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Aliases for CIAO2B Gene

Aliases for CIAO2B Gene

  • Cytosolic Iron-Sulfur Assembly Component 2B 2 3
  • Family With Sequence Similarity 96 Member B 2 3 5
  • MSS19-Interacting Protein Of 18 KDa 3 4
  • FAM96B 3 5
  • MIP18 3 4
  • Mitotic Spindle-Associated MMXD Complex Subunit MIP18 3
  • Protein FAM96B 4
  • CGI-128 3
  • CIA2B 3

External Ids for CIAO2B Gene

Previous HGNC Symbols for CIAO2B Gene

  • FAM96B

Summaries for CIAO2B Gene

GeneCards Summary for CIAO2B Gene

CIAO2B (Cytosolic Iron-Sulfur Assembly Component 2B) is a Protein Coding gene. Among its related pathways are Metabolism and Glucose / Energy Metabolism. An important paralog of this gene is CIAO2A.

UniProtKB/Swiss-Prot for CIAO2B Gene

  • Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD.

Additional gene information for CIAO2B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CIAO2B Gene

Genomics for CIAO2B Gene

GeneHancer (GH) Regulatory Elements for CIAO2B Gene

Promoters and enhancers for CIAO2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J066932 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.9 -878 5 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B E2F8 CES2 CIAO2B CES3 NAE1 ENSG00000265408
GH16J066902 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 12.1 +29.9 29882 4.1 PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B DMAP1 ZNF2 ZNF48 ATF7 CES2 KIAA0895L E2F4 NAE1 RRAD CIAO2B EDC4 CENPT CTCF EXOC3L1
GH16J066879 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.3 +53.7 53651 2 PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 PDP2 EDC4 CTCF CES2 CENPT E2F4 ENSG00000260465 CDH16 RRAD NAE1
GH16J066871 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE 10.9 +60.6 60583 5.1 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 ZNF213 NAE1 E2F4 CTCF CES2 CA7 EDC4 CENPT PLEKHG4 ZDHHC1 ACD
GH16J066960 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 11.5 -26.7 -26697 1 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZNF48 ZNF143 ATF7 DEK CES3 FBXL8 TRADD HSF4 CES2 RRAD CDH16 CIAO2B B3GNT9 CBFB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CIAO2B on UCSC Golden Path with GeneCards custom track

Genomic Locations for CIAO2B Gene

Genomic Locations for CIAO2B Gene
chr16:66,932,055-66,934,423
(GRCh38/hg38)
Size:
2,369 bases
Orientation:
Minus strand
chr16:66,965,958-66,968,326
(GRCh37/hg19)

Genomic View for CIAO2B Gene

Genes around CIAO2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CIAO2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CIAO2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CIAO2B Gene

Proteins for CIAO2B Gene

  • Protein details for CIAO2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3D0-MIP18_HUMAN
    Recommended name:
    Mitotic spindle-associated MMXD complex subunit MIP18
    Protein Accession:
    Q9Y3D0

    Protein attributes for CIAO2B Gene

    Size:
    163 amino acids
    Molecular mass:
    17663 Da
    Quaternary structure:
    • Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with ERCC2 and MMS19; the interaction is direct.

neXtProt entry for CIAO2B Gene

Post-translational modifications for CIAO2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CIAO2B Gene

No data available for DME Specific Peptides for CIAO2B Gene

Domains & Families for CIAO2B Gene

Gene Families for CIAO2B Gene

Protein Domains for CIAO2B Gene

Suggested Antigen Peptide Sequences for CIAO2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3D0

UniProtKB/Swiss-Prot:

MIP18_HUMAN :
  • Belongs to the MIP18 family.
Family:
  • Belongs to the MIP18 family.
genes like me logo Genes that share domains with CIAO2B: view

Function for CIAO2B Gene

Molecular function for CIAO2B Gene

UniProtKB/Swiss-Prot Function:
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD.

Phenotypes From GWAS Catalog for CIAO2B Gene

Gene Ontology (GO) - Molecular Function for CIAO2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CIAO2B: view
genes like me logo Genes that share phenotypes with CIAO2B: view

Animal Model Products

CRISPR Products

miRNA for CIAO2B Gene

miRTarBase miRNAs that target CIAO2B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CIAO2B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CIAO2B Gene

Localization for CIAO2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CIAO2B Gene

Nucleus. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CIAO2B gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CIAO2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 20797633
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 20797633
GO:0005819 spindle IDA,IEA 20797633
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CIAO2B: view

Pathways & Interactions for CIAO2B Gene

genes like me logo Genes that share pathways with CIAO2B: view

Pathways by source for CIAO2B Gene

2 Reactome pathways for CIAO2B Gene
1 Cell Signaling Technology pathway for CIAO2B Gene

Gene Ontology (GO) - Biological Process for CIAO2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IMP 20797633
GO:0016226 iron-sulfur cluster assembly IBA --
genes like me logo Genes that share ontologies with CIAO2B: view

No data available for SIGNOR curated interactions for CIAO2B Gene

Drugs & Compounds for CIAO2B Gene

No Compound Related Data Available

Transcripts for CIAO2B Gene

mRNA/cDNA for CIAO2B Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CIAO2B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CIAO2B Gene

No ASD Table

Relevant External Links for CIAO2B Gene

GeneLoc Exon Structure for
CIAO2B
ECgene alternative splicing isoforms for
CIAO2B

Expression for CIAO2B Gene

NURSA nuclear receptor signaling pathways regulating expression of CIAO2B Gene:

CIAO2B

Evidence on tissue expression from TISSUES for CIAO2B Gene

  • Liver(4.3)
  • Blood(4.2)
  • Eye(4.2)
  • Nervous system(2.8)
  • Pancreas(2.5)
  • Muscle(2.1)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CIAO2B Gene

Orthologs for CIAO2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CIAO2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM96B 34 33
  • 98.53 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM96B 34 33
  • 90.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM96B 34 33
  • 89.76 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam96b 33
  • 87.15 (n)
mouse
(Mus musculus)
Mammalia Fam96b 16 34 33
  • 86.49 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM96B 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM96B 34 33
  • 77.41 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM96B 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam96b 33
  • 73.9 (n)
Str.468 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.10194 33
zebrafish
(Danio rerio)
Actinopterygii fam96b 34 33
  • 72.37 (n)
OneToOne
wufc08f04 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10450 33
fruit fly
(Drosophila melanogaster)
Insecta CG7949 34 33
  • 65.35 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005422 33
  • 64.67 (n)
worm
(Caenorhabditis elegans)
Secernentea F45G2.10 34 33
  • 58.56 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR343W 33
  • 55.32 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F24332g 33
  • 52.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CIA2 33
  • 52.07 (n)
-- 34
  • 33 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G68310 33
  • 58.22 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2327 33
rice
(Oryza sativa)
Liliopsida Os04g0595200 33
  • 58.39 (n)
Os.45029 33
barley
(Hordeum vulgare)
Liliopsida Hv.9354 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC144.16 33
  • 56.21 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02573 33
  • 52.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.2545 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2545 33
Species where no ortholog for CIAO2B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CIAO2B Gene

ENSEMBL:
Gene Tree for CIAO2B (if available)
TreeFam:
Gene Tree for CIAO2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CIAO2B: view image

Paralogs for CIAO2B Gene

Paralogs for CIAO2B Gene

genes like me logo Genes that share paralogs with CIAO2B: view

Variants for CIAO2B Gene

Sequence variations from dbSNP and Humsavar for CIAO2B Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000406021 -- 66,935,882(-) TCCTAGAA/TCCTAGAATCCTAGAA upstream_transcript_variant
rs1000967376 -- 66,933,369(-) A/C intron_variant
rs1002764377 -- 66,932,782(-) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1002905238 -- 66,934,168(-) T/C intron_variant, non_coding_transcript_variant, splice_acceptor_variant
rs1003225189 -- 66,932,478(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CIAO2B Gene

Variant ID Type Subtype PubMed ID
nsv572904 CNV loss 21841781
nsv827706 CNV loss 20364138

Variation tolerance for CIAO2B Gene

Residual Variation Intolerance Score: 43.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CIAO2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CIAO2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CIAO2B Gene

Disorders for CIAO2B Gene

Additional Disease Information for CIAO2B

No disorders were found for CIAO2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CIAO2B Gene

Publications for CIAO2B Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  3. Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. (PMID: 23891004) Stehling O … Lill R (Cell metabolism 2013) 2 3 58
  4. MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. (PMID: 22678361) Gari K … Boulton SJ (Science (New York, N.Y.) 2012) 3 4 58
  5. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PMID: 22678362) Stehling O … Lill R (Science (New York, N.Y.) 2012) 3 4 58

Products for CIAO2B Gene

Sources for CIAO2B Gene

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