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Aliases for CIAPIN1 Gene

Aliases for CIAPIN1 Gene

  • Cytokine Induced Apoptosis Inhibitor 1 2 3 5
  • Fe-S Cluster Assembly Protein DRE2 Homolog 3 4
  • Cytokine-Induced Apoptosis Inhibitor 1 4
  • Predicted Protein Of HQ0915 3
  • Anamorsin 3
  • PRO0915 3
  • DRE2 3

External Ids for CIAPIN1 Gene

Previous GeneCards Identifiers for CIAPIN1 Gene

  • GC16M056019
  • GC16M043329

Summaries for CIAPIN1 Gene

Entrez Gene Summary for CIAPIN1 Gene

  • CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CIAPIN1 Gene

CIAPIN1 (Cytokine Induced Apoptosis Inhibitor 1) is a Protein Coding gene. Among its related pathways are Metabolism and Cytosolic iron-sulfur cluster assembly. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and iron-sulfur cluster binding.

UniProtKB/Swiss-Prot for CIAPIN1 Gene

  • Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein NDOR1.

Gene Wiki entry for CIAPIN1 Gene

Additional gene information for CIAPIN1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIAPIN1 Gene

Genomics for CIAPIN1 Gene

GeneHancer (GH) Regulatory Elements for CIAPIN1 Gene

Promoters and enhancers for CIAPIN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I057446 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 568.2 +0.2 188 2.4 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B CBX5 CIAPIN1 COQ9 ADGRG5 GC16P057442
GH16I057482 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 21.1 -37.3 -37293 5.3 HDGF ATF1 FOXA2 MLX ARID4B SIN3A ZNF48 SLC30A9 GLIS2 ZNF213 DOK4 CIAPIN1 COQ9 LOC105371286 POLR2C CX3CL1 CCL22 USB1 PIR51542
GH16I057462 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 16.6 -15.4 -15365 1.8 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF766 ENSG00000260345 POLR2C RSPRY1 CIAPIN1 CSNK2A2 NLRC5 DOK4 CCDC102A PIR63065
GH16I057371 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.3 +74.5 74468 3.4 FOXA2 SMAD1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 RXRA SP5 CX3CL1 CIAPIN1 GC16M057308
GH16I057477 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 13.6 -32.2 -32245 4.2 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 GLIS2 DOK4 COQ9 CIAPIN1 CCDC102A PIR51542
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CIAPIN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CIAPIN1 gene promoter:

Genomic Locations for CIAPIN1 Gene

Genomic Locations for CIAPIN1 Gene
chr16:57,428,169-57,447,528
(GRCh38/hg38)
Size:
19,360 bases
Orientation:
Minus strand
chr16:57,462,081-57,481,440
(GRCh37/hg19)

Genomic View for CIAPIN1 Gene

Genes around CIAPIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIAPIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIAPIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIAPIN1 Gene

Proteins for CIAPIN1 Gene

  • Protein details for CIAPIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6FI81-CPIN1_HUMAN
    Recommended name:
    Anamorsin
    Protein Accession:
    Q6FI81
    Secondary Accessions:
    • A8K8B6
    • O75206
    • O75207
    • Q9H0W1
    • Q9P1L7

    Protein attributes for CIAPIN1 Gene

    Size:
    312 amino acids
    Molecular mass:
    33582 Da
    Cofactor:
    Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
    Quaternary structure:
    • Monomer. Interacts with NDOR1; its oxidized form can be reduced by NDOR1. Interacts with CHCHD4 and may be a substrate for CHCHD4 chaperone activity.
    Miscellaneous:
    • Ana-mors-in means anti-death molecule in Latin.
    SequenceCaution:
    • Sequence=AAC24312.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CIAPIN1 Gene

    Alternative splice isoforms for CIAPIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CIAPIN1 Gene

Post-translational modifications for CIAPIN1 Gene

  • Ubiquitination at Lys31, posLast=4848, and posLast=9696
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CIAPIN1 Gene

Domains & Families for CIAPIN1 Gene

Protein Domains for CIAPIN1 Gene

Suggested Antigen Peptide Sequences for CIAPIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6FI81

UniProtKB/Swiss-Prot:

CPIN1_HUMAN :
  • The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine.
  • Belongs to the anamorsin family.
Domain:
  • The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine.
  • The C-terminal domain binds one 2Fe-2S iron-sulfur cluster but is otherwise mostly in an intrinsically disordered conformation.
  • The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.
Family:
  • Belongs to the anamorsin family.
genes like me logo Genes that share domains with CIAPIN1: view

Function for CIAPIN1 Gene

Molecular function for CIAPIN1 Gene

UniProtKB/Swiss-Prot Function:
Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein NDOR1.

Gene Ontology (GO) - Molecular Function for CIAPIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008168 methyltransferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding IEA --
GO:0051537 2 iron, 2 sulfur cluster binding IDA,IEA 27519415
genes like me logo Genes that share ontologies with CIAPIN1: view
genes like me logo Genes that share phenotypes with CIAPIN1: view

Animal Models for CIAPIN1 Gene

MGI Knock Outs for CIAPIN1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CIAPIN1

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CIAPIN1 Gene

Localization for CIAPIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIAPIN1 Gene

Cytoplasm. Nucleus. Mitochondrion. Mitochondrion intermembrane space. Note=Imported into mitochondria (in vitro).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CIAPIN1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
extracellular 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CIAPIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA 16957168
GO:0005737 cytoplasm ISS,IEA 14970183
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with CIAPIN1: view

Pathways & Interactions for CIAPIN1 Gene

genes like me logo Genes that share pathways with CIAPIN1: view

Pathways by source for CIAPIN1 Gene

1 GeneTex pathway for CIAPIN1 Gene
2 Reactome pathways for CIAPIN1 Gene

Gene Ontology (GO) - Biological Process for CIAPIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0008152 metabolic process IEA --
GO:0016226 iron-sulfur cluster assembly IBA,IEA --
GO:0030097 hemopoiesis IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with CIAPIN1: view

No data available for SIGNOR curated interactions for CIAPIN1 Gene

Drugs & Compounds for CIAPIN1 Gene

(5) Drugs for CIAPIN1 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
GDC-0152 Investigational Pharma IAP antagonist,potent amd samll-molecule 0
Birinapant (TL32711) Pharma Potent XIAP/cIAP1 antagonist 0
BV6 Pharma 0
SM-164 Pharma Anticancer agent 0
YM155 Pharma Survivin suppressant,apoptosis inhibitor, Survivin inhibitors 0

(5) ApexBio Compounds for CIAPIN1 Gene

Compound Action Cas Number
Birinapant (TL32711) Potent XIAP/cIAP1 antagonist 1260251-31-7
BV6 1001600-56-1
GDC-0152 IAP antagonist,potent amd samll-molecule 873652-48-3
SM-164 Anticancer agent 957135-43-2
YM155 Survivin suppressant,apoptosis inhibitor 781661-94-7
genes like me logo Genes that share compounds with CIAPIN1: view

Drug Products

Transcripts for CIAPIN1 Gene

Unigene Clusters for CIAPIN1 Gene

Cytokine induced apoptosis inhibitor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIAPIN1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: -
SP2:
SP3: -
SP4: -
SP5:

Relevant External Links for CIAPIN1 Gene

GeneLoc Exon Structure for
CIAPIN1
ECgene alternative splicing isoforms for
CIAPIN1

Expression for CIAPIN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CIAPIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CIAPIN1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.6), Cervix (6.6), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CIAPIN1 Gene



Protein tissue co-expression partners for CIAPIN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CIAPIN1 Gene:

CIAPIN1

SOURCE GeneReport for Unigene cluster for CIAPIN1 Gene:

Hs.4900

mRNA Expression by UniProt/SwissProt for CIAPIN1 Gene:

Q6FI81-CPIN1_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in heart, liver and pancreas.

