Aliases for CIART Gene
External Ids for CIART Gene
Previous HGNC Symbols for CIART Gene
Previous GeneCards Identifiers for CIART Gene
GeneCards Summary for CIART Gene
CIART (Circadian Associated Repressor Of Transcription) is a Protein Coding gene. Diseases associated with CIART include Carotid Artery Thrombosis and Polycystic Echinococcosis. Among its related pathways are Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include core promoter sequence-specific DNA binding and E-box binding.
UniProtKB/Swiss-Prot Summary for CIART Gene
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).