Aliases for CHRM1 Gene
External Ids for CHRM1 Gene
Previous GeneCards Identifiers for CHRM1 Gene
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]
GeneCards Summary for CHRM1 Gene
CHRM1 (Cholinergic Receptor Muscarinic 1) is a Protein Coding gene. Diseases associated with CHRM1 include Heart Block, Congenital and Pelizaeus-Merzbacher Disease. Among its related pathways are Monoamine GPCRs and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and phosphatidylinositol phospholipase C activity. An important paralog of this gene is CHRM3.
UniProtKB/Swiss-Prot Summary for CHRM1 Gene
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Muscarinic receptors are widely distributed throughout the body and control distinct functions according to location and subtype (M1 - M5).They are predominantly expressed in the parasympathetic nervous system where they exert both inhibitory and excitatory effects.