Aliases for CHRNA10 Gene

Aliases for CHRNA10 Gene

  • Cholinergic Receptor Nicotinic Alpha 10 Subunit 2 3 5
  • Acetylcholine Receptor, Nicotinic, Alpha 10 (Neuronal) 2 3
  • Cholinergic Receptor, Nicotinic, Alpha Polypeptide 10 2 3
  • Cholinergic Receptor, Nicotinic, Alpha 10 (Neuronal) 2 3
  • Nicotinic Acetylcholine Receptor Subunit Alpha-10 3 4
  • Neuronal Acetylcholine Receptor Subunit Alpha-10 3 4
  • Cholinergic Receptor, Nicotinic Alpha 10 2 3
  • NACHR Alpha-10 3 4
  • NACHRA10 4
  • CHRNA10 5

External Ids for CHRNA10 Gene

Previous GeneCards Identifiers for CHRNA10 Gene

  • GC11M004258
  • GC11M003952
  • GC11M003646
  • GC11M003651
  • GC11M003644
  • GC11M003645
  • GC11M003649
  • GC11M003654
  • GC11M003687
  • GC11M003420
  • GC11M003688
  • GC11M003691
  • GC11M003699

Summaries for CHRNA10 Gene

GeneCards Summary for CHRNA10 Gene

CHRNA10 (Cholinergic Receptor Nicotinic Alpha 10 Subunit) is a Protein Coding gene. Diseases associated with CHRNA10 include Tobacco Addiction. Among its related pathways are Nanog in Mammalian ESC Pluripotency and CREB Pathway. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and extracellular ligand-gated ion channel activity. An important paralog of this gene is CHRNA9.

UniProtKB/Swiss-Prot Summary for CHRNA10 Gene

  • Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

Gene Wiki entry for CHRNA10 Gene

Additional gene information for CHRNA10 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CHRNA10 Gene

Genomics for CHRNA10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CHRNA10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J003673 Enhancer 0.4 Ensembl ENCODE 600.7 -0.9 -895 1.4 FOS CHRNA10 ART5 lnc-CHRNA10-1 NUP98 PGAP2
GH11J003679 Promoter 0.3 EPDnew 600.4 -6.1 -6055 0.1 CHRNA10 lnc-CHRNA10-1 piR-60030 NUP98 PGAP2
GH11J003830 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.6 -162.9 -162908 12.9 GATAD2A CTCF TFE3 ZNF512 LEF1 IKZF1 ZNF692 POLR2A BACH1 ETV6 RHOG NUP98 RRM1 ENSG00000206976 ART1 ART5 CHRNA10 STIM1 PPIAP40 ENSG00000236710
GH11J003824 Enhancer 1.1 ENCODE dbSUPER 9.6 -152.5 -152527 3.2 CTCF TEAD4 ZNF629 IKZF1 POLR2A JUND DDX20 ZNF143 HNRNPUL1 ZNF24 NUP98 OSBPL5 RRM1 ART1 ART5 CHRNA10 lnc-RHOG-1 RHOG PGAP2
GH11J003721 Enhancer 0.8 Ensembl ENCODE 10.6 -49.4 -49369 2.8 CEBPB SP1 JUND FOS FOSL2 SIN3A BHLHE40 JUN MYC MAX lnc-CHRNA10-3 NUP98 RNU7-50P CHRNA10 ART5 lnc-CHRNA10-4 PGAP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CHRNA10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CHRNA10

Top Transcription factor binding sites by QIAGEN in the CHRNA10 gene promoter:
  • AP-4
  • CP2
  • En-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXL1
  • HEN1
  • MIF-1
  • p53

Genomic Locations for CHRNA10 Gene

Genomic Locations for CHRNA10 Gene
chr11:3,665,587-3,673,629
(GRCh38/hg38)
Size:
8,043 bases
Orientation:
Minus strand
chr11:3,686,817-3,692,614
(GRCh37/hg19)
Size:
5,798 bases
Orientation:
Minus strand

Genomic View for CHRNA10 Gene

Genes around CHRNA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHRNA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHRNA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRNA10 Gene

Proteins for CHRNA10 Gene

  • Protein details for CHRNA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZZ6-ACH10_HUMAN
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-10
    Protein Accession:
    Q9GZZ6

    Protein attributes for CHRNA10 Gene

    Size:
    450 amino acids
    Molecular mass:
    49705 Da
    Quaternary structure:
    • Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 heterooligomers. Interacts with the conotoxin GeXXA (PubMed:26395518). Interacts with the alpha-conotoxin RgIA (By similarity).
    Miscellaneous:
    • The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).

neXtProt entry for CHRNA10 Gene

Post-translational modifications for CHRNA10 Gene

  • Glycosylation at Asn40 and Asn56
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRNA10 Gene

No data available for DME Specific Peptides for CHRNA10 Gene

Domains & Families for CHRNA10 Gene

Gene Families for CHRNA10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CHRNA10 Gene

InterPro:
Blocks:
  • Nicotinic acetylcholine receptor signature
  • Neurotransmitter-gated ion-channel
ProtoNet:

Suggested Antigen Peptide Sequences for CHRNA10 Gene

GenScript: Design optimal peptide antigens:
  • Nicotinic acetylcholine receptor subunit alpha-10 (ACH10_HUMAN)
  • CHRNA10 protein (C4IXS7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZZ6

UniProtKB/Swiss-Prot:

ACH10_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily.
genes like me logo Genes that share domains with CHRNA10: view

Function for CHRNA10 Gene

Molecular function for CHRNA10 Gene

UniProtKB/Swiss-Prot Function:
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

Gene Ontology (GO) - Molecular Function for CHRNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005102 signaling receptor binding TAS 11350119
GO:0005216 ion channel activity IEA --
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005262 calcium channel activity IEA --
genes like me logo Genes that share ontologies with CHRNA10: view
genes like me logo Genes that share phenotypes with CHRNA10: view

Animal Models for CHRNA10 Gene

MGI Knock Outs for CHRNA10:

Animal Model Products

  • Taconic Biosciences Mouse Models for CHRNA10

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHRNA10

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CHRNA10 Gene

Localization for CHRNA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRNA10 Gene

Cell junction, synapse, postsynaptic cell membrane. Multi-pass membrane protein. Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHRNA10 gene
Compartment Confidence
plasma membrane 4
extracellular 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CHRNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane TAS 11350119
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CHRNA10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CHRNA10 Gene

Pathways & Interactions for CHRNA10 Gene

PathCards logo

SuperPathways for CHRNA10 Gene

SuperPathway Contained pathways
1 Peptide ligand-binding receptors
2 Nanog in Mammalian ESC Pluripotency
.48
3 CREB Pathway
.50
genes like me logo Genes that share pathways with CHRNA10: view

Pathways by source for CHRNA10 Gene

1 KEGG pathway for CHRNA10 Gene
2 Qiagen pathways for CHRNA10 Gene
  • eNOS Signaling
  • Intracellular Calcium Signaling

Gene Ontology (GO) - Biological Process for CHRNA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport IEA --
GO:0007165 signal transduction IBA 21873635
GO:0007204 positive regulation of cytosolic calcium ion concentration IGI 18420419
GO:0007268 chemical synaptic transmission IBA 21873635
genes like me logo Genes that share ontologies with CHRNA10: view

No data available for SIGNOR curated interactions for CHRNA10 Gene

Drugs & Compounds for CHRNA10 Gene

(20) Drugs for CHRNA10 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotine Approved Pharma Antagonist, Activator, Activation, Target, agonist, antagonist 1518
Pentolinium Approved Pharma Target, antagonist 0
Trimethaphan Approved, Investigational Pharma Target, antagonist 10
Ethanol Approved Pharma Target 3266
Succinylcholine Approved Pharma Agonist, Full agonist, Target, agonist 69

(1) ApexBio Compounds for CHRNA10 Gene

Compound Action Cas Number
ACV 1 740980-24-9
genes like me logo Genes that share compounds with CHRNA10: view

Drug Products

Transcripts for CHRNA10 Gene

mRNA/cDNA for CHRNA10 Gene

3 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHRNA10

Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA10 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5
SP1: - -
SP2:

Relevant External Links for CHRNA10 Gene

GeneLoc Exon Structure for
CHRNA10

Expression for CHRNA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHRNA10 Gene

mRNA differential expression in normal tissues according to GTEx for CHRNA10 Gene

This gene is overexpressed in Muscle - Skeletal (x18.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CHRNA10

SOURCE GeneReport for Unigene cluster for CHRNA10 Gene:

Hs.732806

mRNA Expression by UniProt/SwissProt for CHRNA10 Gene:

Q9GZZ6-ACH10_HUMAN
Tissue specificity: Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.

Evidence on tissue expression from TISSUES for CHRNA10 Gene

  • Muscle(4.4)
genes like me logo Genes that share expression patterns with CHRNA10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHRNA10 Gene

Orthologs for CHRNA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRNA10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CHRNA10 30 31
  • 99.33 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CHRNA10 30 31
  • 91.16 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Chrna10 30 17 31
  • 86.06 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Chrna10 30
  • 85.16 (n)
Oppossum
(Monodelphis domestica)
Mammalia CHRNA10 31
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CHRNA10 31
  • 63 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia CHRNA10 31
  • 54 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CHRNA10 30 31
  • 71.04 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 62 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia chrna10 30
  • 64.95 (n)
Zebrafish
(Danio rerio)
Actinopterygii chrna10a 30
  • 61.04 (n)
CR847523.1 31
  • 52 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta nAcRbeta-21C 31
  • 25 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea acr-21 30
  • 48.91 (n)
acr-7 32
  • 38 (a)
F18G5.4 32
  • 35 (a)
deg-3 32
  • 33 (a)
acr-22 32
  • 31 (a)
acr-5 32
  • 30 (a)
acr-17 32
  • 30 (a)
Y73F8A.30 32
  • 30 (a)
acr-18 32
  • 28 (a)
C04C3.2 32
  • 28 (a)
lgc-5 31
  • 23 (a)
ManyToMany
Species where no ortholog for CHRNA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CHRNA10 Gene

ENSEMBL:
Gene Tree for CHRNA10 (if available)
TreeFam:
Gene Tree for CHRNA10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CHRNA10: view image

Paralogs for CHRNA10 Gene

(19) SIMAP similar genes for CHRNA10 Gene using alignment to 4 proteins:

  • ACH10_HUMAN
  • C4IXS7_HUMAN
  • E9PNT7_HUMAN
  • E9PNX2_HUMAN
genes like me logo Genes that share paralogs with CHRNA10: view

Variants for CHRNA10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CHRNA10 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs2231547 - p.Glu355Ala

Additional dbSNP identifiers (rs#s) for CHRNA10 Gene

Structural Variations from Database of Genomic Variants (DGV) for CHRNA10 Gene

Variant ID Type Subtype PubMed ID
esv2759796 CNV gain+loss 17122850
esv3625147 CNV gain 21293372
esv3625148 CNV gain 21293372
nsv1046356 CNV gain 25217958
nsv428247 CNV loss 18775914
nsv482156 CNV loss 20164927
nsv526441 CNV gain 19592680
nsv832051 CNV gain 17160897
nsv832052 CNV loss 17160897

Variation tolerance for CHRNA10 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.47; 64.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHRNA10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHRNA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRNA10 Gene

Disorders for CHRNA10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CHRNA10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
tobacco addiction
  • tobacco addiction, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CHRNA10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CHRNA10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHRNA10 Gene

Publications for CHRNA10 Gene

  1. Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (PMID: 17559419) Rigbi A … Lerer B (Genes, brain, and behavior 2008) 3 23 41
  2. Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10). (PMID: 11350119) Lustig LR … Fuchs PA (Genomics 2001) 3 4 23
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 41
  5. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (PMID: 20584212) Saccone NL … Bierut LJ (Genes, brain, and behavior 2010) 3 41

Products for CHRNA10 Gene

  • Biorbyt antibodies for CHRNA10

Sources for CHRNA10 Gene