Aliases for CHST11 Gene
External Ids for CHST11 Gene
Previous GeneCards Identifiers for CHST11 Gene
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for CHST11 Gene
CHST11 (Carbohydrate Sulfotransferase 11) is a Protein Coding gene. Diseases associated with CHST11 include Osteochondrodysplasia, Brachydactyly, And Overlapping Malformed Digits and Synpolydactyly. Among its related pathways are Spinal Cord Injury and Glycosaminoglycan metabolism. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and chondroitin 4-sulfotransferase activity. An important paralog of this gene is CHST13.
UniProtKB/Swiss-Prot Summary for CHST11 Gene
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.