Aliases for CHRNA3 Gene
External Ids for CHRNA3 Gene
Previous GeneCards Identifiers for CHRNA3 Gene
This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]
GeneCards Summary for CHRNA3 Gene
CHRNA3 (Cholinergic Receptor Nicotinic Alpha 3 Subunit) is a Protein Coding gene. Diseases associated with CHRNA3 include Smoking As A Quantitative Trait Locus 3 and Autosomal Dominant Nocturnal Frontal Lobe Epilepsy. Among its related pathways are Circadian entrainment and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include extracellular ligand-gated ion channel activity and ligand-gated ion channel activity. An important paralog of this gene is CHRNA6.
UniProtKB/Swiss-Prot for CHRNA3 Gene
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.