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This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity.[provided by RefSeq, Feb 2011]
CHST10 (Carbohydrate Sulfotransferase 10) is a Protein Coding gene. Diseases associated with CHST10 include Retinitis Pigmentosa 33 and Colon Lymphoma. Among its related pathways are Articular Cartilage Extracellular Matrix Pathway and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and HNK-1 sulfotransferase activity. An important paralog of this gene is CHST9.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008146 | sulfotransferase activity | IEA,IBA | 21873635 |
GO:0016232 | HNK-1 sulfotransferase activity | TAS | -- |
GO:0016740 | transferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IEA,TAS | -- |
GO:0005794 | Golgi apparatus | IEA,TAS | 9478973 |
GO:0016020 | membrane | IEA,TAS | 9478973 |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport to the Golgi and subsequent modification | ||
2 | Metabolism of proteins | ||
3 | N-glycan antennae elongation in the medial/trans-Golgi | ||
4 | Mannose type O-glycan biosynthesis | ||
5 | Metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005975 | carbohydrate metabolic process | IEA | -- |
GO:0007155 | cell adhesion | TAS | 9478973 |
GO:0016051 | carbohydrate biosynthetic process | IEA | -- |
GO:0030166 | proteoglycan biosynthetic process | IBA | 21873635 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
ExUns: | 12d | ^ | 13a | · | 13b | ^ | 14a | · | 14b |
---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||
SP2: | |||||||||
SP3: | |||||||||
SP4: | |||||||||
SP5: | |||||||||
SP6: | |||||||||
SP7: | |||||||||
SP8: | |||||||||
SP9: | |||||||||
SP10: | |||||||||
SP11: | |||||||||
SP12: | |||||||||
SP13: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CHST10 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | CHST10 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Chst10 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Chst10 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CHST10 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CHST10 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CHST10 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CHST10 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | chst10 30 |
|
||
Str.16232 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.8239 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | chst10 30 31 |
|
OneToOne | |
Dr.11834 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG14024 31 |
|
ManyToMany | |
CG13937 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs35177621 | - |
p.Val20Leu |
|||
rs3748932 | - |
p.Asp258Asn |
Disorder | Aliases | PubMed IDs |
---|---|---|
retinitis pigmentosa 33 |
|
|
colon lymphoma |
|
|
walker-warburg syndrome |
|
|