Aliases for CHRM4 Gene
Aliases for CHRM4 Gene
External Ids for CHRM4 Gene
- HGNC: 1953
- Entrez Gene: 1132
- Ensembl: ENSG00000180720
- OMIM: 118495
- UniProtKB: P08173
Previous GeneCards Identifiers for CHRM4 Gene
- GC11M048191
- GC11M047097
- GC11M046438
- GC11M046370
- GC11M046363
- GC11M046113
- GC11M046406
- GC11M047073
- GC11M047919
- GC11M050776
- GC11M051571
- GC11M052233
- GC11M052893
- GC11M053561
Summaries for CHRM4 Gene
-
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]
GeneCards Summary for CHRM4 Gene
CHRM4 (Cholinergic Receptor Muscarinic 4) is a Protein Coding gene. Among its related pathways are Circadian entrainment and Monoamine GPCRs. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled acetylcholine receptor activity. An important paralog of this gene is CHRM2.
UniProtKB/Swiss-Prot for CHRM4 Gene
-
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
-
Muscarinic receptors are widely distributed throughout the body and control distinct functions according to location and subtype (M1 - M5).They are predominantly expressed in the parasympathetic nervous system where they exert both inhibitory and excitatory effects.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRM4 Gene
Genomics for CHRM4 Gene
GeneHancer (GH) Regulatory Elements for CHRM4 Gene
Promoters and enhancers for CHRM4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CHRM4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CHRM4 gene promoter:
Regulatory Element Products
Genomic Locations for CHRM4 Gene
Genomic Locations for CHRM4 Gene
- chr11:46,384,792-46,386,608
- (GRCh38/hg38)
- Size:
- 1,817 bases
- Orientation:
- Minus strand
- chr11:46,406,640-46,408,107
- (GRCh37/hg19)
Genomic View for CHRM4 Gene
Genes around CHRM4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by Ensembl
- 11p11.2 by Entrez Gene
- 11p11.2 by HGNC
CHRM4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CHRM4 Gene
Proteins for CHRM4 Gene
-
Protein details for CHRM4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08173-ACM4_HUMAN
- Recommended name:
- Muscarinic acetylcholine receptor M4
- Protein Accession:
- P08173
- B2RPP4
- Q0VD60
- Q4VBK7
Protein attributes for CHRM4 Gene
- Size:
- 479 amino acids
- Molecular mass:
- 53049 Da
- Quaternary structure:
- No Data Available
Protein Expression for CHRM4 Gene
Post-translational modifications for CHRM4 Gene
- Glycosylation at Asn8 and posLast=1313
Other Protein References for CHRM4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CHRM4
-
Abcam antibodies for CHRM4
- Invitrogen Antibodies for CHRM4
- antibodies-online: Search results for 42 available CHRM4 Antibodies ranked by validation data
- Compare Top CHRM4 Antibodies
-
Recommended
- 12 IF (p) Antibodies (anti-rat)
- 7 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IF/ICC Antibody (anti-rat)
- 14 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 12 IF (p) Antibodies (anti-mouse)
- 8 WB Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- Search GeneTex for Antibodies for CHRM4
Protein Products
-
OriGene Purified Proteins for CHRM4
- Search Origene for MassSpec and Protein Over-expression Lysates for CHRM4
- Origene Custom Protein Services for CHRM4
- Search GeneTex for Proteins for CHRM4
Assay Products
No data available for DME Specific Peptides for CHRM4 Gene
Domains & Families for CHRM4 Gene
Gene Families for CHRM4 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for CHRM4 Gene
Suggested Antigen Peptide Sequences for CHRM4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P08173UniProtKB/Swiss-Prot:
ACM4_HUMAN :- Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily.
- Family:
-
- Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily.
Function for CHRM4 Gene
Molecular function for CHRM4 Gene
- GENATLAS Biochemistry:
- cholinergic receptor,muscarinic 4,G protein coupled receptor superfamily
- UniProtKB/Swiss-Prot Function:
- The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
Phenotypes From GWAS Catalog for CHRM4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IEA | -- |
| GO:0016907 | G-protein coupled acetylcholine receptor activity | IBA | -- |
Phenotypes for CHRM4 Gene
- MGI mutant phenotypes for CHRM4:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for CHRM4:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Increased HPV18 LCR reporter activity
- Increased HPV16-GFP infection
- Decreased shRNA abundance (Z-score < -2)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHRM4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CHRM4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRM4 gene
- Search ViGene Biosciences for CHRM4
CRISPR Products
-
OriGene CRISPR knockouts for CHRM4
- genomics-online: gRNA clones - Search results for available CHRM4 gene related products
- Applied Biological Materials CRISPR for CHRM4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHRM4
- GenScript: Design CRISPR guide RNA sequences for CHRM4
miRNA Products
- Search ViGene Biosciences for CHRM4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CHRM4
- Browse OriGene Inhibitory RNA Products For CHRM4
- genomics-online: shRNA clones - Search results for available CHRM4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRM4 gene
Clone Products
- Sino Biological Human cDNA Clone for CHRM4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CHRM4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHRM4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CHRM4
- genomics-online: cdna clones - Search results for available CHRM4 gene related products
- orf clones - Search results for available CHRM4 gene related products
- Applied Biological Materials Clones for CHRM4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CHRM4
Cell Line Products
-
Horizon Cell Lines for CHRM4
-
ViGene Biosciences adenoviral particle packaged cDNA for CHRM4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CHRM4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRM4 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CHRM4 Gene
Localization for CHRM4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CHRM4 Gene
- Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endosome | 1 |
- Golgi apparatus (1)
- Nucleus (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS,IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030054 | cell junction | IEA | -- |
Pathways & Interactions for CHRM4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Monoamine GPCRs |
.75
|
|
| 3 | Signaling by GPCR | ||
| 4 | Regulation of actin cytoskeleton | ||
| 5 | Circadian entrainment | ||
Pathways by source for CHRM4 Gene
4 BioSystems pathways for CHRM4 Gene
8 Reactome pathways for CHRM4 Gene
3 KEGG pathways for CHRM4 Gene
1 GeneGo (Thomson Reuters) pathway for CHRM4 Gene
Interacting Proteins for CHRM4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | TAS | 9603968 |
| GO:0007166 | cell surface receptor signaling pathway | TAS | 2739737 |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
| GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway | IEA,IBA | -- |
| GO:0007207 | phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway | IBA | -- |
No data available for SIGNOR curated interactions for CHRM4 Gene
Drugs & Compounds for CHRM4 Gene
(156) Drugs for CHRM4 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Tropicamide | Approved, Investigational | Pharma | Target, antagonist | Antimuscarinic drug, Selective M4 muscarinic antagonist | 25 | |
| Atropine | Approved, Vet_approved | Pharma | Antagonist, Target, antagonist | MAChRs antagonist | 153 | |
| Darifenacin | Approved, Investigational | Pharma | Antagonist, Target, antagonist | M3 receptor antagonist and antimuscarinic agents | 22 | |
| Acetylcholine | Approved | Pharma | Full agonist, Agonist, Target | 863 | ||
| Doxepin | Approved, Investigational | Pharma | Antagonist, Target, antagonist, inhibitor | 14 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (-)aceclidine |
|
Partial agonist, Agonist |
|
|||
| (+)aceclidine |
|
Full agonist, Agonist |
|
|||
| Gouml 7874 |
|
Negative, Allosteric regulator |
|
|||
| HHSiD |
|
Antagonist |
|
|||
| N-Dealkylated tolterodine |
|
|
(4) Tocris Compounds for CHRM4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| PD 102807 | Selective M4 antagonist | 23062-91-1 |
| Tropicamide | Selective M4 muscarinic antagonist | 1508-75-4 |
| VU 10010 | Selective allosteric potentiator of M4 receptors | 633283-39-3 |
| VU 152100 | Positive allosteric modulator of M4 receptors | 409351-28-6 |
(44) ApexBio Compounds for CHRM4 Gene
Transcripts for CHRM4 Gene
mRNA/cDNA for CHRM4 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (10) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CHRM4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CHRM4
- genomics-online: gRNA clones - Search results for available CHRM4 gene related products
- Applied Biological Materials CRISPR for CHRM4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHRM4
- GenScript: Design CRISPR guide RNA sequences for CHRM4
miRNA Products
- Search ViGene Biosciences for CHRM4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CHRM4
- Browse OriGene Inhibitory RNA Products For CHRM4
- genomics-online: shRNA clones - Search results for available CHRM4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRM4 gene
Clone Products
- Sino Biological Human cDNA Clone for CHRM4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CHRM4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHRM4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CHRM4
- genomics-online: cdna clones - Search results for available CHRM4 gene related products
- orf clones - Search results for available CHRM4 gene related products
- Applied Biological Materials Clones for CHRM4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CHRM4
Expression for CHRM4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
mRNA differential expression in normal tissues according to GTEx for CHRM4 Gene
This gene is overexpressed in Brain - Putamen (basal ganglia) (x8.6), Brain - Nucleus accumbens (basal ganglia) (x8.0), Brain - Caudate (basal ganglia) (x7.5), and Spleen (x4.2).
