Aliases for CHST13 Gene
External Ids for CHST13 Gene
Previous GeneCards Identifiers for CHST13 Gene
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1,4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. [provided by RefSeq, Aug 2011]
GeneCards Summary for CHST13 Gene
CHST13 (Carbohydrate Sulfotransferase 13) is a Protein Coding gene. Diseases associated with CHST13 include Vitreoretinal Degeneration, Snowflake Type. Among its related pathways are Glycosaminoglycan metabolism and Chondroitin sulfate/dermatan sulfate metabolism. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and chondroitin 4-sulfotransferase activity. An important paralog of this gene is CHST11.
UniProtKB/Swiss-Prot Summary for CHST13 Gene
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan.