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Aliases for CHRM5 Gene

Aliases for CHRM5 Gene

  • Cholinergic Receptor Muscarinic 5 2 3 5
  • Acetylcholine Receptor, Muscarinic 5 2 3
  • Muscarinic Acetylcholine Receptor M5 3
  • HM5 3

External Ids for CHRM5 Gene

Previous GeneCards Identifiers for CHRM5 Gene

  • GC15P029591
  • GC15P027026
  • GC15P031889
  • GC15P032070
  • GC15P031977
  • GC15P032097
  • GC15P032048
  • GC15P034261
  • GC15P011124

Summaries for CHRM5 Gene

Entrez Gene Summary for CHRM5 Gene

  • The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHRM5 Gene

CHRM5 (Cholinergic Receptor Muscarinic 5) is a Protein Coding gene. Among its related pathways are Monoamine GPCRs and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled acetylcholine receptor activity. An important paralog of this gene is CHRM3.

UniProtKB/Swiss-Prot for CHRM5 Gene

  • The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Tocris Summary for CHRM5 Gene

  • Muscarinic receptors are widely distributed throughout the body and control distinct functions according to location and subtype (M1 - M5).They are predominantly expressed in the parasympathetic nervous system where they exert both inhibitory and excitatory effects.

Gene Wiki entry for CHRM5 Gene

Additional gene information for CHRM5 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRM5 Gene

Genomics for CHRM5 Gene

GeneHancer (GH) Regulatory Elements for CHRM5 Gene

Promoters and enhancers for CHRM5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J034046 Promoter/Enhancer 1.5 EPDnew ENCODE 658.9 +79.9 79884 3.4 PKNOX1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 E2F8 FOS ATF7 CHRM5 AVEN GC15M034069 ENSG00000259505
GH15J033984 Enhancer 0.8 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +17.2 17198 1.4 NUTM1 CHRM5 AVEN ENSG00000259505 ENSG00000278472
GH15J033971 Enhancer 0.6 FANTOM5 dbSUPER 6.5 +3.8 3762 0.3 POLR2A CREB1 ENSG00000278472 CHRM5 NUTM1 AVEN
GH15J033991 Enhancer 0.3 dbSUPER 11.4 +23.6 23603 1.3 ATF2 ENSG00000259505 CHRM5 AVEN GC15M034069
GH15J034011 Enhancer 0.2 ENCODE 8.4 +43.5 43498 1 CHRM5 ENSG00000259505 GC15M034069 AVEN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CHRM5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CHRM5 gene promoter:
  • FOXC1
  • TFIID
  • TBP
  • CUTL1
  • Nkx6-1
  • FOXJ2 (long isoform)
  • FOXJ2
  • Cart-1
  • POU2F1

Genomic Locations for CHRM5 Gene

Genomic Locations for CHRM5 Gene
chr15:33,968,245-34,067,457
(GRCh38/hg38)
Size:
99,213 bases
Orientation:
Plus strand
chr15:34,260,921-34,357,291
(GRCh37/hg19)
Size:
96,371 bases
Orientation:
Plus strand

Genomic View for CHRM5 Gene

Genes around CHRM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHRM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHRM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRM5 Gene

Proteins for CHRM5 Gene

  • Protein details for CHRM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08912-ACM5_HUMAN
    Recommended name:
    Muscarinic acetylcholine receptor M5
    Protein Accession:
    P08912
    Secondary Accessions:
    • Q96RG7

    Protein attributes for CHRM5 Gene

    Size:
    532 amino acids
    Molecular mass:
    60074 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHRM5 Gene

Post-translational modifications for CHRM5 Gene

  • Glycosylation at posLast=88
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRM5 Gene

No data available for DME Specific Peptides for CHRM5 Gene

Domains & Families for CHRM5 Gene

Gene Families for CHRM5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CHRM5 Gene

Graphical View of Domain Structure for InterPro Entry

P08912

UniProtKB/Swiss-Prot:

ACM5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.
genes like me logo Genes that share domains with CHRM5: view

Function for CHRM5 Gene

Molecular function for CHRM5 Gene

UniProtKB/Swiss-Prot Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
GENATLAS Biochemistry:
cholinergic receptor,muscarinic 5,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for CHRM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS 1905013
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0016907 G-protein coupled acetylcholine receptor activity IBA --
genes like me logo Genes that share ontologies with CHRM5: view
genes like me logo Genes that share phenotypes with CHRM5: view

Animal Models for CHRM5 Gene

MGI Knock Outs for CHRM5:

Animal Model Products

  • Taconic Biosciences Mouse Models for CHRM5

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHRM5

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CHRM5 Gene

Localization for CHRM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRM5 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHRM5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CHRM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CHRM5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CHRM5 Gene

Pathways & Interactions for CHRM5 Gene

genes like me logo Genes that share pathways with CHRM5: view

Gene Ontology (GO) - Biological Process for CHRM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001696 gastric acid secretion IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway TAS 8663391
GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with CHRM5: view

No data available for SIGNOR curated interactions for CHRM5 Gene

Drugs & Compounds for CHRM5 Gene

(133) Drugs for CHRM5 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atropine Approved, Vet_approved Pharma Antagonist, antagonist, Target MAChRs antagonist 153
Darifenacin Approved, Investigational Pharma Antagonist, Inverse agonist, antagonist, Target M3 receptor antagonist and antimuscarinic agents 22
Fesoterodine Approved Pharma Target, antagonist 64
Doxepin Approved, Investigational Pharma Antagonist, inhibitor, Target, antagonist 14
Methotrimeprazine Approved, Investigational Pharma Target, antagonist 8

(5) Additional Compounds for CHRM5 Gene - From: HMDB and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(-)aceclidine
Partial agonist, Agonist
(+)aceclidine
Full agonist, Agonist
HHSiD
Antagonist
N-Dealkylated tolterodine
Promazine 5-sulfoxide

(2) Tocris Compounds for CHRM5 Gene

Compound Action Cas Number
VU 0238429 Selective positive allosteric modulator of M5 receptors 1160247-92-6
VU 0365114 Positive allosteric modulator of M5 receptors 1208222-39-2
genes like me logo Genes that share compounds with CHRM5: view

Transcripts for CHRM5 Gene

mRNA/cDNA for CHRM5 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHRM5 Gene

Cholinergic receptor, muscarinic 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHRM5

Alternative Splicing Database (ASD) splice patterns (SP) for CHRM5 Gene

No ASD Table

Relevant External Links for CHRM5 Gene

GeneLoc Exon Structure for
CHRM5
ECgene alternative splicing isoforms for
CHRM5

Expression for CHRM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHRM5 Gene

mRNA differential expression in normal tissues according to GTEx for CHRM5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x16.2), Brain - Substantia nigra (x6.2), and Brain - Hypothalamus (x5.1).

Protein differential expression in normal tissues from HIPED for CHRM5 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CHRM5 Gene



Protein tissue co-expression partners for CHRM5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHRM5 Gene:

CHRM5

SOURCE GeneReport for Unigene cluster for CHRM5 Gene:

Hs.584747

Evidence on tissue expression from TISSUES for CHRM5 Gene

  • Nervous system(4.2)
  • Eye(4)
  • Skin(4)
genes like me logo Genes that share expression patterns with CHRM5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHRM5 Gene

Orthologs for CHRM5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHRM5 34 33
  • 99.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CHRM5 34 33
  • 90.29 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CHRM5 34 33
  • 90.23 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chrm5 33
  • 88.45 (n)
mouse
(Mus musculus)
Mammalia Chrm5 16 34 33
  • 88.16 (n)
oppossum
(Monodelphis domestica)
Mammalia CHRM5 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHRM5 34 33
  • 72.5 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHRM5 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chrm5 33
  • 70.25 (n)
zebrafish
(Danio rerio)
Actinopterygii chrm5a 34 33
  • 64.28 (n)
OneToMany
chrm5b 34
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7918 35
  • 35 (a)
mAcR-60C 34 35
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gar-3 34
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToMany
Species where no ortholog for CHRM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHRM5 Gene

ENSEMBL:
Gene Tree for CHRM5 (if available)
TreeFam:
Gene Tree for CHRM5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CHRM5: view image

Paralogs for CHRM5 Gene

Paralogs for CHRM5 Gene

(8) SIMAP similar genes for CHRM5 Gene using alignment to 4 proteins:

  • ACM5_HUMAN
  • H0YKC0_HUMAN
  • Q6NUM3_HUMAN
  • Q8IVW0_HUMAN
genes like me logo Genes that share paralogs with CHRM5: view

Variants for CHRM5 Gene

Sequence variations from dbSNP and Humsavar for CHRM5 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000006925 -- 34,053,653(+) CCTTATACCTTATAC/CCTTATAC intron_variant
rs1000033054 -- 33,979,250(+) G/A intron_variant
rs1000089211 -- 33,996,366(+) A/G intron_variant
rs1000113118 -- 33,974,018(+) A/G intron_variant
rs1000114881 -- 34,003,465(+) T/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CHRM5 Gene

Variant ID Type Subtype PubMed ID
dgv310n27 CNV loss 19166990
dgv4456n54 CNV gain 21841781
dgv447e214 CNV gain 21293372
esv2761666 CNV loss 21179565
esv33337 CNV gain+loss 17666407
esv3569431 CNV gain 25503493
esv3581622 CNV loss 25503493
esv3636098 CNV loss 21293372
nsv1044844 CNV loss 25217958
nsv1052620 CNV gain 25217958
nsv1069850 CNV deletion 25765185
nsv1131177 CNV deletion 24896259
nsv1131178 CNV deletion 24896259
nsv1143777 CNV deletion 24896259
nsv1151641 CNV deletion 26484159
nsv456789 CNV gain 19166990
nsv456790 CNV loss 19166990
nsv471235 CNV gain 18288195
nsv516347 CNV loss 19592680
nsv568920 CNV gain 21841781
nsv568923 CNV loss 21841781
nsv568924 CNV loss 21841781

Variation tolerance for CHRM5 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHRM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHRM5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRM5 Gene

Disorders for CHRM5 Gene

Additional Disease Information for CHRM5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CHRM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHRM5 Gene

Publications for CHRM5 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. (PMID: 19944766) Meda SA … Pearlson GD (NeuroImage 2010) 3 44 58
  4. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M … van Ree JM (Biological psychiatry 2009) 3 44 58
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 44 58

Products for CHRM5 Gene

Sources for CHRM5 Gene

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