Aliases for CIAO1 Gene
External Ids for CIAO1 Gene
Previous HGNC Symbols for CIAO1 Gene
Previous GeneCards Identifiers for CIAO1 Gene
GeneCards Summary for CIAO1 Gene
CIAO1 (Cytosolic Iron-Sulfur Assembly Component 1) is a Protein Coding gene. Diseases associated with CIAO1 include Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 6 and Xeroderma Pigmentosum, Variant Type. Among its related pathways are Glucose / Energy Metabolism and Metabolism.
UniProtKB/Swiss-Prot Summary for CIAO1 Gene
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:17937914, PubMed:23891004). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004). Seems to specifically modulate the transactivation activity of WT1 (PubMed:9556563). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633).