Aliases for CHRNB2 Gene
External Ids for CHRNB2 Gene
Previous GeneCards Identifiers for CHRNB2 Gene
Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008]
GeneCards Summary for CHRNB2 Gene
CHRNB2 (Cholinergic Receptor Nicotinic Beta 2 Subunit) is a Protein Coding gene. Diseases associated with CHRNB2 include Epilepsy, Nocturnal Frontal Lobe, 3 and Autosomal Dominant Nocturnal Frontal Lobe Epilepsy. Among its related pathways are Nicotine addiction and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and extracellular ligand-gated ion channel activity. An important paralog of this gene is CHRNB4.
UniProtKB/Swiss-Prot Summary for CHRNB2 Gene
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.
Nicotinic alpha4beta2 receptors have high affinity for nicotine and account for >90% of [3H]-nicotine binding to brain tissues. A stoichiometry of (alpha4)2(beta2)3 has been proposed, generating two agonist binding sites consistent with the model of the muscle nAChR.