22779914
GO:0005509 calcium ion binding IDA 22779914
GO:0005515 protein binding IPI 22779914
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CIB3: view
genes like me logo Genes that share phenotypes with CIB3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CIB3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CIB3 Gene

Localization for CIB3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CIB3 gene
Compartment Confidence
cytoskeleton 2
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
peroxisome 1
nucleus 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CIB3 Gene

Pathways & Interactions for CIB3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CIB3 Gene


No data available for Pathways by source and SIGNOR curated interactions for CIB3 Gene

Drugs & Compounds for CIB3 Gene

No Compound Related Data Available

Transcripts for CIB3 Gene

mRNA/cDNA for CIB3 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CIB3 Gene

Calcium and integrin binding family member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CIB3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIB3 Gene

No ASD Table

Relevant External Links for CIB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CIB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CIB3 Gene

mRNA differential expression in normal tissues according to GTEx for CIB3 Gene

This gene is overexpressed in Testis (x27.7) and Whole Blood (x8.6).

NURSA nuclear receptor signaling pathways regulating expression of CIB3 Gene:


SOURCE GeneReport for Unigene cluster for CIB3 Gene:

genes like me logo Genes that share expression patterns with CIB3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CIB3 Gene

Orthologs for CIB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CIB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CIB3 34 33
  • 98.75 (n)
(Bos Taurus)
Mammalia CIB3 34 33
  • 91.09 (n)
(Canis familiaris)
Mammalia CIB3 34 33
  • 91.09 (n)
(Mus musculus)
Mammalia Cib3 16 34 33
  • 85 (n)
(Rattus norvegicus)
Mammalia Cib3 33
  • 84.85 (n)
(Ornithorhynchus anatinus)
Mammalia CIB3 34
  • 84 (a)
(Monodelphis domestica)
Mammalia CIB3 34
  • 72 (a)
(Gallus gallus)
Aves CIB3 34 33
  • 75.58 (n)
(Anolis carolinensis)
Reptilia CIB3 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cib3 33
  • 73.15 (n)
(Danio rerio)
Actinopterygii CABZ01118627.1 34
  • 82 (a)
LOC100535603 33
  • 77.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9236 34
  • 55 (a)
(Caenorhabditis elegans)
Secernentea calm-1 34
  • 46 (a)
Species where no ortholog for CIB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CIB3 Gene

Gene Tree for CIB3 (if available)
Gene Tree for CIB3 (if available)
Evolutionary constrained regions (ECRs) for CIB3: view image

Paralogs for CIB3 Gene

Paralogs for CIB3 Gene

(7) SIMAP similar genes for CIB3 Gene using alignment to 6 proteins:

  • M0QZ29_HUMAN
  • Q6NT26_HUMAN
  • Q6NT60_HUMAN
genes like me logo Genes that share paralogs with CIB3: view

Variants for CIB3 Gene

Sequence variations from dbSNP and Humsavar for CIB3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000117430 -- 16,172,298(-) G/A intron_variant
rs1000593074 -- 16,164,405(-) G/C intron_variant
rs1000840016 -- 16,165,512(-) C/T intron_variant
rs1000951871 -- 16,171,710(-) C/A intron_variant
rs1001394981 -- 16,170,704(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CIB3 Gene

Variant ID Type Subtype PubMed ID
nsv833767 CNV loss 17160897
esv3643791 CNV loss 21293372

Variation tolerance for CIB3 Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CIB3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIB3 Gene

Disorders for CIB3 Gene

Additional Disease Information for CIB3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CIB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIB3 Gene

Publications for CIB3 Gene

  1. Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences. (PMID: 22779914) Huang H … Vogel HJ (Biochemistry and cell biology = Biochimie et biologie cellulaire 2012) 3 4 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PMID: 21085059) Israni A … DeKAF Investigators (Transplantation 2010) 44 58
  4. Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins. (PMID: 15574431) Gentry HR … Parise LV (The Journal of biological chemistry 2005) 3 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for CIB3 Gene

Sources for CIB3 Gene

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