The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular ma... See more...

Aliases for CHST11 Gene

Aliases for CHST11 Gene

  • Carbohydrate Sulfotransferase 11 2 3 4 5
  • C4ST1 2 3 4
  • Carbohydrate (Chondroitin 4) Sulfotransferase 11 2 3
  • Chondroitin 4-O-Sulfotransferase 1 3 4
  • Chondroitin 4-Sulfotransferase 1 2 4
  • EC 2.8.2.5 4 51
  • HSA269537 2 3
  • C4ST-1 3 4
  • C4S-1 3 4
  • C4ST 2 3
  • IgH/CHST11 Fusion 3
  • CHST11 5
  • C4St-1 2
  • OCBMD 3

External Ids for CHST11 Gene

Previous GeneCards Identifiers for CHST11 Gene

  • GC12P104783
  • GC12P103353
  • GC12P103351
  • GC12P101909
  • GC12P104849

Summaries for CHST11 Gene

Entrez Gene Summary for CHST11 Gene

  • The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CHST11 Gene

CHST11 (Carbohydrate Sulfotransferase 11) is a Protein Coding gene. Diseases associated with CHST11 include Osteochondrodysplasia, Brachydactyly, And Overlapping Malformed Digits and Synpolydactyly. Among its related pathways are Glycosaminoglycan metabolism and Chondroitin sulfate/dermatan sulfate metabolism. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and chondroitin 4-sulfotransferase activity. An important paralog of this gene is CHST13.

UniProtKB/Swiss-Prot Summary for CHST11 Gene

  • Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.

Gene Wiki entry for CHST11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CHST11 Gene

Genomics for CHST11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CHST11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J104456 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 625.6 +3.6 3606 6.2 ZNF221 SP1 CTCF PRDM10 ZNF629 RFX1 IKZF1 ZNF692 POLR2A JUND CHST11 MN297186 lnc-CHST11-1 lnc-NFYB-2 SLC41A2
GH12J104454 Enhancer 0.7 ENCODE dbSUPER 606.3 -0.1 -97 0.2 SP1 SMARCC1 JUN FOSL1 ZFHX2 FOSL2 JUND FOS IKZF1 CHST11 lnc-CHST11-1 RF00017-1237 EID3
GH12J104666 Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 30.4 +215.2 215203 7.5 ARHGAP35 SP1 CREB1 CTCF PRDM10 ZNF629 LEF1 IKZF1 ZNF692 POLR2A CHST11 WASHC4 TDG RPL18AP3 EID3 HCFC2 TXNRD1 SLC41A2 LOC112268100 piR-49557
GH12J104602 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.4 +149.9 149882 4.8 CREB1 RFX1 LEF1 IKZF1 ZNF692 JUND FOXA1 PRDM1 ZSCAN4 PKNOX1 CHST11 TDG WASHC4 TXNRD1 EID3 piR-46381-022 MIR3922 SLC41A2
GH12J104719 Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 17.5 +266.0 265980 3.8 KDM1A ZIC2 ZSCAN4 TCF12 IKZF2 TRIM22 PKNOX1 EED ARID3A DPF2 CHST11 WASHC4 EID3 HSALNG0093667 piR-49557 SLC41A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CHST11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CHST11

Top Transcription factor binding sites by QIAGEN in the CHST11 gene promoter:
  • AML1a
  • C/EBPalpha
  • GATA-1
  • MyoD
  • NF-1
  • Nkx2-5
  • PPAR-gamma1
  • PPAR-gamma2
  • XBP-1
  • YY1

Genomic Locations for CHST11 Gene

Genomic Locations for CHST11 Gene
chr12:104,455,295-104,762,014
(GRCh38/hg38)
Size:
306,720 bases
Orientation:
Plus strand
chr12:104,849,073-105,155,792
(GRCh37/hg19)
Size:
306,720 bases
Orientation:
Plus strand

Genomic View for CHST11 Gene

Genes around CHST11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHST11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHST11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST11 Gene

Proteins for CHST11 Gene

  • Protein details for CHST11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPF2-CHSTB_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 11
    Protein Accession:
    Q9NPF2
    Secondary Accessions:
    • A8K4F8
    • Q9NXY6
    • Q9NY36

    Protein attributes for CHST11 Gene

    Size:
    352 amino acids
    Molecular mass:
    41555 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CHST11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHST11 Gene

Selected DME Specific Peptides for CHST11 Gene

Q9NPF2:
  • NLKTLNQYSIP
  • AKSTRTTD
  • CCRKGSR
  • YCYVPKVAC
  • PVMRRNPF
  • LFVREPFERLVSA
  • NEHWQTVYSLCHPCHIHYDLVGKYETLE

Post-translational modifications for CHST11 Gene

  • N-glycosylated; required for activity and stability.
  • Glycosylation at Asn205, Asn223, Asn321, and Asn342
  • Modification sites at PhosphoSitePlus

Other Protein References for CHST11 Gene

Protein Products

  • Signalway Proteins for CHST11
  • Abcam proteins for CHST11

Domains & Families for CHST11 Gene

Gene Families for CHST11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for CHST11 Gene

Suggested Antigen Peptide Sequences for CHST11 Gene

GenScript: Design optimal peptide antigens:
  • Chondroitin 4-sulfotransferase 1 (CHSTB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NPF2

UniProtKB/Swiss-Prot:

CHSTB_HUMAN :
  • Belongs to the sulfotransferase 2 family.
Family:
  • Belongs to the sulfotransferase 2 family.
genes like me logo Genes that share domains with CHST11: view

Function for CHST11 Gene

Molecular function for CHST11 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+); Xref=Rhea:RHEA:16101, Rhea:RHEA-COMP:9827, Rhea:RHEA-COMP:9829, ChEBI:CHEBI:15378, ChEBI:CHEBI:57652, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58422; EC=2.8.2.5; Evidence={ECO:0000269|PubMed:10781601, ECO:0000269|PubMed:11056388};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.5 uM for PAPS {ECO:0000269|PubMed:15628971}; KM=2.1 mM for chondroitin {ECO:0000269|PubMed:15628971};

Enzyme Numbers (IUBMB) for CHST11 Gene

Phenotypes From GWAS Catalog for CHST11 Gene

Gene Ontology (GO) - Molecular Function for CHST11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity IDA 11056388
GO:0008146 sulfotransferase activity IEA,IBA 21873635
GO:0016740 transferase activity IEA --
GO:0047756 chondroitin 4-sulfotransferase activity IEA,IDA 11056388
GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IEA --
genes like me logo Genes that share ontologies with CHST11: view
genes like me logo Genes that share phenotypes with CHST11: view

Human Phenotype Ontology for CHST11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CHST11 Gene

MGI Knock Outs for CHST11:
  • Chst11 Chst11<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHST11

No data available for Transcription Factor Targets and HOMER Transcription for CHST11 Gene

Localization for CHST11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST11 Gene

Golgi apparatus membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHST11 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 2
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CHST11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA,TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA,NAS 11056388
genes like me logo Genes that share ontologies with CHST11: view

Pathways & Interactions for CHST11 Gene

genes like me logo Genes that share pathways with CHST11: view

Gene Ontology (GO) - Biological Process for CHST11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0002063 chondrocyte development IEA --
GO:0005975 carbohydrate metabolic process IEA --
GO:0007585 respiratory gaseous exchange IEA --
GO:0009791 post-embryonic development IEA --
genes like me logo Genes that share ontologies with CHST11: view

No data available for SIGNOR curated interactions for CHST11 Gene

Drugs & Compounds for CHST11 Gene

(5) Drugs for CHST11 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
3'-phospho-5'-adenylyl sulfate Experimental Pharma 0
Adenosine 3',5'-diphosphate Experimental Pharma 0
Chondroitin Pharma 74

(5) Additional Compounds for CHST11 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dermatan
  • b-Heparin
  • beta-Heparin
  • Chondroitin sulfate b
  • Chondroitin sulfate type b
  • Chondroitin sulphate b
24967-94-0
genes like me logo Genes that share compounds with CHST11: view

Transcripts for CHST11 Gene

mRNA/cDNA for CHST11 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHST11

Alternative Splicing Database (ASD) splice patterns (SP) for CHST11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for CHST11 Gene

GeneLoc Exon Structure for
CHST11

Expression for CHST11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHST11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHST11 Gene

This gene is overexpressed in Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for CHST11 Gene

This gene is overexpressed in Pancreatic juice (19.5), Pancreas (17.4), Peripheral blood mononuclear cells (16.6), and Adrenal (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CHST11 Gene



Protein tissue co-expression partners for CHST11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CHST11

SOURCE GeneReport for Unigene cluster for CHST11 Gene:

Hs.17569

mRNA Expression by UniProt/SwissProt for CHST11 Gene:

Q9NPF2-CHSTB_HUMAN
Tissue specificity: Widely expressed. Highly expressed in spleen, thymus, bone marrow, peripheral blood leukocytes, lymph node, heart, brain, lung and placenta.

Evidence on tissue expression from TISSUES for CHST11 Gene

  • Nervous system(4.6)
  • Lung(4.4)
  • Skin(2.4)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with CHST11: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CHST11 Gene

Orthologs for CHST11 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CHST11 30 31
  • 99.9 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CHST11 31
  • 96 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CHST11 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia CHST11 30 31
  • 92.52 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CHST11 30 31
  • 91.48 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Chst11 30
  • 91.38 (n)
Mouse
(Mus musculus)
Mammalia Chst11 30 17 31
  • 91.1 (n)
OneToOne
Chicken
(Gallus gallus)
Aves CHST11 30 31
  • 84.94 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CHST11 31
  • 94 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia chst11 30
  • 78.87 (n)
Str.15300 30
African clawed frog
(Xenopus laevis)
Amphibia chst11-prov 30
Zebrafish
(Danio rerio)
Actinopterygii chst11 30 31
  • 75.57 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004371 30
  • 52.12 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG31743 30 31
  • 51.43 (n)
OneToMany
Species where no ortholog for CHST11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CHST11 Gene

ENSEMBL:
Gene Tree for CHST11 (if available)
TreeFam:
Gene Tree for CHST11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CHST11: view image

Paralogs for CHST11 Gene

Paralogs for CHST11 Gene

(6) SIMAP similar genes for CHST11 Gene using alignment to 4 proteins:

  • CHSTB_HUMAN
  • F8VRG6_HUMAN
  • F8VXK3_HUMAN
  • F8VXK7_HUMAN
genes like me logo Genes that share paralogs with CHST11: view

Variants for CHST11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CHST11 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs1566067709 Conflicting Interpretations: clino-symphalangism; overriding digits; Brachydactyly; Chondrodysplasia; OSTEOCHONDRODYSPLASIA, BRACHYDACTYLY, AND OVERLAPPING MALFORMED DIGITS; Synpolydactyly 1 104,757,221(+) CAACCTGAAGACCCTG INFRAME_DELETION

Additional dbSNP identifiers (rs#s) for CHST11 Gene

Structural Variations from Database of Genomic Variants (DGV) for CHST11 Gene

Variant ID Type Subtype PubMed ID
esv25429 CNV loss 19812545
esv26567 CNV loss 19812545
esv2661506 CNV deletion 23128226
esv2746317 CNV deletion 23290073
esv2746318 CNV deletion 23290073
esv3324510 CNV duplication 20981092
esv3630646 CNV loss 21293372
esv3630647 CNV loss 21293372
esv3630648 CNV loss 21293372
esv3630649 CNV loss 21293372
esv3892263 CNV loss 25118596
esv3892264 CNV loss 25118596
nsv1035364 CNV loss 25217958
nsv1042647 CNV loss 25217958
nsv1134259 CNV deletion 24896259
nsv1160060 CNV duplication 26073780
nsv473090 CNV novel sequence insertion 20440878
nsv474395 CNV novel sequence insertion 20440878
nsv478698 CNV novel sequence insertion 20440878
nsv515742 CNV loss 19592680
nsv560051 CNV gain 21841781
nsv832502 CNV loss 17160897
nsv832504 CNV gain+loss 17160897
nsv868 CNV deletion 18451855
nsv975527 CNV duplication 23825009

Variation tolerance for CHST11 Gene

Residual Variation Intolerance Score: 18.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHST11 Gene

Human Gene Mutation Database (HGMD)
CHST11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHST11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST11 Gene

Disorders for CHST11 Gene

MalaCards: The human disease database

(9) MalaCards diseases for CHST11 Gene - From: OMIM, GTR, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CHSTB_HUMAN
  • Note=A chromosomal aberration involving CHST11 is found in B-cell chronic lymphocytic leukemias. Translocation t(12;14)(q23;q32) with IgH. {ECO:0000269 PubMed:15273723}.
  • Osteochondrodysplasia, brachydactyly, and overlapping malformed digits (OCBMD) [MIM:618167]: An autosomal recessive disorder characterized by bilateral symmetric skeletal defects that primarily affect the limbs. Affected individuals have mild short stature due to shortening of the lower leg bones, as well as hand and foot malformations, predominantly brachydactyly and overlapping digits. Other skeletal defects include scoliosis, dislocated patellae and fibulae, and pectus excavatum. {ECO:0000269 PubMed:29514872}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CHST11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CHST11: view

No data available for Genatlas for CHST11 Gene

Publications for CHST11 Gene

  1. Deregulation of the carbohydrate (chondroitin 4) sulfotransferase 11 (CHST11) gene in a B-cell chronic lymphocytic leukemia with a t(12;14)(q23;q32). (PMID: 15273723) Schmidt HH … Chaganti RS (Oncogene 2004) 3 4 23
  2. Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis. (PMID: 12847091) Mikami T … Sugahara K (The Journal of biological chemistry 2003) 3 4 23
  3. Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family. (PMID: 10781601) Hiraoka N … Fukuda M (The Journal of biological chemistry 2000) 2 3 4
  4. Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase. (PMID: 11056388) Okuda T … Habuchi O (Journal of biochemistry 2000) 3 4 23
  5. Homozygous CHST11 mutation in chondrodysplasia, brachydactyly, overriding digits, clino-symphalangism and synpolydactyly. (PMID: 29514872) Shabbir RMK … Tolun A (Journal of medical genetics 2018) 3 4

Products for CHST11 Gene

  • Signalway Proteins for CHST11

Sources for CHST11 Gene