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This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011] See more...
Aliases for CHST1 Gene
Aliases for CHST1 Gene
External Ids for CHST1 Gene
- HGNC: 1969
- Entrez Gene: 8534
- Ensembl: ENSG00000175264
- OMIM: 603797
- UniProtKB: O43916
Previous GeneCards Identifiers for CHST1 Gene
- GC11M047454
- GC11M046360
- GC11M045702
- GC11M045634
- GC11M045627
- GC11M045378
- GC11M045670
Summaries for CHST1 Gene
-
This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011]
GeneCards Summary for CHST1 Gene
CHST1 (Carbohydrate Sulfotransferase 1) is a Protein Coding gene. Among its related pathways are Keratan sulfate/keratin metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and keratan sulfotransferase activity. An important paralog of this gene is CHST3.
UniProtKB/Swiss-Prot Summary for CHST1 Gene
-
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation.
Additional gene information for CHST1 Gene
- HGNC(1969)
- Entrez Gene(8534)
- Ensembl(ENSG00000175264)
- OMIM(603797)
- UniProtKB(O43916)
- Open Targets Platform(ENSG00000175264)
- Search for CHST1 at DataMed
- Search for CHST1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CHST1 Gene
Genomics for CHST1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CHST1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CHST1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CHST1
- Top Transcription factor binding sites by QIAGEN in the CHST1 gene promoter:
-
- AREB6
- C/EBPbeta
- HOXA5
- LCR-F1
- Lhx3a
- LHX3b
- Max
- NF-kappaB
- NF-kappaB1
- NF-kappaB2
Genomic Locations for CHST1 Gene
Genomic Locations for CHST1 Gene
- chr11:45,647,689-45,665,651
- (GRCh38/hg38)
- Size:
- 17,963 bases
- Orientation:
- Minus strand
- chr11:45,670,427-45,687,172
- (GRCh37/hg19)
- Size:
- 16,746 bases
- Orientation:
- Minus strand
Genomic View for CHST1 Gene
Genes around CHST1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by HGNC
- 11p11.2 by Entrez Gene
- 11p11.2 by Ensembl
CHST1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CHST1 Gene
Proteins for CHST1 Gene
-
Protein details for CHST1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43916-CHST1_HUMAN
- Recommended name:
- Carbohydrate sulfotransferase 1
- Protein Accession:
- O43916
- D3DQP2
Protein attributes for CHST1 Gene
- Size:
- 411 amino acids
- Molecular mass:
- 46715 Da
- Quaternary structure:
- No Data Available
Selected DME Specific Peptides for CHST1 Gene
- O43916:
-
- ETFRDTYRLWR
- SIAIQYTAIRTFTAK
- EDPRLNLKVIQLVRDPRGIL
- YMLVRYED
- DVFYLFEPLYHVQ
- CDLYFLE
- TGRKPYNLD
- RSGSSFVGQLF
- YMLVRYEDLARNP
- LVEDPRL
- RRVMLGASRDLLRSLY
Post-translational modifications for CHST1 Gene
Other Protein References for CHST1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CHST1 Antibody
- Novus Biologicals Antibodies for CHST1
- Invitrogen Antibodies for CHST1 (AFLGC-CHST1)
-
Boster Bio Antibodies for CHST1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CHST1
Protein Products
-
OriGene Purified Proteins for CHST1
- Search Origene for MassSpec and Protein Over-expression Lysates for CHST1
- Origene Custom Protein Services for CHST1
- Novus Biologicals lysates for CHST1
-
Abcam proteins for CHST1
Assay Products
- RayBiotech Custom Human CHST1 ELISA
- antibodies-online: Show 6 available CHST1 Elisa Kits ranked by validation data
- Compare Top CHST1 Elisa Kits
-
Quality Products:
Domains & Families for CHST1 Gene
Gene Families for CHST1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for CHST1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CHST1 Gene
- GenScript: Design optimal peptide antigens:
-
- Keratan sulfate Gal-6 sulfotransferase (CHST1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O43916UniProtKB/Swiss-Prot:
CHST1_HUMAN :- Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
- Family:
-
- Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
Function for CHST1 Gene
Molecular function for CHST1 Gene
- UniProtKB/Swiss-Prot Function:
- Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate.; EC=2.8.2.21; Evidence={ECO:0000269|PubMed:9405439};.
- GENATLAS Biochemistry:
- chondroitin 6-sulfotransferase key enzyme 1,expressed in vascular endothelial cells,implicated in chondrogenesis,neoplasia,atherosclerosis and other
Enzyme Numbers (IUBMB) for CHST1 Gene
Phenotypes From GWAS Catalog for CHST1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity | IBA | 21873635 |
| GO:0008146 | sulfotransferase activity | IDA | 10330415 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0045130 | keratan sulfotransferase activity | TAS | -- |
Phenotypes for CHST1 Gene
- MGI mutant phenotypes for CHST1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CHST1:
-
- Decreased hepcidin::fluc mRNA expression
- no effect
- Dynamic nuclei (hole, folded or small irregular)
- Decreased viability ratio
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased POU5F1-GFP protein expression
- Mitotic spindle defects
- Decreased HIV-1 infection
Animal Models for CHST1 Gene
- MGI Knock Outs for CHST1:
-
- Chst1 Chst1<tm1(KOMP)Vlcg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CHST1 - Select products 50% OFF >
- * CHST1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CHST1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CHST1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHST1
miRNA for CHST1 Gene
- miRTarBase miRNAs that target CHST1
-
- mmu-miR-301b-3p (MIRT007789)
- mmu-miR-19b-3p (MIRT012405)
- mmu-miR-129-5p (MIRT594142)
- mmu-miR-182-5p (MIRT594143)
- mmu-miR-96-5p (MIRT594144)
- hsa-miR-1273f (MIRT736792)
- hsa-miR-1273h-5p (MIRT736856)
- hsa-miR-149-3p (MIRT737713)
- hsa-miR-1827 (MIRT738090)
- hsa-miR-1910-3p (MIRT738395)
- hsa-miR-2467-3p (MIRT739253)
- hsa-miR-25-3p (MIRT739353)
- hsa-miR-30b-3p (MIRT739746)
- hsa-miR-3192-5p (MIRT741009)
- hsa-miR-32-5p (MIRT741247)
- hsa-miR-3612 (MIRT741555)
- hsa-miR-363-3p (MIRT741798)
- hsa-miR-367-3p (MIRT742114)
- hsa-miR-3689a-3p (MIRT742248)
- hsa-miR-3689b-3p (MIRT742318)
- hsa-miR-3689c (MIRT742388)
- hsa-miR-377-5p (MIRT742677)
- hsa-miR-4257 (MIRT743391)
- hsa-miR-4325 (MIRT744079)
- hsa-miR-4537 (MIRT746082)
- hsa-miR-455-3p (MIRT746168)
- hsa-miR-4728-5p (MIRT747809)
- hsa-miR-490-3p (MIRT749167)
- hsa-miR-508-5p (MIRT749612)
- hsa-miR-566 (MIRT751116)
- hsa-miR-6086 (MIRT751831)
- hsa-miR-6499-3p (MIRT752784)
- hsa-miR-650 (MIRT753003)
- hsa-miR-6511a-5p (MIRT753120)
- hsa-miR-6512-3p (MIRT753216)
- hsa-miR-6516-5p (MIRT753331)
- hsa-miR-652-3p (MIRT753409)
- hsa-miR-6720-5p (MIRT753748)
- hsa-miR-6779-5p (MIRT755487)
- hsa-miR-6780a-5p (MIRT755563)
- hsa-miR-6785-5p (MIRT755804)
- hsa-miR-6789-3p (MIRT756005)
- hsa-miR-6799-5p (MIRT756291)
- hsa-miR-6849-3p (MIRT757535)
- hsa-miR-6883-5p (MIRT758389)
- hsa-miR-7106-5p (MIRT758841)
- hsa-miR-766-3p (MIRT759605)
- hsa-miR-7703 (MIRT759709)
- hsa-miR-7851-3p (MIRT759884)
- hsa-miR-92a-3p (MIRT760617)
- hsa-miR-92b-3p (MIRT760645)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CHST1
- Browse OriGene Inhibitory RNA Products For CHST1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHST1
Clone Products
- Applied Biological Materials (abm): Clones for CHST1 - Select products 50% OFF >
- * CHST1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CHST1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CHST1
Cell Line Products
-
Horizon Cell Lines for CHST1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHST1 Gene
Localization for CHST1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CHST1 Gene
- Golgi apparatus membrane. Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 4 |
| extracellular | 3 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
| mitochondrion | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005802 | trans-Golgi network | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | TAS,NAS | 9405439 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CHST1 Gene
Pathways & Interactions for CHST1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Keratan sulfate/keratin metabolism | ||
| 2 | Glycosaminoglycan metabolism | ||
| 3 | Articular Cartilage Extracellular Matrix | ||
| 4 | Metabolism |
.40
|
|
| 5 | Cytochrome P450 - arranged by substrate type | ||
Pathways by source for CHST1 Gene
1 BioSystems pathway for CHST1 Gene
5 Reactome pathways for CHST1 Gene
1 KEGG pathway for CHST1 Gene
1 R&D Systems pathway for CHST1 Gene
Interacting Proteins for CHST1 Gene
Selected Interacting proteins:
O43916-CHST1_HUMAN
ENSP00000309270
for CHST1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CHST1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | IEA | -- |
| GO:0005976 | polysaccharide metabolic process | TAS | 9405439 |
| GO:0006012 | galactose metabolic process | IDA | 10330415 |
| GO:0006044 | N-acetylglucosamine metabolic process | IBA | 21873635 |
| GO:0006790 | sulfur compound metabolic process | IBA,IDA | 10330415 |
No data available for SIGNOR curated interactions for CHST1 Gene
Drugs & Compounds for CHST1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Keratan |
|
69992-87-6 |
|
|||
| n-acetyllactosamine |
|
32181-59-2 |
|
Transcripts for CHST1 Gene
mRNA/cDNA for CHST1 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000308064 3906 nts (view in UCSC)
- ENST00000533673 516 nts (view in UCSC)
- ENST00000531322 1361 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CHST1 - Select products 50% OFF >
- * CHST1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CHST1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CHST1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHST1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CHST1
- Browse OriGene Inhibitory RNA Products For CHST1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHST1
Clone Products
- Applied Biological Materials (abm): Clones for CHST1 - Select products 50% OFF >
- * CHST1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CHST1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CHST1
Relevant External Links for CHST1 Gene
- GeneLoc Exon Structure for
- CHST1
Expression for CHST1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
- Retina
- Lens
- Neural Tube (Nervous System)
- Epiblast (Early Embryonic Tissues)
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Testis (Reproductive System)
- Secondary Spermatocyte Seminiferous Tubules
-
Gonad
- Secondary Spermatocyte Seminiferous Tubules
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
- Brain (Nervous System)
- Kidney (Urinary System)
- Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for CHST1 Gene
This gene is overexpressed in Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.6), and Brain - Amygdala (x4.0).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CHST1
SOURCE GeneReport for Unigene cluster for CHST1 Gene:
Hs.104576mRNA Expression by UniProt/SwissProt for CHST1 Gene:
O43916-CHST1_HUMAN
Tissue specificity:
Widely expressed at low level. Expressed in brain and skeletal muscle. Expressed by high endothelial cells (HEVs) and leukocytes.
Evidence on tissue expression from TISSUES for CHST1 Gene
- Nervous system(4.7)
- Heart(4.2)
Primer Products
-
OriGene qPCR primer pairs for CHST1
-
OriGene qPCR primer pairs and template standards for CHST1
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHST1 Gene
Orthologs for CHST1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CHST1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CHST1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CHST1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Chst1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | CHST1 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Chst1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CHST1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CHST1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CHST1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | chst1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | chst1 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG9550 31 |
|
ManyToMany | |
| CG31637 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| CSA.5535 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany |
- Species where no ortholog for CHST1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CHST1 Gene
- ENSEMBL:
- Gene Tree for CHST1 (if available)
- TreeFam:
- Gene Tree for CHST1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CHST1: view image
Paralogs for CHST1 Gene
Variants for CHST1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CHST1 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 691422 | Uncertain Significance: Pyloric stenosis; Esophageal atresia | 45,649,909(-) | C/T | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
12.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.17;
23.61% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CHST1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CHST1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST1 Gene
Disorders for CHST1 Gene
Additional Disease Information for CHST1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for CHST1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHST1 Gene
Publications for CHST1 Gene
- Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization. (PMID: 9639683) Mazany KD … Williams KJ (Biochimica et biophysica acta 1998) 2 3 4 23
- Molecular cloning and characterization of human keratan sulfate Gal-6-sulfotransferase. (PMID: 9405439) Fukuta M … Habuchi O (The Journal of biological chemistry 1997) 2 3 4 23
- CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin. (PMID: 11310842) Li X … Tedder TF (Journal of leukocyte biology 2001) 3 4 23
- Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase. (PMID: 10642612) Torii T … Habuchi O (Glycobiology 2000) 3 4 23
- CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization. (PMID: 10049591) Li X … Tedder TF (Genomics 1999) 3 4 23
ExternalLinks
Products for CHST1 Gene
- View all 4 R&D Systems CHST1 (Carbohydrate Sulfotransferase 1/CHST1) Products
- View all R&D Systems CHST1 (Carbohydrate Sulfotransferase 1/CHST1) Proteins and Enzymes
- View all 3 R&D Systems CHST1 (Carbohydrate Sulfotransferase 1/CHST1) Primary Antibodies
- Learn more about R&D Systems custom CHST1 antibody, protein, and immunoassay development services
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CHST1
- Search Origene for MassSpec and Protein Over-expression Lysates for CHST1
- Origene Custom Protein Services for CHST1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CHST1
- Browse OriGene Inhibitory RNA Products For CHST1
- OriGene qPCR primer pairs for CHST1
- OriGene qPCR primer pairs and template standards for CHST1
- OriGene CRISPR knockouts for CHST1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CHST1
- Sino Biological Human cDNA Clone for CHST1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CHST1
- Novus Biologicals lysates for CHST1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for CHST1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for CHST1 (AFLGC-CHST1)
- VectorBuilder Custom and pre-made DNA vectors for CHST1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CHST1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CHST1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CHST1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CHST1
- antibodies-online: Show 15 available CHST1 Antibodies ranked by validation data
- Compare Top CHST1 Antibodies
- antibodies-online: Show 6 available CHST1 Elisa Kits ranked by validation data
- Compare Top CHST1 Elisa Kits
- Quality Products:
- antibodies-online: Show 5 available CHST1 Proteins ranked by validation data
- Compare Top CHST1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CHST1
- Search Santa Cruz Biotechnology (SCBT) for CHST1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CHST1
- Horizon Cell Lines for CHST1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CHST1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CHST1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CHST1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHST1
- Boster Bio Antibodies for CHST1
- Browse Boster Bio ELISA Kits
Sources for CHST1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB