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Aliases for CHST13 Gene

Aliases for CHST13 Gene

  • Carbohydrate Sulfotransferase 13 2 3 5
  • Chondroitin 4-Sulfotransferase 3 2 3 4
  • Carbohydrate (Chondroitin 4) Sulfotransferase 13 2 3
  • Chondroitin 4-O-Sulfotransferase 3 3 4
  • C4ST-3 3 4
  • C4ST3 3 4
  • EC 2.8.2.5 4

External Ids for CHST13 Gene

Previous GeneCards Identifiers for CHST13 Gene

  • GC03P127525
  • GC03P127564
  • GC03P127725
  • GC03P126243
  • GC03P123622

Summaries for CHST13 Gene

Entrez Gene Summary for CHST13 Gene

  • The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1,4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. [provided by RefSeq, Aug 2011]

GeneCards Summary for CHST13 Gene

CHST13 (Carbohydrate Sulfotransferase 13) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and chondroitin 4-sulfotransferase activity. An important paralog of this gene is CHST11.

UniProtKB/Swiss-Prot for CHST13 Gene

  • Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan.

Additional gene information for CHST13 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST13 Gene

Genomics for CHST13 Gene

GeneHancer (GH) Regulatory Elements for CHST13 Gene

Promoters and enhancers for CHST13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I126522 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 609.6 +2.8 2833 8.6 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 SLC30A9 GLIS2 ATF7 CHST13 TXNRD3NB TXNRD3 NUP210P1 OR7E29P C3orf22 ZXDC UROC1
GH03I126523 Enhancer 1.1 Ensembl ENCODE dbSUPER 550.8 -1.9 -1872 0.8 CTCF SAP130 ARID4B ZMYM3 ZNF48 RAD21 YY1 TEAD3 ZNF335 ZNF664 CHST13 UROC1 C3orf22
GH03I126539 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 32.7 +17.1 17068 3.8 RFX5 RCOR1 FOS USF2 CEBPB SMARCB1 ZNF592 MAFF ZNF184 SMARCA4 CHST13 ZXDC C3orf22
GH03I126573 Enhancer 0.5 Ensembl 14.3 +49.4 49418 0.6 ZNF639 MEIS2 MAZ L3MBTL2 NRF1 PRDM10 MGA CHST13 GC03M126565 RNA5SP138 LOC105374090 GC03M126599 PIR51508 TXNRD3NB
GH03I126998 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 4.9 +477.3 477348 5.9 RING1 CTCF TEAD4 SIN3A EBF1 ELF1 DPF2 ETS1 SP1 POLR2A PLXNA1 CHST13 PIR55562 GC03P126709
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CHST13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CHST13 gene promoter:

Genomic Locations for CHST13 Gene

Genomic Locations for CHST13 Gene
chr3:126,524,283-126,543,291
(GRCh38/hg38)
Size:
19,009 bases
Orientation:
Plus strand
chr3:126,243,126-126,262,134
(GRCh37/hg19)

Genomic View for CHST13 Gene

Genes around CHST13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHST13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHST13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST13 Gene

Proteins for CHST13 Gene

  • Protein details for CHST13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NET6-CHSTD_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 13
    Protein Accession:
    Q8NET6
    Secondary Accessions:
    • Q3SYA3
    • Q3SYA5

    Protein attributes for CHST13 Gene

    Size:
    341 amino acids
    Molecular mass:
    38920 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CHST13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHST13 Gene

Post-translational modifications for CHST13 Gene

  • Glycosylation at posLast=331331
  • Modification sites at PhosphoSitePlus

Other Protein References for CHST13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHST13 Gene

Domains & Families for CHST13 Gene

Gene Families for CHST13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for CHST13 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NET6

UniProtKB/Swiss-Prot:

CHSTD_HUMAN :
  • Belongs to the sulfotransferase 2 family.
Family:
  • Belongs to the sulfotransferase 2 family.
genes like me logo Genes that share domains with CHST13: view

Function for CHST13 Gene

Molecular function for CHST13 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + chondroitin = adenosine 3,5-bisphosphate + chondroitin 4-sulfate.
UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan.

Enzyme Numbers (IUBMB) for CHST13 Gene

Gene Ontology (GO) - Molecular Function for CHST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity IDA 12080076
GO:0008146 sulfotransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0047756 chondroitin 4-sulfotransferase activity TAS,IEA --
genes like me logo Genes that share ontologies with CHST13: view
genes like me logo Genes that share phenotypes with CHST13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CHST13 Gene

Localization for CHST13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST13 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHST13 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CHST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS,IEA 12080076
genes like me logo Genes that share ontologies with CHST13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CHST13 Gene

Pathways & Interactions for CHST13 Gene

genes like me logo Genes that share pathways with CHST13: view

Gene Ontology (GO) - Biological Process for CHST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0016051 carbohydrate biosynthetic process IEA --
GO:0030206 chondroitin sulfate biosynthetic process IDA,TAS --
genes like me logo Genes that share ontologies with CHST13: view

No data available for SIGNOR curated interactions for CHST13 Gene

Drugs & Compounds for CHST13 Gene

(1) Drugs for CHST13 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chondroitin Nutra 48

(3) Additional Compounds for CHST13 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Chondroitin 4-sulfate
  • Chondroitin 4'-sulfate
  • Chondroitin 4'-sulphate
  • Chondroitin sulfate A
  • Chondroitin sulphate A
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with CHST13: view

Transcripts for CHST13 Gene

mRNA/cDNA for CHST13 Gene

Unigene Clusters for CHST13 Gene

Carbohydrate (chondroitin 4) sulfotransferase 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHST13 Gene

No ASD Table

Relevant External Links for CHST13 Gene

GeneLoc Exon Structure for
CHST13
ECgene alternative splicing isoforms for
CHST13

Expression for CHST13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHST13 Gene

mRNA differential expression in normal tissues according to GTEx for CHST13 Gene

This gene is overexpressed in Liver (x24.4), Testis (x10.2), and Whole Blood (x8.7).

Protein differential expression in normal tissues from HIPED for CHST13 Gene

This gene is overexpressed in Platelet (46.8), Fetal Liver (12.4), and Testis (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHST13 Gene



Protein tissue co-expression partners for CHST13 Gene

NURSA nuclear receptor signaling pathways regulating expression of CHST13 Gene:

CHST13

SOURCE GeneReport for Unigene cluster for CHST13 Gene:

Hs.292375

mRNA Expression by UniProt/SwissProt for CHST13 Gene:

Q8NET6-CHSTD_HUMAN
Tissue specificity: Highly expressed in adult liver. Expressed at lower level in kidney, lymph nodes and fetal kidney.

Evidence on tissue expression from TISSUES for CHST13 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with CHST13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHST13 Gene

Orthologs for CHST13 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHST13 33 34
  • 96.96 (n)
dog
(Canis familiaris)
Mammalia CHST13 33
  • 87.77 (n)
cow
(Bos Taurus)
Mammalia CHST13 33 34
  • 86.92 (n)
rat
(Rattus norvegicus)
Mammalia Chst13 33
  • 80.37 (n)
mouse
(Mus musculus)
Mammalia Chst13 33 16 34
  • 80.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CHST13 34
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHST13 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHST13 34
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHST13 34
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CHST13 34
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31743 34
  • 36 (a)
OneToMany
Species where no ortholog for CHST13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHST13 Gene

ENSEMBL:
Gene Tree for CHST13 (if available)
TreeFam:
Gene Tree for CHST13 (if available)

Paralogs for CHST13 Gene

Paralogs for CHST13 Gene

(6) SIMAP similar genes for CHST13 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CHST13: view

Variants for CHST13 Gene

Sequence variations from dbSNP and Humsavar for CHST13 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000072177 -- 126,532,101(+) T/G intron_variant
rs1000190774 -- 126,539,559(+) GC/GCGC intron_variant
rs1000300113 -- 126,532,789(+) A/G intron_variant
rs1000486227 -- 126,532,537(+) A/G intron_variant
rs1000549130 -- 126,537,597(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CHST13 Gene

Variant ID Type Subtype PubMed ID
dgv2591n106 CNV tandem duplication 24896259
esv2435482 CNV insertion 19546169
esv2667811 CNV deletion 23128226
esv2725870 CNV deletion 23290073
esv2725871 CNV deletion 23290073
esv3426789 CNV duplication 20981092
nsv1137754 CNV deletion 24896259
nsv1145446 CNV deletion 24896259
nsv1149564 CNV deletion 26484159
nsv1151449 CNV insertion 26484159
nsv1153775 CNV deletion 26484159
nsv822240 CNV gain 20364138
nsv822241 CNV gain 20364138
nsv829717 CNV loss 17160897
nsv955338 CNV deletion 24416366

Variation tolerance for CHST13 Gene

Gene Damage Index Score: 10.89; 91.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHST13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHST13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST13 Gene

Disorders for CHST13 Gene

Additional Disease Information for CHST13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CHST13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHST13 Gene

Publications for CHST13 Gene

  1. Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases. (PMID: 12080076) Kang HG … Schachner M (The Journal of biological chemistry 2002) 2 3 4 22 58
  2. Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria. (PMID: 20580388) Valente B … Silveira H (Transactions of the Royal Society of Tropical Medicine and Hygiene 2010) 3 44 58
  3. CHST11/13 Regulate the Metastasis and Chemosensitivity of Human Hepatocellular Carcinoma Cells Via Mitogen-Activated Protein Kinase Pathway. (PMID: 26993826) Zhou H … Jia L (Digestive diseases and sciences 2016) 3 58
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58
  5. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PMID: 21085059) Israni A … DeKAF Investigators (Transplantation 2010) 44 58

Products for CHST13 Gene

Sources for CHST13 Gene

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