Evidence on tissue expression from TISSUES for CIAPIN1 Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Skin(4.2)
  • Lung(2)
genes like me logo Genes that share expression patterns with CIAPIN1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CIAPIN1 Gene

Orthologs for CIAPIN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CIAPIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CIAPIN1 33 34
  • 99.04 (n)
cow
(Bos Taurus)
Mammalia CIAPIN1 33 34
  • 89.35 (n)
dog
(Canis familiaris)
Mammalia CIAPIN1 33 34
  • 88.03 (n)
rat
(Rattus norvegicus)
Mammalia Ciapin1 33
  • 83.93 (n)
mouse
(Mus musculus)
Mammalia Ciapin1 33 16 34
  • 82.96 (n)
oppossum
(Monodelphis domestica)
Mammalia CIAPIN1 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
OneToMany
-- 34
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves CIAPIN1 33 34
  • 72.34 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 82 (a)
OneToMany
-- 34
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ciapin1 33
  • 60.73 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398841 33
zebrafish
(Danio rerio)
Actinopterygii ciapin1 33 34
  • 60.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta DRE2_ANOGA 33
  • 55.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(2)35Bg 33 34
  • 55.22 (n)
worm
(Caenorhabditis elegans)
Secernentea T20B12.7 34
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DRE2 34
  • 24 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G18400 33
  • 49.92 (n)
rice
(Oryza sativa)
Liliopsida Os04g0674400 33
  • 51.01 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9538 34
  • 45 (a)
OneToOne
Species where no ortholog for CIAPIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CIAPIN1 Gene

ENSEMBL:
Gene Tree for CIAPIN1 (if available)
TreeFam:
Gene Tree for CIAPIN1 (if available)

Paralogs for CIAPIN1 Gene

Pseudogenes.org Pseudogenes for CIAPIN1 Gene

genes like me logo Genes that share paralogs with CIAPIN1: view

No data available for Paralogs for CIAPIN1 Gene

Variants for CIAPIN1 Gene

Sequence variations from dbSNP and Humsavar for CIAPIN1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs547268811 uncertain-significance, Coenzyme Q10 deficiency, primary 57,447,481(-) C/G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs749532852 uncertain-significance, Coenzyme Q10 deficiency, primary 57,447,583(-) GGGGG/GGGG upstream_transcript_variant
rs975754474 uncertain-significance, Coenzyme Q10 deficiency, primary 57,447,469(-) C/A/G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs536567108 likely-benign, not specified 57,447,531(-) C/G/T upstream_transcript_variant
rs538303703 likely-benign, not specified 57,447,539(-) C/G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CIAPIN1 Gene

Variant ID Type Subtype PubMed ID
nsv833245 CNV loss 17160897
nsv978155 CNV duplication 23825009

Variation tolerance for CIAPIN1 Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.70; 57.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CIAPIN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CIAPIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIAPIN1 Gene

Disorders for CIAPIN1 Gene

Additional Disease Information for CIAPIN1

No disorders were found for CIAPIN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIAPIN1 Gene

Publications for CIAPIN1 Gene

  1. A Glutaredoxin·BolA Complex Serves as an Iron-Sulfur Cluster Chaperone for the Cytosolic Cluster Assembly Machinery. (PMID: 27519415) Frey AG … Philpott CC (The Journal of biological chemistry 2016) 2 3 4 58
  2. Molecular view of an electron transfer process essential for iron-sulfur protein biogenesis. (PMID: 23596212) Banci L … Winkelmann J (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4 58
  3. Anamorsin is a [2Fe-2S] cluster-containing substrate of the Mia40-dependent mitochondrial protein trapping machinery. (PMID: 21700214) Banci L … Winkelmann J (Chemistry & biology 2011) 3 4 58
  4. A cell-death-defying factor, anamorsin mediates cell growth through inactivation of PKC and p38MAPK. (PMID: 21219862) Saito Y … Kanakura Y (Biochemical and biophysical research communications 2011) 2 3 58
  5. Dre2, a conserved eukaryotic Fe/S cluster protein, functions in cytosolic Fe/S protein biogenesis. (PMID: 18625724) Zhang Y … Dancis A (Molecular and cellular biology 2008) 3 22 58

Products for CIAPIN1 Gene

Sources for CIAPIN1 Gene

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