This gene is overexpressed in Platelet (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHRM4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CHRM4 Gene:
CHRM4SOURCE GeneReport for Unigene cluster for CHRM4 Gene:
Hs.248100Evidence on tissue expression from TISSUES for CHRM4 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for CHRM4
-
OriGene qPCR primer pairs and template standards for CHRM4
- genomics-online: primer clones - Search results for available CHRM4 gene related products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHRM4 Gene
Orthologs for CHRM4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | CHRM4 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | CHRM4 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CHRM4 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Chrm4 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Chrm4 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | CHRM4 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CHRM4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | chrm4 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | chrm4a 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | mAcR-60C 35 34 |
|
||
| CG7918 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | gar-3 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for CHRM4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CHRM4 Gene
Variants for CHRM4 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000159355 | -- | 46,386,758(-) | C/G | upstream_transcript_variant | |
| rs1000209568 | -- | 46,386,312(-) | G/A | coding_sequence_variant, synonymous_variant | |
| rs1000320104 | -- | 46,387,010(-) | G/A | upstream_transcript_variant | |
| rs1001164681 | -- | 46,388,087(-) | C/T | upstream_transcript_variant | |
| rs1001216819 | -- | 46,387,927(-) | G/T | upstream_transcript_variant |
Residual Variation Intolerance Score:
19.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.49;
10.59% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CHRM4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CHRM4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRM4 Gene
Disorders for CHRM4 Gene
Additional Disease Information for CHRM4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CHRM4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHRM4 Gene
Publications for CHRM4 Gene
- Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B … WHO/ISBRA Study on State and Trait Markers of Alcoholism (BMC biology 2009) 3 44 58
- Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need AC … Goldstein DB (European journal of human genetics : EJHG 2009) 3 44 58
- Muscarinic M4 receptor recycling requires a motif in the third intracellular loop. (PMID: 18337477) Hashimoto Y … Haga T (The Journal of pharmacology and experimental therapeutics 2008) 3 22 58
- No evidence for association between 19 cholinergic genes and bipolar disorder. (PMID: 17373692) Shi J … Liu C (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 44 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for CHRM4 Gene
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CHRM4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CHRM4
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHRM4
- VectorBuilder custom plasmid, inducible vectors for CHRM4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHRM4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CHRM4
- antibodies-online: Search results for 42 available CHRM4 Antibodies ranked by validation data
- Compare Top CHRM4 Antibodies
- Recommended
- 12 IF (p) Antibodies (anti-rat)
- 7 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IF/ICC Antibody (anti-rat)
- 14 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 12 IF (p) Antibodies (anti-mouse)
- 8 WB Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- antibodies-online: Search results for 2 available CHRM4 Elisa Kits ranked by validation data
- Compare Top CHRM4 Elisa Kits
- Recommended
- antibodies-online: Search results for 6 available CHRM4 Proteins ranked by validation data
- Compare Top CHRM4 Proteins
- Search GeneTex for Antibodies for CHRM4
- Search GeneTex for Proteins for CHRM4
- ViGene Biosciences adenoviral particle packaged cDNA for CHRM4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CHRM4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CHRM4 gene
- Search ViGene Biosciences for CHRM4
- Horizon Cell Lines for CHRM4
- genomics-online: cdna clones - Search results for available CHRM4 gene related products
- orf clones - Search results for available CHRM4 gene related products
- genomics-online: gRNA clones - Search results for available CHRM4 gene related products
- genomics-online: primer clones - Search results for available CHRM4 gene related products
- genomics-online: shRNA clones - Search results for available CHRM4 gene related products
Sources for CHRM4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew