CHRM4 Gene (Protein Coding)

Cholinergic Receptor Muscarinic 4

GC11M066224
GIFtS:
46
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in ... See more...

Aliases for CHRM4 Gene

Aliases for CHRM4 Gene

  • Cholinergic Receptor Muscarinic 4 2 3 5
  • Acetylcholine Receptor, Muscarinic 4 2 3
  • Muscarinic Acetylcholine Receptor M4 3 4
  • CHRM4 5
  • HM4 3
  • M4R 3

External Ids for CHRM4 Gene

Previous GeneCards Identifiers for CHRM4 Gene

  • GC11M048191
  • GC11M047097
  • GC11M046438
  • GC11M046370
  • GC11M046363
  • GC11M046113
  • GC11M046406
  • GC11M047073
  • GC11M047919
  • GC11M055787
  • GC11M055994
  • GC11M056147
  • GC11M059669
  • GC11M050776
  • GC11M051571
  • GC11M052233
  • GC11M052893
  • GC11M053561
  • GC11M054227
  • GC11M054893
  • GC11M055590
  • GC11M061100
  • GC11M063582

Summaries for CHRM4 Gene

Entrez Gene Summary for CHRM4 Gene

  • The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHRM4 Gene

CHRM4 (Cholinergic Receptor Muscarinic 4) is a Protein Coding gene. Diseases associated with CHRM4 include Ureterolithiasis and Arthrogryposis, Distal, Type 1A. Among its related pathways are Monoamine GPCRs and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled acetylcholine receptor activity. An important paralog of this gene is CHRM2.

UniProtKB/Swiss-Prot Summary for CHRM4 Gene

  • The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.

Tocris Summary for CHRM4 Gene

  • Muscarinic receptors are widely distributed throughout the body and control distinct functions according to location and subtype (M1 - M5).They are predominantly expressed in the parasympathetic nervous system where they exert both inhibitory and excitatory effects.

Gene Wiki entry for CHRM4 Gene

Additional gene information for CHRM4 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CHRM4 Gene

Genomics for CHRM4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CHRM4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J046391 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 250.7 -0.1 -125 3 EZH2 SP1 MYC ZNF600 ZNF592 KLF9 CEBPA ZIC2 ZBTB10 MXD4 CHRM4 HSALNG0083992 AMBRA1 ATG13 ACP2 HSALNG0083993
GH11J046344 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12 +41.9 41870 10.4 SP1 ZNF654 MYC ZNF600 ZNF592 POLR2A ZIC2 ZBTB10 YY1 NONO DGKZ C11orf49 MDK CHRM4 LINC02489 CREB3L1 AMBRA1 PACSIN3 ATG13 ZNF408
GH11J046314 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 10.5 +74.4 74380 5.4 ZNF654 NCOR1 MYC IKZF1 ZNF592 NFIC CTCF REST TRIM22 BHLHE40 HSALNG0083982 LINC02489 CREB3L1 MDK CHRM4 PACSIN3 ATG13 C11orf49 LRP4 HSALNG0083981
GH11J046517 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.3 -131.2 -131224 15.2 BCLAF1 JUND CEBPA YY1 CTCF CEBPB REST DEK TRIM22 SIX4 ATG13 ZNF408 ENSG00000270060 AMBRA1 MDK DGKZ CHRM4 DDB2 HARBI1 C11orf49
GH11J046537 Enhancer 1 Ensembl ENCODE 12.1 -145.9 -145925 1.4 BCLAF1 IKZF1 ZNF654 CEBPA ZNF10 ZIC2 CTCF CEBPB REST DEK CHRM4 AMBRA1 MDK DGKZ ATG13 HARBI1 ENSG00000271350 lnc-HARBI1-1 HSALNG0083995
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CHRM4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CHRM4

Top Transcription factor binding sites by QIAGEN in the CHRM4 gene promoter:
  • NF-1
  • NF-1/L
  • STAT3

Genomic Locations for CHRM4 Gene

Latest Assembly
chr11:46,383,789-46,391,776
(GRCh38/hg38)
Size:
7,988 bases
Orientation:
Minus strand

Previous Assembly
chr11:46,405,339-46,413,326
(GRCh37/hg19 by Entrez Gene)
Size:
7,988 bases
Orientation:
Minus strand

chr11:46,406,640-46,408,107
(GRCh37/hg19 by Ensembl)
Size:
1,468 bases
Orientation:
Minus strand

Genomic View for CHRM4 Gene

Genes around CHRM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHRM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHRM4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CHRM4 Gene

Proteins for CHRM4 Gene

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  • Protein details for CHRM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08173-ACM4_HUMAN
    Recommended name:
    Muscarinic acetylcholine receptor M4
    Protein Accession:
    P08173
    Secondary Accessions:
    • B2RPP4
    • Q0VD60
    • Q4VBK7

    Protein attributes for CHRM4 Gene

    Size:
    479 amino acids
    Molecular mass:
    53049 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CHRM4 Gene

neXtProt entry for CHRM4 Gene

Protein Expression for CHRM4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CHRM4 Gene

  • Glycosylation at Asn8 and Asn13
  • Modification sites at PhosphoSitePlus

Other Protein References for CHRM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHRM4 Gene

Domains & Families for CHRM4 Gene

Gene Families for CHRM4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for CHRM4 Gene

InterPro:
Blocks:
  • Muscarinic acetylcholine receptor signature
  • Muscarinic M4 receptor signature

Suggested Antigen Peptide Sequences for CHRM4 Gene

GenScript: Design optimal peptide antigens:
  • Muscarinic acetylcholine receptor M4 (ACM4_HUMAN)
  • M4 muscarinic cholinergic receptor (Q96RG8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08173

UniProtKB/Swiss-Prot:

ACM4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily.
genes like me logo Genes that share domains with CHRM4: view

Function for CHRM4 Gene

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  6. Cell Lines for research

Molecular function for CHRM4 Gene

UniProtKB/Swiss-Prot Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
GENATLAS Biochemistry:
cholinergic receptor,muscarinic 4,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for CHRM4 Gene

Gene Ontology (GO) - Molecular Function for CHRM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004993 G protein-coupled serotonin receptor activity IBA 21873635
GO:0005515 protein binding IPI 15518545
GO:0016907 G protein-coupled acetylcholine receptor activity TAS,IBA 21873635
GO:0030594 neurotransmitter receptor activity IBA 21873635
genes like me logo Genes that share ontologies with CHRM4: view
genes like me logo Genes that share phenotypes with CHRM4: view

Animal Models for CHRM4 Gene

MGI Knock Outs for CHRM4:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHRM4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CHRM4 Gene

Localization for CHRM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRM4 Gene

Cell membrane. Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHRM4 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CHRM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CHRM4: view

Pathways & Interactions for CHRM4 Gene

genes like me logo Genes that share pathways with CHRM4: view

Pathways by source for CHRM4 Gene

1 GeneGo (Thomson Reuters) pathway for CHRM4 Gene
  • Development ACM2 and ACM4 activation of ERK

SIGNOR curated interactions for CHRM4 Gene

Activates:

Gene Ontology (GO) - Biological Process for CHRM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9603968
GO:0007166 cell surface receptor signaling pathway TAS 2739737
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA 21873635
GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IEA,IBA 21873635
genes like me logo Genes that share ontologies with CHRM4: view

Drugs & Compounds for CHRM4 Gene

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(161) Drugs for CHRM4 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atropine Approved, Vet_approved Pharma Antagonist, Target MAChRs antagonist 227
Darifenacin Approved, Investigational Pharma Antagonist, Target 26
Acetylcholine Approved, Investigational Pharma Agonist, Full agonist, Target 937
Tropicamide Approved, Investigational Pharma Target, antagonist Antimuscarinic drug, Selective M4 muscarinic antagonist 37
Doxepin Approved, Investigational Pharma Target, antagonist, inhibitor 18

(7) Additional Compounds for CHRM4 Gene - From: HMDB, IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(-)aceclidine
Agonist, Partial agonist
(+)aceclidine
Agonist, Full agonist
HHSiD
Antagonist
N-Dealkylated tolterodine
Promazine 5-sulfoxide
  • Promazine 5-sulphoxide

(4) Tocris Compounds for CHRM4 Gene

Compound Action Cas Number
PD 102807 Selective M4 antagonist 23062-91-1
Tropicamide Selective M4 muscarinic antagonist 1508-75-4
VU 10010 Selective allosteric potentiator of M4 receptors 633283-39-3
VU 152100 Positive allosteric modulator of M4 receptors 409351-28-6

(42) ApexBio Compounds for CHRM4 Gene

Compound Action Cas Number
(+)-Muscarine iodide 24570-49-8
(S)-(+)-Dimethindene maleate 136152-65-3
4-DAMP 1952-15-4
5-Methylfurmethiodide 1197-60-0
Aclidinium Bromide LAMAs antagonist 320345-99-1
AF-DX 116 102394-31-0
AF-DX 384 118290-26-9
Arecaidine but-2-ynyl ester tosylate 119630-77-2
Arecaidine propargyl ester tosylate 147202-94-6
Arecoline hydrobromide Muscarinic receptor agonist 300-08-3
Biperiden HCl Anticholinergic drug 1235-82-1
Cevimeline Muscarinic receptor agonist 107233-08-9
Darifenacin HBr 133099-07-7
DAU 5884 hydrochloride 131780-48-8
Dicyclomine HCl 67-92-5
Diphenylpyraline HCl 132-18-3
Fesoterodine Fumarate 286930-03-8
J 104129 fumarate 257603-40-0
McN-A 343 55-45-8
Mepenzolate Bromide mAChR antagonist 76-90-4
Milameline hydrochloride 139886-04-7
Nitrocaramiphen hydrochloride 98636-73-8
Oxotremorine M 3854-04-4
Oxotremorine sesquifumarate 17360-35-9
PD 102807 23062-91-1
Pirenzepine dihydrochloride 29868-97-1
Pridinol Methanesulfonate 6856-31-1
PTAC oxalate 201939-40-4
Scopolamine butylbromide 149-64-4
Scopolamine hydrobromide 114-49-8
Solifenacin hydrochloride 180468-39-7
Solifenacin succinate Muscarinic receptor antagonist 242478-38-2
Telenzepine dihydrochloride 147416-96-4
Tolterodine tartrate 124937-52-6
VU 0238429 1160247-92-6
VU 0255035 1135243-19-4
VU 0357017 hydrochloride 1135242-13-5
VU 0365114 1208222-39-2
VU 10010 633283-39-3
VU0152100 M4 receptor allosteric modulators 409351-28-6
W-84 dibromide 21093-51-6
Zamifenacin fumarate 127308-98-9
genes like me logo Genes that share compounds with CHRM4: view

Drug products for research

Transcripts for CHRM4 Gene

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mRNA/cDNA for CHRM4 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHRM4

Alternative Splicing Database (ASD) splice patterns (SP) for CHRM4 Gene

No ASD Table

Relevant External Links for CHRM4 Gene

GeneLoc Exon Structure for
CHRM4

Expression for CHRM4 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHRM4 Gene

mRNA expression in normal human tissues for CHRM4 Gene
mRNA expression by GTEx for CHRM4 GenemRNA expression by BioGPS for CHRM4 Gene

mRNA differential expression in normal tissues according to GTEx for CHRM4 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x8.6), Brain - Nucleus accumbens (basal ganglia) (x8.0), Brain - Caudate (basal ganglia) (x7.5), and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for CHRM4 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CHRM4 Gene



Protein tissue co-expression partners for CHRM4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CHRM4

SOURCE GeneReport for Unigene cluster for CHRM4 Gene:

Hs.248100

Evidence on tissue expression from TISSUES for CHRM4 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with CHRM4: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHRM4 Gene

Orthologs for CHRM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRM4 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
 Mammalia CHRM4 30
  • 95 (a)
 OneToOne
Chimpanzee
(Pan troglodytes)
 Mammalia CHRM4 30
  • 93 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CHRM4 29 30
  • 92.47 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Chrm4 29 16 30
  • 89.61 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Chrm4 29
  • 89.4 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 30
  • 87 (a)
 OneToMany
-- 30
  • 72 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves CHRM4 29 30
  • 75.43 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia CHRM4 30
  • 74 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia chrm4 29
  • 71.61 (n)
Zebrafish
(Danio rerio)
 Actinopterygii chrm4a 29 30
  • 71.21 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta CG7918 31
  • 38 (a)
mAcR-60C 30 31
  • 24 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea gar-3 30
  • 27 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 34 (a)
 OneToMany
Species where no ortholog for CHRM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CHRM4 Gene

ENSEMBL:
Gene Tree for CHRM4 (if available)
TreeFam:
Gene Tree for CHRM4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CHRM4: view image
Alliance of Genome Resources:
Additional Orthologs for CHRM4

Paralogs for CHRM4 Gene

Paralogs for CHRM4 Gene

(9) SIMAP similar genes for CHRM4 Gene using alignment to 2 proteins:

  • ACM4_HUMAN
  • Q96RG8_HUMAN
genes like me logo Genes that share paralogs with CHRM4: view

Variants for CHRM4 Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CHRM4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CHRM4 Gene

Variant ID Type Subtype PubMed ID
esv3626183 CNV gain 21293372
esv3626185 CNV loss 21293372
nsv309 CNV deletion 18451855
nsv554201 CNV loss 21841781
nsv554202 CNV loss 21841781
nsv825867 CNV gain 20364138
nsv951610 CNV deletion 24416366

Variation tolerance for CHRM4 Gene

Residual Variation Intolerance Score: 19.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHRM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHRM4
Leiden Open Variation Database (LOVD)
CHRM4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CHRM4 Gene

Disorders for CHRM4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CHRM4 Gene - From: COP

Disorder Aliases PubMed IDs
ureterolithiasis
  • calculus of ureter
arthrogryposis, distal, type 1a
  • da1a
cone-rod dystrophy 2
  • cord2
disease of mental health
  • mental health
- elite association - COSMIC cancer census association via MalaCards
Search CHRM4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CHRM4

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CHRM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHRM4 Gene

Publications for CHRM4 Gene

  1. Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B … WHO/ISBRA Study on State and Trait Markers of Alcoholism (BMC biology 2009) 3 40
  2. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need AC … Goldstein DB (European journal of human genetics : EJHG 2009) 3 40
  3. Muscarinic M4 receptor recycling requires a motif in the third intracellular loop. (PMID: 18337477) Hashimoto Y … Haga T (The Journal of pharmacology and experimental therapeutics 2008) 3 22
  4. No evidence for association between 19 cholinergic genes and bipolar disorder. (PMID: 17373692) Shi J … Liu C (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 40
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

ExternalLinks

View latest publications for CHRM4 gene in Mastermind

Products for CHRM4 Gene

  • Addgene plasmids for CHRM4

Sources for CHRM4 Gene