Aliases for CIAPIN1 Gene
External Ids for CIAPIN1 Gene
Previous GeneCards Identifiers for CIAPIN1 Gene
CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CIAPIN1 Gene
CIAPIN1 (Cytokine Induced Apoptosis Inhibitor 1) is a Protein Coding gene. Diseases associated with CIAPIN1 include Aceruloplasminemia. Among its related pathways are Cytosolic iron-sulfur cluster assembly and Metabolism. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and iron-sulfur cluster binding.
UniProtKB/Swiss-Prot Summary for CIAPIN1 Gene
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity).