Aliases for CHST10 Gene
External Ids for CHST10 Gene
Previous GeneCards Identifiers for CHST10 Gene
This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity.[provided by RefSeq, Feb 2011]
GeneCards Summary for CHST10 Gene
CHST10 (Carbohydrate Sulfotransferase 10) is a Protein Coding gene. Diseases associated with CHST10 include Retinitis Pigmentosa 33 and Colon Lymphoma. Among its related pathways are Articular Cartilage Extracellular Matrix Pathway and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and HNK-1 sulfotransferase activity. An important paralog of this gene is CHST9.
UniProtKB/Swiss-Prot Summary for CHST10 Gene
Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis.