Aliases for CHST1 Gene
External Ids for CHST1 Gene
Previous GeneCards Identifiers for CHST1 Gene
This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011]
GeneCards Summary for CHST1 Gene
CHST1 (Carbohydrate Sulfotransferase 1) is a Protein Coding gene. Among its related pathways are Articular Cartilage Extracellular Matrix Pathway and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and keratan sulfotransferase activity. An important paralog of this gene is CHST3.
UniProtKB/Swiss-Prot Summary for CHST1 Gene
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation.